Sacubitril/valsartan reduces proteasome activation and cardiomyocyte area in an experimental mouse model of hypertrophy [0.03%]
萨库布维林缬沙坦通过减少激活的蛋白酶体和心肌细胞面积来抑制小鼠实验性肥大模型中的心室重构
Moritz Meyer-Jens,Kristin Wenzel,Karina Grube et al.
Moritz Meyer-Jens et al.
Sacubitril/valsartan (Sac/Val) belongs to the group of angiotensin receptor-neprilysin inhibitors and has been used for the treatment of heart failure (HF) for several years. The mechanisms that mediate the beneficial effects of Sac/Val are...
Rebekah L Gundry,Davor Pavlovic
Rebekah L Gundry
An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy [0.03%]
一项优化的血浆型磷脂调节型膳食补充剂可为雄性小鼠扩张型心肌病模型提供更多的保护作用，而对雌性小鼠则不然
Teleah G Belkin,Emma I Masterman,Gunes S Yildiz et al.
Teleah G Belkin et al.
We previously reported that plasmalogens, a class of phospholipids, were decreased in a setting of dilated cardiomyopathy (DCM). Plasmalogen levels can be modulated via a dietary supplement called alkylglycerols (AG) which has demonstrated ...
Circulating autophagy regulator Rubicon is linked to increased myocardial infarction risk [0.03%]
循环自噬调节因子Rubicon与增加的心肌梗死风险相关
Marie-Hélène Grazide,Jean-Bernard Ruidavets,Wim Martinet et al.
Marie-Hélène Grazide et al.
Background: The identification of new biomarkers that improve existing cardiovascular risk prediction models for acute coronary syndrome is essential for accurately identifying high-risk patients and refining treatment st...
Genetic deletion of 12/15 lipoxygenase delays vascular remodeling and limits cardiorenal dysfunction after pressure overload [0.03%]
压力超负荷后遗传删除12 / 15-脂氧合酶延迟血管重塑并限制心肾功能障碍
Dae Hyun Lee,Vasundhara Kain,Da-Zhi Wang et al.
Dae Hyun Lee et al.
The lipid metabolizing enzyme 12/15 lipoxygenase (12/15LOX) induces proinflammatory responses that may increase cardiovascular and renal complications after cardiac insult. To define the role of 12/15LOX, 8-12-week-old male C57BL/6J wild-ty...
The mechano-electric feedback mediates the dual effect of stretch in mouse sinoatrial tissue [0.03%]
机械电反馈介导了小鼠心房窦组织牵张的双重作用
Limor Arbel Ganon,Rami Eid,Matan Hamra et al.
Limor Arbel Ganon et al.
The sinoatrial node (SAN) is the primary heart pacemaker. The automaticity of SAN pacemaker cells is regulated by an integrated coupled-clock system. The beat interval (BI) of SAN, and its primary initiation location (inferior vs. superior)...
Sex-specific effects of in vitro culture and embryo transfer on cardiac growth in sheep offspring [0.03%]
体外培养和胚胎移植对绵羊后代心脏生长的性别特异性影响
Monalisa Padhee,Mitchell C Lock,I Caroline McMillen et al.
Monalisa Padhee et al.
Embryo culture with and without human serum supplementation, previously common practice in assisted reproductive technologies (ARTs), have been associated with increased heart weight in early and late gestation in the sheep fetus. The prese...
Omecamtiv mecarbil in precision-cut living heart failure slices: A story of a double-edged sword [0.03%]
奥马西韦麦克达比尔在精密切割的活体心力衰竭切片中的研究：一把双刃剑的故事
Jorik H Amesz,Sanne J J Langmuur,Mark F A Bierhuizen et al.
Jorik H Amesz et al.
Heart failure (HF) is a rapidly growing pandemic while medical treatment options remain limited. Omecamtiv mecarbil (OM) is a novel HF drug that directly targets the myosin heads of the cardiac muscle. This study used living myocardial slic...
Unveiling the neural remodelling landscape in heart failure: A new frontier in cardiac arrhythmogenesis research [0.03%]
揭开心力衰竭中神经重塑的景观：心脏电重构研究的新前沿
Alexander Grassam-Rowe,Ming Lei
Alexander Grassam-Rowe
Circulating levels of cadherins are associated with atherosclerosis and cardiovascular outcomes [0.03%]
血浆闭合蛋白与动脉粥样硬化和心血管结局的关系
Gaetano Santulli,Fahimeh Varzideh,Yifei Qin et al.
Gaetano Santulli et al.