Function and mechanism of bispecific antibodies targeting SARS-CoV-2 [0.03%]
靶向SARS-CoV-2的双特异性抗体的功能和机制
Zhaohui Li,Zengyuan Zhang,Steven T Rosen et al.
Zhaohui Li et al.
As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune e...
Lin He,Yiping Cao,Luyang Sun
Lin He
Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modification...
STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy [0.03%]
STING指导STX17-SNAP29-VAMP8复合物组装以控制自噬过程
Xiaoyu Song,Yufeng Xi,Ming Dai et al.
Xiaoyu Song et al.
The stimulator of interferon genes (STING) plays a pivotal role in orchestrating innate immunity, and dysregulated activity of STING has been implicated in the pathogenesis of autoimmune diseases. Recent findings suggest that bacterial infe...
Erratum regarding missing declaration of interests in previously published articles [0.03%]
关于先前已发表文章中缺失的利益冲突声明的勘误
[This corrects the article DOI: 10.1016/j.cellin.2022.100033.][This corrects the article DOI: 10.1016/j.cellin.2022.100031.][This corrects the article DOI: 10.1016/j.cellin.2022.100057.][This corrects the article DOI: 10.1016/j.cellin.2022....
Published Erratum
Cell insight. 2024 Jan 30;3(1):100148. DOI:10.1016/j.cellin.2024.100148 2024
Meiyue Dong,Jazmin M Galvan Achi,Ruikun Du et al.
Meiyue Dong et al.
The global outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatened human health and public safety. The development of anti-SARS-CoV-2 therapies have been essential to curb the spread of SARS-CoV-2. Particular...
Elafibranor emerged as a potential chemotherapeutic drug for non-muscle invasive bladder cancer [0.03%]
Elafibranor作为非肌肉侵袭性膀胱癌的潜在化疗药物崭露头角
Wang Wang,Danni Shan,Guanyi Wang et al.
Wang Wang et al.
Intravesical infusion of chemotherapeutics is highly recommended by several clinical guidelines for treating nonmuscle invasive bladder cancer (NMIBC). However, cytotoxic chemotherapeutics can cause a series of side effects, which greatly l...
Jinke Yang,Yue Wang,Yuanpan Hou et al.
Jinke Yang et al.
Brucella, an adept intracellular pathogen, causes brucellosis, a zoonotic disease leading to significant global impacts on animal welfare and the economy. Regrettably, there is currently no approved and effective vaccine for human use. The ...
Zhaocheng Zhai,Boqi Liu,Li Yu
Zhaocheng Zhai
Migrasomes are newly identified vesicular structures that mainly come from the ends and crosspoints of retracting fibers in moving cells. Their creation is closely linked with cell movement and goes through three key steps: Nucleation, Matu...
Jing Wu,Pan Gao,Yajing Shi et al.
Jing Wu et al.
CRISPR-Cas12a has been used for genome editing and molecular diagnosis. The well-studied Cas12a orthologs have a T-rich PAM and are usually categorized as non-thermally stable enzymes. Here, we identified a new Cas12a ortholog from Clostrid...
Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases [0.03%]
维持基因组的完整性：SUMO特异性泛素连接酶发挥的重要作用
Jinhua Han,Yanhua Mu,Jun Huang
Jinhua Han
Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs ...