Jolanda van der Velden
Jolanda van der Velden
Cardiac-specific ITCH overexpression ameliorates septic cardiomyopathy via inhibition of the NF-κB signaling pathway [0.03%]
心脏特异性过表达ITCH通过抑制NF-κB信号通路改善脓毒症心肌病
Yuji Saito,Yoichiro Otaki,Tetsu Watanabe et al.
Yuji Saito et al.
Background: Septic cardiomyopathy is a common complication of septic shock and organ dysfunction. ITCH is a HECT (homologous to the E6-AP carboxyl-terminus)-type ubiquitin E3 ligase that plays a critical role in inflammat...
A gradient of force generation at rest differentiates cardiomyopathy outcomes with variants of actin located at the same residue [0.03%]
休息时产生力的梯度分化了位于同一残基的肌动蛋白变异体的心肌病结果
Michael R Jones,Chau Tran,Jaskerat Singh et al.
Michael R Jones et al.
The calcium sensitivity hypothesis helps explain the development of different forms of cardiomyopathy: increased sensitivity to calcium in cardiac sarcomeres leads to hypertrophic cardiomyopathy (HCM) and decreased sensitivity results in di...
Transcriptomics reveal stretched human pluripotent stem cell-derived cardiomyocytes as an advantageous hypertrophy model [0.03%]
转录组揭示拉伸的人类多能干细胞源心肌细胞作为重构的有利模型
Lotta Pohjolainen,Heikki Ruskoaho,Virpi Talman
Lotta Pohjolainen
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocyt...
Targeting miR-199a reduces fibrosis in hypertrophic cardiomyopathy [0.03%]
靶向miR-199a可降低肥厚型心肌病患者的纤维化水平
Stanislovas S Jankauskas,Fahimeh Varzideh,Urna Kansakar et al.
Stanislovas S Jankauskas et al.
Pooled microarray expression analysis of failing left ventricles reveals extensive cellular-level dysregulation independent of age and sex [0.03%]
pooling分析失败的左心室微阵列表达发现广泛的细胞水平调节独立于年龄和性别
Youdinghuan Chen
Youdinghuan Chen
Existing cardiovascular studies tend to suffer from small sample sizes and unaddressed confounders. Re-profiling of 9 microarray datasets revealed significant global gene expression differences between 358 failing and 191 non-failing left v...
Quest for the ideal assessment of electrical ventricular dyssynchrony in cardiac resynchronization therapy [0.03%]
心室不同步电学评价在心脏再同步治疗中的求索之旅
Uyên Châu Nguyên,Kevin Vernooy,Frits W Prinzen
Uyên Châu Nguyên
This paper reviews the literature on assessing electrical dyssynchrony for patient selection in cardiac resynchronization therapy (CRT). The guideline-recommended electrocardiographic (ECG) criteria for CRT are QRS duration and morphology, ...
Sex, drugs and high fat diet: Characterizing HFpEF in female C57BL6/J mice [0.03%]
性、药物与高脂饮食：关于C57BL6/J雌鼠HFpEF的特征描述
Joshua Travers,Emma L Robinson
Joshua Travers
Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation [0.03%]
选择反复出现的具有最高概率成为房颤发病焦点和旋涡激活模式
Ben J M Hermans,Ozan Özgül,Michael Wolf et al.
Ben J M Hermans et al.
Introduction: Repetitive focal and rotational activation patterns are currently used as additional ablation targets for atrial fibrillation (AF). However, there is no evidence that all these detected targets are actual so...
A novel sequential endocardial mapping strategy for locating atrial fibrillation sources based on repetitive conduction patterns: An in-silico study [0.03%]
一种新的序贯心内膜mapping策略，用于基于重复传导模式的定位房颤来源：一项in-silico研究
Victor Gonçalves Marques,Ali Gharaviri,Ozan Özgül et al.
Victor Gonçalves Marques et al.
Background: In persistent atrial fibrillation (AF), localized extra-pulmonary vein sources may contribute to arrhythmia recurrences after pulmonary vein isolation. This in-silico study proposes a high-density sequential m...