Western diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy [0.03%]
西方饮食可诱发Mybpc3位点杂合突变小鼠心脏功能障碍：肥厚性心肌病的双重打击模型
Edgar E Nollet,Sila Algül,Max Goebel et al.
Edgar E Nollet et al.
Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger car...
Starting off strong: Rigor and reproducibility in the early career [0.03%]
严守科研规范，确保研究可重复性——致初入职场的科学家们
Ronald J Vagnozzi
Ronald J Vagnozzi
The effect of moderate intensity aerobic exercise on cardiovascular function, cardiorespiratory fitness and estrogen receptor alpha gene in overweight/obese postmenopausal women: A randomized controlled trial [0.03%]
中等强度有氧运动对超重和肥胖绝经后女性心血管功能、心肺健康及雌激素受体α基因的影响：一项随机对照试验
Abbas Malandish,Mohammad Rahmati-Yamchi
Abbas Malandish
Objective: The purpose of this study was to examine the effect of 12 weeks of moderate intensity aerobic exercise on echocardiographic and cardiorespiratory fitness (CRF) parameters, lymphocyte estrogen receptor alpha (ER...
Dominic P Del Re,Qinghang Liu
Dominic P Del Re
Jolanda van der Velden
Jolanda van der Velden
Cardiac-specific ITCH overexpression ameliorates septic cardiomyopathy via inhibition of the NF-κB signaling pathway [0.03%]
心脏特异性过表达ITCH通过抑制NF-κB信号通路改善脓毒症心肌病
Yuji Saito,Yoichiro Otaki,Tetsu Watanabe et al.
Yuji Saito et al.
Background: Septic cardiomyopathy is a common complication of septic shock and organ dysfunction. ITCH is a HECT (homologous to the E6-AP carboxyl-terminus)-type ubiquitin E3 ligase that plays a critical role in inflammat...
A gradient of force generation at rest differentiates cardiomyopathy outcomes with variants of actin located at the same residue [0.03%]
休息时产生力的梯度分化了位于同一残基的肌动蛋白变异体的心肌病结果
Michael R Jones,Chau Tran,Jaskerat Singh et al.
Michael R Jones et al.
The calcium sensitivity hypothesis helps explain the development of different forms of cardiomyopathy: increased sensitivity to calcium in cardiac sarcomeres leads to hypertrophic cardiomyopathy (HCM) and decreased sensitivity results in di...
Transcriptomics reveal stretched human pluripotent stem cell-derived cardiomyocytes as an advantageous hypertrophy model [0.03%]
转录组揭示拉伸的人类多能干细胞源心肌细胞作为重构的有利模型
Lotta Pohjolainen,Heikki Ruskoaho,Virpi Talman
Lotta Pohjolainen
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocyt...
Targeting miR-199a reduces fibrosis in hypertrophic cardiomyopathy [0.03%]
靶向miR-199a可降低肥厚型心肌病患者的纤维化水平
Stanislovas S Jankauskas,Fahimeh Varzideh,Urna Kansakar et al.
Stanislovas S Jankauskas et al.