Xiaoyu Zhang,Jian Wang,Wangxin Guo et al.
Xiaoyu Zhang et al.
Organ development, regeneration and cancer initiation are typically influenced by the proliferation and lineage plasticity of tissue-specific stem cells. Prostate intermediate cells, which exhibit characteristics of both basal and luminal c...
H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation [0.03%]
多能性维持和谱系分化中的H3K27me3介导的表观遗传调控
Liwen Jiang,Linfeng Huang,Wei Jiang
Liwen Jiang
Cell fate determination is an intricate process which is orchestrated by multiple regulatory layers including signal pathways, transcriptional factors, epigenetic modifications, and metabolic rewiring. Among the sophisticated epigenetic mod...
Stratifin-mediated activation of AKT signaling and therapeutic targetability in hepatocellular carcinoma progression [0.03%]
stratifen诱导的Akt信号活化及治疗靶点在肝细胞癌进展中的作用
Rong Hua,Kaitao Zhao,Zaichao Xu et al.
Rong Hua et al.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide and presents a significant threat to human health. Despite its prevalence, the underlying regulatory mechanisms of HCC remain unclear. In this stud...
ULI-ssDRIP-seq revealed R-loop dynamics during vertebrate early embryogenesis [0.03%]
ULI-ssDRIP-seq 揭示了脊椎动物早期胚胎发生过程中的R环动态变化
Wei Xu,Xin Liu,Jinjin Li et al.
Wei Xu et al.
R-loop, a chromatin structure containing one RNA:DNA hybrid and one unpaired single-stranded DNA, plays multiple biological roles. However, due to technical limitations, the landscapes and potential functions of R-loops during embryogenesis...
Hongyuan Qu,Yi Zhen,Mohan Xu et al.
Hongyuan Qu et al.
Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection [0.03%]
Helicobacter感染中Pyk2依赖的Par1b调节上皮细胞极性的控制作用
Irshad Sharafutdinov,Aileen Harrer,Mathias Müsken et al.
Irshad Sharafutdinov et al.
Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen Helicobacter pylori hijacks Par1b via the bacterial oncopr...
Baige Li,Ting Xie,Scott Nawy et al.
Baige Li et al.
The ciliary body, located at the junction of the choroid and iris, is crucial in the development of the embryonic eye. Notch2 signalling, Wnt signalling, transforming growth factor β (TGF-β) signalling, and Pax6 signalling are critical fo...
LUC7L3 is a downstream factor of SRSF1 and prevents genomic instability [0.03%]
LUC7L3是SRSF1的下游因子，可防止基因组不稳定
Xiaqing Zhang,Jing Guo,Xin Shi et al.
Xiaqing Zhang et al.
The RNA-binding protein LUC7L3 is the human homolog of yeast U1 small nuclear RNA (snRNA)-related splicing factor Luc7p. While the primary function of LUC7L3 as an RNA-binding protein is believed to be involved in RNA metabolism, particular...
Yang Yang,Yi-Zhen Chen,Tian Xia
Yang Yang
Tuberculosis (TB) remains a prevalent global infectious disease caused by genetically closely related tubercle bacilli in Mycobacterium tuberculosis complex (MTBC). For a century, the Bacillus Calmette-Guérin (BCG) vaccine has been the pri...
ACE2-using merbecoviruses: Further evidence of convergent evolution of ACE2 recognition by NeoCoV and other MERS-CoV related viruses [0.03%]
使用ACE2的默贝科病毒：NeoCoV和其他与MERS相关的病毒对ACE2识别趋同进化的进一步证据
Qing Xiong,Chengbao Ma,Chen Liu et al.
Qing Xiong et al.
Angiotensin-converting enzyme 2 (ACE2) was recognized as an entry receptor shared by coronaviruses from Sarbecovirus and Setracovirus subgenera, including three human coronaviruses: SARS-CoV, SARS-CoV-2, and NL63. We recently disclosed that...