Integrated heart-blood RNA editome profiling reveals circulating A-to-I editing candidates linked to dilated cardiomyopathy myocardial signatures and heart failure [0.03%]
Korina Karagianni,Mantiana Topouzi,Ilektra Mitsi et al.
Korina Karagianni et al.
Background: Dilated cardiomyopathy (DCM) is a leading cause of heart failure (HF), yet molecular signatures that are detectable in blood and mechanistically anchored in myocardial pathology remain limited. Adenosine-to-in...
Deletion of Cd248 in Postn + myofibroblast fails to attenuate pressure-overload induced cardiac remodeling and fibrosis in mice [0.03%]
Donghua Li,Dongmei Zhong,Tian Tan et al.
Donghua Li et al.
Cardiac fibrosis driven by activated myofibroblasts is a central feature of pressure-overload heart disease. CD248 (Endosialin/TEM1) has been implicated as a pro-fibrotic marker in ischemic cardiac injury, but its role in pressure overload ...
RNA modifications in peripheral blood are associated with acute coronary syndrome [0.03%]
外周血的RNA修饰与急性冠脉综合征相关性研究
Miron Sopic,Victoria Stopa,Jelena Munjas et al.
Miron Sopic et al.
Acute coronary syndromes (ACS) trigger inflammatory and immune reactions, yet whether this response is associated with changes in RNA modifications remains poorly understood. We investigated global epitranscriptomic patterns in peripheral b...
Alyssa C Vadovsky,Eunji Jeong,Sandeep Banga et al.
Alyssa C Vadovsky et al.
Heart failure is chronic condition that is diagnosed when the heart is no longer able to pump enough blood to meet the physiological needs of the body. It is a progressive condition and typically manifests early on as exercise intolerance d...
Response of human iPSC-cardiomyocytes to adrenergic drugs assessed by high-throughput pericellular oxygen measurements and computational modeling [0.03%]
人诱导多能干细胞心肌细胞对肾上腺素药物的反应通过高通量细胞外氧测量和计算建模进行表征
Weizhen Li,M Amin Forouzandehmehr,David McLeod et al.
Weizhen Li et al.
Rate- and contractility-modulating drugs, such as adrenergic agonists and antagonists, are widely used in the treatment of cardiovascular conditions. Preclinical assessment of new modulators of rate, inotropy and metabolism can be aided by ...
Selective ROCK2 inhibition reduces microvascular obstruction but does not reduce myocardial infarction after ischaemia and reperfusion [0.03%]
选择性 ROCK2 抑制可减少缺血再灌注后的微血管阻塞但不能减少心肌梗死
Lucie Pearce,David He,Derek M Yellon et al.
Lucie Pearce et al.
Introduction: Myocardial ischaemia/reperfusion (I/R) injury causes infarction, microvascular obstruction (MVO), and haemorrhage. MVO, often driven by vasospasm, lacks effective therapy. The non-selective ROCK inhibitor fa...
SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition [0.03%]
SARS-CoV-2感染的心肌细胞坏死性凋亡通路上调，但未发现线粒体过渡孔开放现象
C Gross,S Chatterjee,B E Nilsson-Payant et al.
C Gross et al.
Cardiac involvement in patients infected with COVID-19, in terms of myocarditis and troponin release, is associated with higher mortality. However, the underlying mechanisms are poorly understood. Infection of cardiomyocytes derived from hu...
Persistently increased CaMKIIδ autophosphorylation mediates pathologic SR Ca loss in a murine model of Doxorubicin-induced cardiomyopathy [0.03%]
CaMKIIδ的自身磷酸化介导了多柔比星诱导的心肌病小鼠模型中病理性SR钙丢失
Anna-Lena Feder,Daniel Tarnowski,Anna-Maria Pfützenreuter et al.
Anna-Lena Feder et al.
Background: Doxorubicin (DOX)-induced cardiomyopathy (DICM) manifests as left ventricular (LV) systolic dysfunction. DOX triggers oxidative stress and CaMKIIδ activity in cardiac myocytes. CaMKIIδ activation leads to im...
Identification of circular RNA hsa-PHACTR4_0009 as a new class of biomarker for transposition of the great arteries [0.03%]
圆环RNA hsa-PHACTR4_0009作为动脉导管未闭的新生物标志物的鉴定
Neha Rawal,Anmol Gurgela,Snigdha Kumari et al.
Neha Rawal et al.
Dextro-Transposition of great arteries (d-TGA) is a cardiac birth anomaly with reversed anatomic position of the aorta and pulmonary artery, with a poor prognosis. The molecular aetiology of d-TGA remains elusive, possibly due to polygenic ...
Mitochondrial metabolic remodeling and multi-omics profiling identify plasma biomarkers of myocardial infarction [0.03%]
线粒体代谢重构及多组学分析鉴定出心肌梗死的血浆生物标志物
Selvam Paramasivan,Mitchell C Lock,Roberto A Barrero et al.
Selvam Paramasivan et al.
Mitochondrial dysfunction is a hallmark of myocardial infarction (MI), yet the molecular mechanisms linking metabolic reprogramming in the ischemic myocardium to systemic biomarker signatures remain incompletely understood. In this study, w...