The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival [0.03%]
沙门氏菌与宿主的相互作用：细菌存活的机制和策略
Hongyu Zhao,Xinyue Zhang,Ningning Zhang et al.
Hongyu Zhao et al.
Salmonella, an intracellular pathogen, infects both humans and animals, causing diverse diseases such as gastroenteritis and enteric fever. The Salmonella type III secretion system (T3SS), encoded within its pathogenicity islands (SPIs), is...
Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis [0.03%]
利用整合基因组和转录组分析揭示前列腺癌中的种族差异现象
Abdalla Elbialy,Akshay Sood,Shang-Jui Wang et al.
Abdalla Elbialy et al.
Prostate cancer exhibits significant racial disparities, with African American (AA) individuals showing ∼64% higher incidence and 2.3 times greater mortality rates compared to their Caucasian (CA) counterparts. Understanding the complex in...
Structure-Guided design of Cas12a variants improves detection of nucleic acids [0.03%]
结构导向设计Cas12a变体可改善对核酸的检测
Xiaohan Tong,Tianle Li,Kun Zhang et al.
Xiaohan Tong et al.
CRISPR-Cas12a holds promising potential for pathogen detection. However, its performance is not optimal when combined with isothermal amplification. Hence, we engineered a mutant of LbCas12a (K595A) with reduced cis-cleavage activity, to mi...
The promising role of nanopore sequencing in cancer diagnostics and treatment [0.03%]
纳米孔测序在癌症诊断和治疗中的重要作用展望
Xinming Su,Qingyuan Lin,Bin Liu et al.
Xinming Su et al.
Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a powerful means of detecting these alterations due to its unique capacity for long single-molecule sequenci...
Cedar virus biology and its applications as a surrogate for highly pathogenic henipaviruses [0.03%]
雪松病毒的生物学及其作为高度病原性亨尼帕病毒替代物的应用
Ahmad Jawad Sabir,Lijun Rong,Christopher C Broder et al.
Ahmad Jawad Sabir et al.
Nipah Virus (NiV) and Hendra Virus (HeV), are the prototype species of the genus Henipavirus and are highly pathogenic agents capable of causing fatal diseases in both animals and humans. Both NiV and HeV are classified as biosafety level-4...
The role of colonic microbiota amino acid metabolism in gut health regulation [0.03%]
结肠菌群氨基酸代谢在肠道健康调节中的作用
Youli Chen,Jing-Yuan Fang
Youli Chen
The human gut microbiota plays a critical role in maintaining host homeostasis through metabolic activities. Among these, amino acid (AA) metabolism by the microbiota in the large intestine is highly heterogeneous and relevant to host healt...
Rui-Jin Ji,Mu-Yao Wang,Ying Zhang
Rui-Jin Ji
The ability to recognize antigen epitope is crucial for generating an effective immune response. By engineering these epitopes, researchers can reduce on-target/off-tumor toxicity associated with targeted immunotherapy. Recent studies indic...
Inflammatory signatures of microglia in hypercortisolemia-related depression [0.03%]
高皮质醇血症相关抑郁小胶质细胞炎症表型及功能重塑机制研究
Yanxiang Zhao,Yingying Huang,Zhangyuzi Deng et al.
Yanxiang Zhao et al.
[This corrects the article DOI: 10.1016/j.cellin.2022.100030.][This corrects the article DOI: 10.1016/j.cellin.2023.100089.][This corrects the article DOI: 10.1016/j.cellin.2022.100016.][This corrects the article DOI: 10.1016/j.cellin.2022....
Published Erratum
Cell insight. 2025 Jan 11;4(2):100225. DOI:10.1016/j.cellin.2024.100225 2025
Progress in photoreceptor replacement therapy for retinal degenerative diseases [0.03%]
视网膜退行性疾病光受体替代治疗研究进展
Yuxin Du,Yin Shen
Yuxin Du
Retinal degenerative diseases encompass a diverse range of eye conditions that result in blindness, many due to photoreceptor dysfunction and loss. Regrettably, current clinical treatments are frequently not overly effective. However, photo...