IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner [0.03%]
IRF1以正反馈方式放大HSV-1触发的抗病毒先天免疫反应
Ming Gao,Yining Qi,Junjie Zhang
Ming Gao
Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that establishes lifelong infection and causes a wide range of diseases. Antiviral innate immunity is critical for controlling HSV-1 replication; however, how host cells elicit a ...
Rapid and direct discovery of functional tumor specific neoantigens by high resolution mass spectrometry and novel algorithm prediction [0.03%]
基于高分辨率质谱和新型算法预测的快速直接发现功能性肿瘤新抗原
Huajian Tian,Guifei Li,Cookson K C Chiu et al.
Huajian Tian et al.
While immune cell therapies have transformed cancer treatment, achieving comparable success in solid tumors remains a significant challenge compared to hematologic malignancies like non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). Over...
Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways [0.03%]
单细胞测序和糖尿病肾脏空间多组学分段见解：具有区带特异性的治疗代谢途径
Shi Qiu,Zhibo Wang,Sifan Guo et al.
Shi Qiu et al.
Diabetic nephropathy (DN) exhibits profound spatial metabolic heterogeneity across kidney regions, yet how compartmentalized pathways drive disease progression remains poorly defined. A deeper understanding of the organizational spatial env...
Yutong Liu,Pinglong Xu
Yutong Liu
Cyclic GMP-AMP synthase (cGAS) functions as a pivotal intracellular sensor for the innate immune sensing of double-stranded DNA (dsDNA), monitoring those nucleic acids from foreign and endogenous sources. Upon assembling into cellular conde...
The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption [0.03%]
瞬时受体电位通道V4在急性睡眠剥夺引起的记忆损伤中的作用：钙失调和突触可塑性损伤的机制研究
Meimei Guo,Feiyang Zhang,Sha Liu et al.
Meimei Guo et al.
Acute sleep deprivation (ASD) impairs memory formation, but the underlying mechanisms remain unclear. In this study, we employed an ASD model combined with fear conditioning to investigate these mechanisms. mRNA sequencing revealed upregula...
Corrigendum to "STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy" [Cell Insight 3 (2024) 100147] [0.03%]
关于“STING引导STX17-SNAP29-VAMP8复合体组装以控制自噬”一文的勘误CELL INSIGHT 3 (2024) 100147]
Xiaoyu Song,Yufeng Xi,Ming Dai et al.
Xiaoyu Song et al.
[This corrects the article DOI: 10.1016/j.cellin.2024.100147.]. © 2025 The Author(s).
Published Erratum
Cell insight. 2025 Apr 11;4(3):100239. DOI:10.1016/j.cellin.2025.100239 2025
The interplay between Salmonella and host: Mechanisms and strategies for bacterial survival [0.03%]
沙门氏菌与宿主的相互作用：细菌存活的机制和策略
Hongyu Zhao,Xinyue Zhang,Ningning Zhang et al.
Hongyu Zhao et al.
Salmonella, an intracellular pathogen, infects both humans and animals, causing diverse diseases such as gastroenteritis and enteric fever. The Salmonella type III secretion system (T3SS), encoded within its pathogenicity islands (SPIs), is...
Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis [0.03%]
利用整合基因组和转录组分析揭示前列腺癌中的种族差异现象
Abdalla Elbialy,Akshay Sood,Shang-Jui Wang et al.
Abdalla Elbialy et al.
Prostate cancer exhibits significant racial disparities, with African American (AA) individuals showing ∼64% higher incidence and 2.3 times greater mortality rates compared to their Caucasian (CA) counterparts. Understanding the complex in...
Structure-Guided design of Cas12a variants improves detection of nucleic acids [0.03%]
结构导向设计Cas12a变体可改善对核酸的检测
Xiaohan Tong,Tianle Li,Kun Zhang et al.
Xiaohan Tong et al.
CRISPR-Cas12a holds promising potential for pathogen detection. However, its performance is not optimal when combined with isothermal amplification. Hence, we engineered a mutant of LbCas12a (K595A) with reduced cis-cleavage activity, to mi...
The promising role of nanopore sequencing in cancer diagnostics and treatment [0.03%]
纳米孔测序在癌症诊断和治疗中的重要作用展望
Xinming Su,Qingyuan Lin,Bin Liu et al.
Xinming Su et al.
Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a powerful means of detecting these alterations due to its unique capacity for long single-molecule sequenci...