Tuning the state: Matching condensate material properties with physiological demands and pathological dysfunction [0.03%]
调适状态：使凝聚物质的特性与生理需求及病理异常相匹配
Jingxuan Luo,Zhehao Li,Ziyin Shen et al.
Jingxuan Luo et al.
Biomolecular condensates have emerged as fundamental organizers of cellular biochemistry. Increasing evidence indicates that cellular condensates exhibit a broad spectrum of material properties-including viscoelastic, soft glass-like, gel-l...
Phosphorylation of FBXL3 mediates GLDC polyubiquitination to suppress MHC-I expression and promote cancer immune evasion [0.03%]
FBXL3的磷酸化介导GLDC的多泛素化以抑制MHC-I表达并促进癌症免疫逃逸
Rui Liu,Shu Li
Rui Liu
Glycine decarboxylase (GLDC) is overexpressed in multiple tumor types and contributes to tumorigenesis or immune evasion by unclarified mechanisms. Here we report that GLDC is polyubiquitinated at K636 following EGFR activation, which drive...
Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation [0.03%]
ADAR1介导的RNA编辑和免疫调节的结构与机制基础
Xiangyu Deng,Mariam Elsharkawy,Yang Gao
Xiangyu Deng
Adenosine deaminase acting on RNA 1 (ADAR1) is a central regulator of innate immunity. By binding to and catalyzing adenosine-to-inosine deamination within double-stranded RNAs, ADAR1 mitigates the immunogenicity of self-derived RNAs and pr...
Tongmei Zhang,Weihong Song
Tongmei Zhang
An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy [0.03%]
MITA/STING_gain_of_function突变体中的附加位点突变消除了自身免疫SAVI表型并指导了治疗策略
Fang-Xu Li,Sheng Liu,Zhi-Dong Zhang et al.
Fang-Xu Li et al.
STING-associated vasculopathy with onset in infancy (SAVI) is an autoimmune disease caused by gain-of-function mutations (GOFs) of MITA/STING and the most frequent GOFs for SAVI are MITAN154S and MITAV155M. However, how MITA GOFs are sponta...
Host-pathogen interactions in African swine fever: From viral entry to systemic disease progression [0.03%]
非洲猪瘟的宿主病原体互作：从病毒入侵到全身性发病进展
Danyang Zhang,Shilei Zhang,Fayu Yang et al.
Danyang Zhang et al.
African swine fever virus (ASFV), a large and complex double-stranded DNA virus, is the etiological agent of African swine fever (ASF). ASF is a highly contagious and lethal hemorrhagic disease in domestic swine, which poses a persistent th...
Corrigendum to "The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption." [Cell Insight 4 (2025) 100240] [0.03%]
关于“瞬时受体电位通道V4在急性睡眠剥夺引起的记忆障碍中的作用：钙调节紊乱和突触可塑性破坏的机制”的勘误[(细胞洞察力 4 (2025) 100240)]
Meimei Guo,Feiyang Zhang,Sha Liu et al.
Meimei Guo et al.
[This corrects the article DOI: 10.1016/j.cellin.2025.100240.]. © 2025 The Author(s).
Published Erratum
Cell insight. 2025 Dec 24;5(1):100296. DOI:10.1016/j.cellin.2025.100296 2025
Hydrophobic tagging: A promising paradigm for targeted protein degradation [0.03%]
疏水标记：一种前景广阔的靶向蛋白质降解范式
Lilan Xin,Hongli Wang,Maoze Yang et al.
Lilan Xin et al.
Targeted protein degradation (TPD) has emerged as a groundbreaking therapeutic strategy, overcoming the limitations of traditional occupancy-driven pharmacology. Among TPD strategies, hydrophobic tag (HyT) technology exemplifies this paradi...
HTATSF1 regulates innate antiviral immune response by orchestrating TRAF3-IRF3 and TRAF6-NF-κB pathways [0.03%]
HTATSF1通过调控TRAF3-IRF3和TRAF6-NF-κB通路调节先天性抗病毒免疫应答
Jia-Qing Zeng,Zi-Lun Ruan,Qi Zhang et al.
Jia-Qing Zeng et al.
Upon infection, viral DNA/RNA is detected by cGAS/RIG-I-like receptors, triggering the adaptor MITA/STING- or VISA/MAVS-dependent innate antiviral immune response respectively. Both adaptors recruit the conserved TRAF3 and TRAF6 to activate...
CXCL4 and CXCL4L1 activate human macrophage via TLR4 signaling to modulate inflammatory responses [0.03%]
CXCL4和CXCL4L1通过TLR4信号激活人类巨噬细胞以调节炎症反应
Han Bai,Ruoxi Yuan,Dong Yan et al.
Han Bai et al.
The chemokine CXCL4 activates human monocytes/macrophages and contributes to the pathogenesis of inflammatory and fibrotic diseases. However, the receptor of CXCL4, CXCR3, is not expressed in human monocytes/macrophages. Thus, signaling pat...