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Histatin-1 promotes bone regeneration by coordinating osteogenic and angiogenic responses in a sustained-release hydrogel system

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The regeneration of critical-sized bone defects is severely hampered by a dual challenge: insufficient vascularization and limited osteogenic activity at the injury site. Histatin-1 (Hst1), a salivary peptide with known pro-angiogenic and regenerative activiti... ...