Qifang Wu,Christine Gille,Florian Maderspacher et al.
Qifang Wu et al.
Thrombosis and thromboembolism are serious clinical complications of cardiovascular diseases and are among the leading causes of mortality worldwide. Dysregulation of the renin-angiotensin system is associated with an increased incidence of...
In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol [0.03%]
深入蛋白质谱分析揭示了7-酮胆固醇对LPS反应的增强作用
Iain R Phair,Magdalena Sovakova,Noor Alqurashi et al.
Iain R Phair et al.
In patients with stable coronary artery disease, plasma levels of 7-ketocholesterol (7-KC), found at high levels in atherosclerotic lesions, predict risk of incident heart failure dose dependently, potentially contributing to disease aetiol...
Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock [0.03%]
循环miR-20b-5p水平与心源性休克患者生存率的关系
Tuomas Mäntylä,Chunguang Wang,Mikko Hänninen et al.
Tuomas Mäntylä et al.
Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adverse outcomes. This study aimed to investigate the prognostic potential of microRNAs (miRN...
Deep plasma and tissue proteome profiling of knockout mice reveals pathways associated with Svep1 deficiency [0.03%]
深度血浆和组织蛋白质组谱分析敲除小鼠发现与Svep1缺陷相关通路
Colleen B Maxwell,Nikita Bhakta,Matthew J Denniff et al.
Colleen B Maxwell et al.
Despite strong causal associations with cardiovascular and metabolic disorders including coronary artery disease, hypertension, and type 2 diabetes, as well as a range of other diseases, the exact function of the protein SVEP1 remains large...
Cardiac growth patterns and metabolism before and after birth in swine: Role of miR in proliferation, hypertrophy and metabolism [0.03%]
猪出生前和出生后的心脏生长模式及代谢情况及其增殖、肥大和代谢中miR的作用规律
Catherine G Dimasi,Jack R T Darby,Stacey L Holman et al.
Catherine G Dimasi et al.
The adult mammalian heart is unable to undergo cardiac repair, limiting potential treatment options after cardiac damage. However, the fetal heart is capable of cardiac repair. In preparation for birth, cardiomyocytes (CMs) undergo major ma...
Application of adipose tissue-derived stem cell therapy with a clinically relevant dose does not significantly affect atherosclerotic plaque characteristics in a streptozotocin-induced hyperglycaemia mouse model [0.03%]
临床相关剂量的脂肪源性干细胞治疗不会显著影响链脲佐菌素诱导的高血糖小鼠模型动脉粥样硬化斑块特征
Amber Korn,Suat Simsek,Mitchell D Fiet et al.
Amber Korn et al.
Aims: Diabetes mellitus (DM) induces increased inflammation of atherosclerotic plaques, resulting in elevated plaque instability. Mesenchymal stem cell (MSC) therapy was shown to decrease plaque size and increase stabilit...
Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection [0.03%]
一种新型Drp1抑制剂心脏靶向投递的急性心肌保护作用
Jarmon G Lees,David W Greening,David A Rudd et al.
Jarmon G Lees et al.
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a cardiac-targe...
P-, E-, and H-cadherins differ in their relationships with coronary stenosis, cardiovascular outcomes, and unplanned recurrent revascularization [0.03%]
P-Cadherin、E-Cadherin和H-Cadherin与冠状动脉狭窄、心血管预后及不明原因的再次血运重建的关系不同
Nadezhda G Gumanova,Dmitry K Vasilyev,Natalya L Bogdanova et al.
Nadezhda G Gumanova et al.
Background and aims: Cadherins are adhesion proteins, and their dysregulation may result in the development of atherosclerosis, plaque rupture, or lesions of the vascular wall. The aim of the present study was to detect t...
Myocardial overexpression of protein phosphatase 2A-B56α improves resistance against ischemia-reperfusion injury [0.03%]
心肌过表达蛋白磷酸酶2A-B56α改善缺血再灌注损伤抵抗能力
Julius R Herting,Anna M Berg,Katarina Hadova et al.
Julius R Herting et al.
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit (PP2Ac) or exogenous in...
No cell fate conversion of macrophages to endothelial cells after myocardial infarction [0.03%]
心肌梗死后巨噬细胞不会转分化为内皮细胞
Zhengkai Lu,Lingfang Zhuang,Ruiyan Zhang et al.
Zhengkai Lu et al.