Development of a comparative high-throughput screening platform for identifying glioblastoma subtype specific inhibitors [0.03%]
一种比较型高通量筛选平台的开发用于鉴定胶质母细胞瘤亚群特异性抑制剂
Zilai Wang,Pin Zhang,Kiira M Ratia et al.
Zilai Wang et al.
Glioblastoma (GBM) is the most lethal primary malignant brain tumor in adults, with the development of effective therapeutic agents largely hampered by vast tumor heterogeneity and the impedance of efficient drug delivery by the blood-brain...
Loop engineering of AtCas9 for effective and broad genome editing [0.03%]
用于有效且广泛基因组编辑的AtCas9蛋白的环路改造工程
Yue-Lin Zhang,Dong-Chao Huang,Min Duan et al.
Yue-Lin Zhang et al.
Efficient genome editing in mammalian cells is essential for CRISPR-based therapeutics. While extensive efforts focused on combining multiple beneficial point mutations to enhance Cas9 activity, the potential of engineering surface-exposed ...
Jianglong Yu,Yuanchun Luo,Jiacheng Lin et al.
Jianglong Yu et al.
Mitochondrial cristae are the principal sites of oxidative phosphorylation and are central to mitochondria-dependent energy metabolism. Rather than static folds, cristae are dynamic bioenergetic compartments that remodel in response to phys...
Hypoxia-induced MT2A-tetrameric PKM2 interaction maintains PKM2 activity in a copper-ion-dependent manner [0.03%]
缺氧诱导的MT2A四聚体PKM2相互作用以铜离子依赖性方式维持PKM2活性
Ronghui Gao,Qifang Li,Jiahao Guo et al.
Ronghui Gao et al.
Hypoxia is a hallmark of solid tumors associated with tumor malignancy. Mitochondrial metabolic reprogramming is a key step in the process of cellular adaptation to hypoxic stress for tumor growth, but the regulatory mechanisms are not full...
Host-virus molecular arms race: RNAi-mediated antiviral defense and viral suppressor of RNAi [0.03%]
宿主病毒分子“军备竞赛”：RNA干扰介导的抗病毒防御和病毒RNA干扰抑制蛋白
Bowen Zhang,Xi Zhou,Yujie Ren
Bowen Zhang
RNA interference (RNAi) is a highly conserved post-transcriptional gene silencing (PTGS) mechanism widely presented in eukaryotes. During viral infection, double-stranded RNA viral replicative intermediate (vRI-dsRNA) derived from the viral...
Liting Zhang,Chuchu Zhang,Junjie Zhang
Liting Zhang
Mediator of IRF3 activation (MITA)/Stimulator of Interferon Genes (STING) (also known as MPYS/ERIS) is a crucial adaptor protein for initiating antiviral innate immune responses to intracellular DNA and DNA viruses. MITA binds cGAMP, a seco...
PAK4 phosphorylates and stabilizes MYC to promote acute myeloid leukemia [0.03%]
PAK4通过使MYC磷酸化并稳定来促进急性髓系白血病的发展
Ting Xie,Peipei Sun,Hao Huang et al.
Ting Xie et al.
MYC dysregulation plays a crucial role in acute myeloid leukemia (AML), yet the mechanisms governing its stabilization remain incompletely understood. MYC protein turnover is tightly regulated by post-translational modifications (PTMs), esp...
Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast [0.03%]
忠实的继承：模式真菌中父母代组蛋白的循环再利用和表观遗传记忆
Yimeng Fang,Takenori Toda,Songtao Jia
Yimeng Fang
Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled an...
Microbiota-derived bile acid metabolic enzymes and their impacts on host health [0.03%]
微生物群衍生的胆酸代谢酶及其对宿主健康的影响
Haohan Ma,Kai Wang,Changtao Jiang
Haohan Ma
Bile acids are amphipathic sterol molecules regulated by both the host and gut microbiota, serving as classical mediators for deciphering host-microbiota interactions. Synthesized primarily in the liver and undergoing extensive structural m...
The roles of macrophages and monocytes in COVID-19 Severe Respiratory Syndrome [0.03%]
巨噬细胞和单核细胞在COVID-19重症呼吸系统综合症中的作用
Jun Li,Rui Shan,Heather Miller et al.
Jun Li et al.
The global COVID-19 pandemic has highlighted the pivotal role of the immune system in the development of severe respiratory symptoms, termed COVID-19 Severe Respiratory Syndrome (COVID-19-SR). This review aims to dissect the involvement of ...