Host-virus molecular arms race: RNAi-mediated antiviral defense and viral suppressor of RNAi [0.03%]
宿主病毒分子“军备竞赛”：RNA干扰介导的抗病毒防御和病毒RNA干扰抑制蛋白
Bowen Zhang,Xi Zhou,Yujie Ren
Bowen Zhang
RNA interference (RNAi) is a highly conserved post-transcriptional gene silencing (PTGS) mechanism widely presented in eukaryotes. During viral infection, double-stranded RNA viral replicative intermediate (vRI-dsRNA) derived from the viral...
Liting Zhang,Chuchu Zhang,Junjie Zhang
Liting Zhang
Mediator of IRF3 activation (MITA)/Stimulator of Interferon Genes (STING) (also known as MPYS/ERIS) is a crucial adaptor protein for initiating antiviral innate immune responses to intracellular DNA and DNA viruses. MITA binds cGAMP, a seco...
PAK4 phosphorylates and stabilizes MYC to promote acute myeloid leukemia [0.03%]
PAK4通过使MYC磷酸化并稳定来促进急性髓系白血病的发展
Ting Xie,Peipei Sun,Hao Huang et al.
Ting Xie et al.
MYC dysregulation plays a crucial role in acute myeloid leukemia (AML), yet the mechanisms governing its stabilization remain incompletely understood. MYC protein turnover is tightly regulated by post-translational modifications (PTMs), esp...
Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast [0.03%]
忠实的继承：模式真菌中父母代组蛋白的循环再利用和表观遗传记忆
Yimeng Fang,Takenori Toda,Songtao Jia
Yimeng Fang
Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled an...
Microbiota-derived bile acid metabolic enzymes and their impacts on host health [0.03%]
微生物群衍生的胆酸代谢酶及其对宿主健康的影响
Haohan Ma,Kai Wang,Changtao Jiang
Haohan Ma
Bile acids are amphipathic sterol molecules regulated by both the host and gut microbiota, serving as classical mediators for deciphering host-microbiota interactions. Synthesized primarily in the liver and undergoing extensive structural m...
The roles of macrophages and monocytes in COVID-19 Severe Respiratory Syndrome [0.03%]
巨噬细胞和单核细胞在COVID-19重症呼吸系统综合症中的作用
Jun Li,Rui Shan,Heather Miller et al.
Jun Li et al.
The global COVID-19 pandemic has highlighted the pivotal role of the immune system in the development of severe respiratory symptoms, termed COVID-19 Severe Respiratory Syndrome (COVID-19-SR). This review aims to dissect the involvement of ...
The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages [0.03%]
NF-κB-SLC7A11轴调节炎性巨噬细胞的铁死亡敏感性
Mengjie Yang,Xiaowei Chen,Xiran Hu et al.
Mengjie Yang et al.
M1-polarized macrophages exhibit remarkable resistance to ferroptosis, a form of regulated cell death driven by excessive lipid peroxidation. Yet the underlying mechanisms remain to be defined. Through CRISPR-based functional screen of meta...
Yaobin Jing,Jie Ren,Jing Qu et al.
Yaobin Jing et al.
Aging is characterized by a progressive decline in organ and tissue structure and function, significantly increasing the risk of many chronic diseases. Developing interventions to delay aging holds the potential to reduce the burden of age-...
TFAP4 exacerbates pathological cardiac fibrosis by modulating mechanotransduction [0.03%]
TFAP4通过调节机械转导加重病理性心脏纤维化
Jie Liu,Jingjing Feng,Jingxuan Zhao et al.
Jie Liu et al.
Cardiac fibroblast (CF) differentiation into myofibroblasts is a crucial driver of cardiac fibrosis, leading to extensive extracellular matrix (ECM) deposition that increases myocardial stiffness and eventually impairs heart function. Mecha...
Integrated 4D label-free proteome and SUMOylated proteome in glioma uncover novel pathological mechanisms and pave the way for precision therapy [0.03%]
整合的4D无标签蛋白质组和SUMO修饰蛋白质组揭示胶质瘤新病理机制并为精准治疗铺路
Jiazheng Wang,Zhuo Li,Kaijie Mu et al.
Jiazheng Wang et al.
Glioma, the most common primary intracranial tumor, has seen increased scrutiny with the advent of high-throughput detection technologies, yet many aspects of its tumorigenesis and progression remain enigmatic. In this study, we utilized 4D...