Finding new roles of classic biomolecular condensates in the nucleus: Lessons from fission yeast [0.03%]
经典生物分子凝聚体在细胞核中的新作用：源于芽殖酵母的启示
Tomoyasu Sugiyama
Tomoyasu Sugiyama
Decades have passed since the initial discovery of membrane-less nuclear compartments, commonly called nuclear bodies or nuclear condensates. These compartments have drawn attention to their unique characteristics and functions, especially ...
Qiankun Wang,Liang Shan
Qiankun Wang
Human immunodeficiency virus (HIV) continues to be a significant global health challenge despite decades of research and advances in treatment. Substantial gaps in our understanding of the mechanisms of HIV pathogenesis and the host immune ...
Transcriptomic analysis of mouse TRAMP cell lines and tumors provide insights into shared pathways and therapeutic targets [0.03%]
小鼠TRAMP细胞系和肿瘤的转录组分析揭示了共享途径和治疗靶点的新见解
Marxa L Figueiredo,Sagar Utturkar,Shreya Kumar et al.
Marxa L Figueiredo et al.
The present study focused on comparing the gene expression profiles of different mouse models of prostate cancer, focusing on the TRAMP transgenic model and its derived cell lines and extending the comparisons to relevant genetically engine...
ATR/Chk1 interacting lncRNA modulates DNA damage response to induce breast cancer chemoresistance [0.03%]
调控DNA损伤反应以诱导乳腺癌化疗耐药的ATR/Chk1相互作用lncRNA
Rong Luo,Jiannan Wu,Xueman Chen et al.
Rong Luo et al.
The ATR-Chk1 pathway is essential in cellular responses to DNA damage and replication stress, whereas the role of long noncoding RNAs (lncRNAs) in regulating this pathway remains largely unknown. In this study, we identify an ATR and Chk1 i...
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death [0.03%]
GLUD1脱乙酰基作用通过抑制自噬性细胞死亡维持葡萄糖剥夺条件下肺腺癌细胞的存活
Qifan Hu,Longhua Sun,Zhujun Cheng et al.
Qifan Hu et al.
Enhanced glutamine catabolism is one of the main metabolic features of cancer, providing energy and intermediate metabolites for cancer progression. However, the functions of glutamine catabolism in cancer under nutrient deprivation need to...
Xue-Mei Yi,Ya-Li Lei,Mi Li et al.
Xue-Mei Yi et al.
Monkeypox virus (MPXV) is a DNA virus belonging to the Orthopoxvirus genus within the Poxviridae family which can cause a zoonotic infection. The unexpected non-endemic outbreak of mpox in 2022 is considered as a new global threat. It is im...
Xiaoyu Zhang,Jian Wang,Wangxin Guo et al.
Xiaoyu Zhang et al.
Organ development, regeneration and cancer initiation are typically influenced by the proliferation and lineage plasticity of tissue-specific stem cells. Prostate intermediate cells, which exhibit characteristics of both basal and luminal c...
H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation [0.03%]
多能性维持和谱系分化中的H3K27me3介导的表观遗传调控
Liwen Jiang,Linfeng Huang,Wei Jiang
Liwen Jiang
Cell fate determination is an intricate process which is orchestrated by multiple regulatory layers including signal pathways, transcriptional factors, epigenetic modifications, and metabolic rewiring. Among the sophisticated epigenetic mod...
Stratifin-mediated activation of AKT signaling and therapeutic targetability in hepatocellular carcinoma progression [0.03%]
stratifen诱导的Akt信号活化及治疗靶点在肝细胞癌进展中的作用
Rong Hua,Kaitao Zhao,Zaichao Xu et al.
Rong Hua et al.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide and presents a significant threat to human health. Despite its prevalence, the underlying regulatory mechanisms of HCC remain unclear. In this stud...
ULI-ssDRIP-seq revealed R-loop dynamics during vertebrate early embryogenesis [0.03%]
ULI-ssDRIP-seq 揭示了脊椎动物早期胚胎发生过程中的R环动态变化
Wei Xu,Xin Liu,Jinjin Li et al.
Wei Xu et al.
R-loop, a chromatin structure containing one RNA:DNA hybrid and one unpaired single-stranded DNA, plays multiple biological roles. However, due to technical limitations, the landscapes and potential functions of R-loops during embryogenesis...