Qiu Pan,Xiao-Lian Zhang
Qiu Pan
Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals. Research over...
Just a SNP away: The future of in vivo massively parallel reporter assay [0.03%]
一步之遥：体内大规模平行报告基因检测的未来方向
Katherine N Degner,Jessica L Bell,Sean D Jones et al.
Katherine N Degner et al.
The human genome is largely noncoding, yet the field is still grasping to understand how noncoding variants impact transcription and contribute to disease etiology. The massively parallel reporter assay (MPRA) has been employed to character...
Phase-separated chromatin compartments: Orchestrating gene expression through condensation [0.03%]
分相染色质区室：通过凝聚调控基因表达
Xin Li,Chengzhi Liu,Zhichao Lei et al.
Xin Li et al.
Eukaryotic genomes are organized into distinct chromatin compartments, some of which exhibit properties of biomolecular condensates. These condensates primarily form due to chromatin-associated proteins/complexes (CAPs). CAPs play a crucial...
The role of SUMOylation in biomolecular condensate dynamics and protein localization [0.03%]
SUMO化在生物分子凝聚体动力学和蛋白质定位中的作用
Emily Gutierrez-Morton,Yanchang Wang
Emily Gutierrez-Morton
As a type of protein post-translational modification, SUMOylation is the process that attaches a small ubiquitin-like modifier (SUMO) to lysine residues of protein substrates. Not only do SUMO and ubiquitin exhibit structure similarity, but...
Modeling respiratory tract diseases for clinical translation employing conditionally reprogrammed cells [0.03%]
基于条件重编程细胞的呼吸道疾病临床转化模型
Danyal Daneshdoust,Kai He,Qi-En Wang et al.
Danyal Daneshdoust et al.
Preclinical models serve as indispensable tools in translational medicine. Specifically, patient-derived models such as patient-derived xenografts (PDX), induced pluripotent stem cells (iPSC), organoids, and recently developed technique of ...
Rajnish Kumar Singh,Atharva S Torne,Erle S Robertson
Rajnish Kumar Singh
Hypoxic reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) refers to the phenomenon under low oxygen where the virus goes from latent to lytic replication. Typically, healthy cells generally cease cell division and DNA replicati...
The methyltransferase SETD3 regulates mRNA alternative splicing through interacting with hnRNPK [0.03%]
甲基转移酶SETD3通过与hnRNPK互作调控mRNA剪接
Yue-Yu Kong,Wen-Jie Shu,Shuang Wang et al.
Yue-Yu Kong et al.
The methyltransferase SETD3 is an enzyme essential for catalyzing histidine-73 methylation on β-Actin, thereby promoting its polymerization and regulating muscle contraction. Although increasing evidence suggests that SETD3 is involved in ...
Aoqun Song,Yunting Wang,Cuifang Liu et al.
Aoqun Song et al.
During the development of eukaryote, faithful inheritance of chromatin states is central to the maintenance of cell fate. DNA replication poses a significant challenge for chromatin state inheritance because every nucleosome in the genome i...
Jianying Liu,Yixin Quan,Hua Tong et al.
Jianying Liu et al.
The increasing global prevalence of mosquito-borne viruses has emerged as a significant threat to human health and life. Identifying receptors for these viruses is crucial for improving our knowledge of viral pathogenesis and developing eff...
Lianxin Hu,Qing Zhang
Lianxin Hu
TANK-binding kinase 1 (TBK1) is a serine/threonine kinase with well-established roles as a central player in innate immune signaling. Dysregulation of TBK1 activity has been implicated in a variety of pathophysiologic conditions, including ...