The cell autonomous and non-autonomous roles of itaconate in immune response [0.03%]
衣康酸在免疫反应中的自主和非自主作用
Chao Chen,Xinjian Li
Chao Chen
Itaconate which is discovered as a mammalian metabolite possessing antimicrobial and immunoregulatory activity has attracted much attention in the field of immunometabolism. Itaconate is synthesized by myeloid cells under conditions of path...
APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs [0.03%]
APC通过正向调节KIF2A和负向调节CLASP调控微管动力学
Yong Wang,Xinping Liu,Zheng Liu et al.
Yong Wang et al.
Tumor suppressor protein Adenomatous polyposis coli protein (APC) is an EB-binding and microtubule (MT) plus end-tracking protein; however, how exactly APC regulates MT dynamics remains elusive. Here, we show that in LLC-PK1 cells, APC and ...
Ke-Jing Li,Lei Qi,Ying-Xuan Zhu et al.
Ke-Jing Li et al.
While genomic alterations are fundamental to biological evolution, enabling adaptation and diversity, they can also result in detrimental outcomes, such as the development of genetic diseases including cancer. The budding yeast Saccharomyce...
Transcripts derived from the neocortical enhancer of Ctnnb1 promote the enhancer-promoter interaction and maintain Ctnnb1 transcription [0.03%]
由Ctnnb1的新皮层增强子衍生的转录本促进增强子-启动子相互作用并维持Ctnnb1转录
Chen Zhao,Liang Wang,Junbao Wang et al.
Chen Zhao et al.
Qiu Pan,Xiao-Lian Zhang
Qiu Pan
Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals. Research over...
Just a SNP away: The future of in vivo massively parallel reporter assay [0.03%]
一步之遥：体内大规模平行报告基因检测的未来方向
Katherine N Degner,Jessica L Bell,Sean D Jones et al.
Katherine N Degner et al.
The human genome is largely noncoding, yet the field is still grasping to understand how noncoding variants impact transcription and contribute to disease etiology. The massively parallel reporter assay (MPRA) has been employed to character...
Phase-separated chromatin compartments: Orchestrating gene expression through condensation [0.03%]
分相染色质区室：通过凝聚调控基因表达
Xin Li,Chengzhi Liu,Zhichao Lei et al.
Xin Li et al.
Eukaryotic genomes are organized into distinct chromatin compartments, some of which exhibit properties of biomolecular condensates. These condensates primarily form due to chromatin-associated proteins/complexes (CAPs). CAPs play a crucial...
The role of SUMOylation in biomolecular condensate dynamics and protein localization [0.03%]
SUMO化在生物分子凝聚体动力学和蛋白质定位中的作用
Emily Gutierrez-Morton,Yanchang Wang
Emily Gutierrez-Morton
As a type of protein post-translational modification, SUMOylation is the process that attaches a small ubiquitin-like modifier (SUMO) to lysine residues of protein substrates. Not only do SUMO and ubiquitin exhibit structure similarity, but...
Modeling respiratory tract diseases for clinical translation employing conditionally reprogrammed cells [0.03%]
基于条件重编程细胞的呼吸道疾病临床转化模型
Danyal Daneshdoust,Kai He,Qi-En Wang et al.
Danyal Daneshdoust et al.
Preclinical models serve as indispensable tools in translational medicine. Specifically, patient-derived models such as patient-derived xenografts (PDX), induced pluripotent stem cells (iPSC), organoids, and recently developed technique of ...
Rajnish Kumar Singh,Atharva S Torne,Erle S Robertson
Rajnish Kumar Singh
Hypoxic reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) refers to the phenomenon under low oxygen where the virus goes from latent to lytic replication. Typically, healthy cells generally cease cell division and DNA replicati...