MicroRNA miR-378-3p is a novel regulator of endothelial autophagy and function [0.03%]
microRNA miR-378-3p 是内皮自噬和功能的新调节因子
Shuhan Bu,Jameela J Joseph,Hien C Nguyen et al.
Shuhan Bu et al.
Autophagy is a highly conserved cellular process in which cytoplasmic materials are internalized into an autophagosome that later fuses with a lysosome for their degradation and recycling. MicroRNAs (miRNAs) are integral regulators in vario...
Multi-scale modeling will unravel connections between sarcomeric mutations and cardiomyopathies [0.03%]
多尺度模型将揭示肌小节突变与心肌病之间的联系
Stuart G Campbell,Jeffrey R Moore,Michael J Rynkiewicz et al.
Stuart G Campbell et al.
DEG (differentially expressed gene) or not DEG that is the question: Should we compare between datasets or not? [0.03%]
差异表达基因(DEG)还是不是DEG，这是一个问题：我们是否应该在数据集之间进行比较？
Ashutosh Tomar,Samaneh Ekhteraei-Tousi,H Llewelyn Roderick
Ashutosh Tomar
Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension [0.03%]
选择性5-羟色胺再摄取抑制剂帕罗西汀可改善实验性肺动脉高压右心室收缩功能
Mark T Waddingham,Hirotsugu Tsuchimochi,Takashi Sonobe et al.
Mark T Waddingham et al.
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent fa...
Endothelial identity not found - Beyond passage 38, commercial cardiac microvascular endothelial cells do not express CD31 and VE-cadherin [0.03%]
内皮细胞身份丢失：传代超过38代后商业来源的心脏微血管内皮细胞不再表达CD31和VE-钙粘蛋白
Sarah Hilderink,Jolanda van der Velden,Diederik W D Kuster
Sarah Hilderink
Few immortalized cardiac microvascular endothelial cell (CMEC) lines are available, particularly mouse lines. We purchased the CLU510 mCMEC line (Cedarlane), isolated by fluorescence-activated cell sorting for CD31 and VE-cadherin. The cell...
The cardiac blood transcriptome predicts de novo onset of atrial fibrillation in heart failure [0.03%]
心力衰竭患者心脏血液转录组预测房颤的新发发生
Guillaume Lamirault,Imen Fellah-Hebia,Catherine Chevalier et al.
Guillaume Lamirault et al.
Heart failure (HF) increases the risk of developing atrial fibrillation (AF), leading to increased morbidity and mortality. Therefore, better prediction of this risk may improve treatment strategies. Although several predictors based on cli...
Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges [0.03%]
转录组学在动脉粥样硬化研究中的应用：揭示斑块表型和克服方法学挑战
Miron Sopić,Kanita Karaduzovic-Hadziabdic,Dimitris Kardassis et al.
Miron Sopić et al.
Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a power...
Genetics-diet crossroads: Unveiling new insights into hypertrophic cardiomyopathy [0.03%]
遗传与饮食的交汇点：肥厚型心肌病的新见解
Steffen P Häseli,Gabriele G Schiattarella
Steffen P Häseli
Endothelin-based markers for endothelial dysfunction in chemotherapy-induced cardiotoxicity [0.03%]
化疗所致心毒性内皮功能障碍的内皮素标志物
Gabrielle Boutin,Jale Yuzugulen,Md Zahidul Islam Pranjol
Gabrielle Boutin
Current cardiac biomarkers, troponins and brain natriuretic peptide, are primarily used to assist in the diagnosis or exclusion of myocardial damage and congestive heart failure, respectively. The use of these biomarkers in chemotherapy-ind...