Dynamic borax-crosslinked transparent and antifreezing tragacanth gum-glycerol hydrogel for biomedical use [0.03%]
用于生物医学的动态透明防冻白胶甘草糖-甘油水凝胶
Pardis Dadashi,Zahra Nazemi,Fatemeh Radmanesh et al.
Pardis Dadashi et al.
Multifunctional hydrogels that combine stretchability, adhesion, self-healing, and transparency maintain significant promise for biomedical applications such as electronic skin, wound dressings, and wearable devices. This study presents a n...
Microfluidic engineering of triple-responsive cystine-crosslinked microgels for mild-redox-triggered chemotherapy [0.03%]
用于温和氧化触发化疗的三响应型半胱氨酸交联微凝胶的微流体制造工程学研究
Marcin Mackiewicz,Malgorzata Palusinska,Tomasz S Kaminski
Marcin Mackiewicz
Stimuli-responsive microgels promise site-directed chemotherapy, yet most redox-sensitive carriers depend on poorly soluble disulfide crosslinkers and require intracellular glutathione (≥10 mM) to trigger release. In contrast, we introduce...
Integrating clinical challenges and nanotechnological based approaches for psoriasis therapy [0.03%]
基于临床挑战和纳米技术的银屑病治疗集成方法学研究进展
Ana Vitoria Pupo Silvestrini,Ualisson José da Silva,Milena Finazzi Morais et al.
Ana Vitoria Pupo Silvestrini et al.
Psoriasis is a chronic, inflammatory, immune-mediated, papulosquamous skin disease with diverse clinical phenotypes. It is frequently associated with cardiometabolic and rheumatologic comorbidities, as well as significant physical and psych...
Biomimetic Cu2+/Zn2+ bimetallic surface with glycocalyx-mimicking polymer for selective vascular cell regulation and enhanced hemocompatibility [0.03%]
仿生Cu2+/Zn2+双金属表面通过糖萼模拟聚合物实现血管细胞选择性调节和血液相容性增强
Shuaihang Guo,Shengen Gu,Qiulian Wu et al.
Shuaihang Guo et al.
The vascular endothelium represents the ideal hemocompatible interface, exhibiting unique capabilities to prevent thrombus formation while maintaining vascular homeostasis. To emulate these properties, we have developed a biomimetic surface...
Smart and injectable hydrogels for cancer treatment and other biomedical applications [0.03%]
用于癌症治疗和其他生物医学应用的智能可注射水凝胶
Kang Er Cheah,Pauline Shan Qing Yeoh,Khin Wee Lai et al.
Kang Er Cheah et al.
The tumor microenvironment (TME) has specific features distinct from normal tissues, making these stimuli suitable for responsive and localized therapy. Injectable hydrogels have been identified as promising site-specific drug delivery carr...
Multifunctional FeSN nanozyme-doped hydrogel: A promising strategy for antibacterial therapy and wound repair [0.03%]
多功能FeSN纳米酶掺杂水凝胶：一种有前景的抗菌治疗和伤口修复策略
Fuying Tu,Shengmiao Sun,Zhaoge Zhang et al.
Fuying Tu et al.
Nanozymes have emerged as a promising alternative to antibiotics owing to their broad-spectrum antibacterial activity and reduced risk of inducing drug resistance. However, their application in bacterial inhibition is often hindered by limi...
Design of 3D spheroid models for drug-response studies of HER2-targeted radiopharmaceuticals [0.03%]
HER2靶向放射性药物药效研究的3D球体模型设计
Ivan V Zelepukin,Lisa Fulterer,Ahmed D Elshazli et al.
Ivan V Zelepukin et al.
The development of targeted radionuclide- and chemotherapeutics-based drugs requires in vitro models that reflect the structural and molecular complexity of solid tumors. Here, we present a high-throughput 3D cell culture platform for targe...
Histatin-1 promotes bone regeneration by coordinating osteogenic and angiogenic responses in a sustained-release hydrogel system [0.03%]
组蛋白酸-1通过协调持续释放水凝胶系统中的成骨和成血管反应促进骨再生
Yi Zhu,Yiting Lou,Mengyuan Zhang et al.
Yi Zhu et al.
The regeneration of critical-sized bone defects is severely hampered by a dual challenge: insufficient vascularization and limited osteogenic activity at the injury site. Histatin-1 (Hst1), a salivary peptide with known pro-angiogenic and r...
Light-responsive phase-change nanoparticles for on-demand oxygen release to alleviate hypoxia for wound healing applications [0.03%]
一种用于按需释放氧气以缓解伤口愈合过程中缺氧的光响应相变纳米粒子
Pejman Ghaffari-Bohlouli,Ruo-Lan Shi,Qiong Xiang et al.
Pejman Ghaffari-Bohlouli et al.
Treatment strategies involving reactive oxygen species (ROS), such as chemodynamic and photodynamic therapies, have been explored for various applications, including inflammatory, infection-related, and cardiovascular disorders. However, th...
Bioactive cardiac ECM hydrogel sequentially released VEGF and Ang-1 mimic peptides to promote the recovery of myocardial infarction [0.03%]
生物活性心脏ECM水凝胶顺序释放VEGF和Ang-1模拟肽以促进心肌梗死恢复
Siqi Song,Lu Yang,Kaiyan Su et al.
Siqi Song et al.
Vascular endothelial growth factor (VEGF) based therapeutic angiogenesis provided a promising treatment for myocardial infarction (MI). As a critical coordinated factor, angiopoietin-1 (Ang-1) and its mimic peptide (AMP) were revealed to pr...