Dong Guo,Ying Meng,Xiaoming Jiang et al.
Dong Guo et al.
Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal roles in glucose metabolism through canonical functions of hexokinases as well as in immune response, cell stemness, autophagy, and other cellular ac...
Atlas of interactions between SARS-CoV-2 macromolecules and host proteins [0.03%]
SARS-CoV-2大型分子与宿主蛋白相互作用图集
Guangnan Li,Zhidong Tang,Weiliang Fan et al.
Guangnan Li et al.
The proteins and RNAs of viruses extensively interact with host proteins after infection. We collected and reanalyzed all available datasets of protein-protein and RNA-protein interactions related to SARS-CoV-2. We investigated the reproduc...
Intertwined regulation between RNA m6A modification and cancer metabolism [0.03%]
RNA m6A修饰与癌症代谢的相互调控关系研究进展
Jiaxu Liu,Hao Huang,Minghao Zhang et al.
Jiaxu Liu et al.
RNA N6-methyladenosine (m6A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). Accumulating evidence demonstrates that RNA m6A modif...
Structural basis of the TCR-pHLA complex provides insights into the unconventional recognition of CDR3β in TCR cross-reactivity and alloreactivity [0.03%]
TCR-pHLA复合物的结构基础提供了关于TCR交叉反应和同种反应中非传统识别CDR3β的见解
Dan San,Jun Lei,Yang Liu et al.
Dan San et al.
Evidence shows that some class I human leucocyte antigen (HLA) alleles are related to durable HIV controls. The T18A TCR, which has the alloreactivity between HLA-B∗42:01 and HLA-B∗81:01 and the cross-reactivity with different antigen mut...
Screening of SARS-CoV-2 antivirals through a cell-based RNA-dependent RNA polymerase (RdRp) reporter assay [0.03%]
基于细胞的RNA依赖性RNA聚合酶(RdRp)报告基因测定筛选SARS-CoV-2抗病毒药物
Timsy Uppal,Kai Tuffo,Svetlana Khaiboullina et al.
Timsy Uppal et al.
COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2) continues to pose an international public health threat and thus far, has resulted in greater than 6.4 million deaths worldwide. Vacc...
USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network [0.03%]
USP2通过抑制髓系细胞增殖和重塑细胞外基质网络促进实验性结肠炎和细菌感染
Ran An,Peng Wang,Hao Guo et al.
Ran An et al.
Inflammatory bowel disease (IBD) is closely associated with dysregulation of genetic factors and microbial environment. Here, we report a susceptible role of ubiquitin-specific protease 2 (USP2) in experimental colitis and bacterial infecti...
Human adenoviruses: A suspect behind the outbreak of acute hepatitis in children amid the COVID-19 pandemic [0.03%]
人腺病毒可能是急性肝炎儿童病例激增的罪魁祸首
Hongyun Wang,Shimin Yang,Jiejie Liu et al.
Hongyun Wang et al.
As of 10 May 2022, at least 450 cases of pediatric patients with acute hepatitis of unknown cause have been reported worldwide. Human adenoviruses (HAdVs) have been detected in at least 74 cases, including the F type HAdV41 in 18 cases, whi...
Signaling and functions of interleukin-33 in immune regulation and diseases [0.03%]
细胞因子白介素33在免疫调节和疾病中的信号转导及功能
Xue-Mei Yi,Huan Lian,Shu Li
Xue-Mei Yi
Interleukin-33 (IL-33) which belongs to the interleukin-1 (IL-1) family is an alarmin cytokine with critical roles in tissue homeostasis, pathogenic infection, inflammation, allergy and type 2 immunity. IL-33 transmits signals through its r...
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity [0.03%]
STYK1 磷酸化抑制EGFR对自噬诱导和表皮生长因子受体酪氨酸激酶抑制剂敏感性的作用
Cefan Zhou,Xueying Dong,Ming Wang et al.
Cefan Zhou et al.
Epidermal growth factor receptor (EGFR) plays critical roles in cell proliferation and tumorigenesis. Autophagy has emerged as a potential mechanism involved in the acquired resistance to anti-EGFR treatments, however, the molecular mechani...
Multi-color RNA imaging with CRISPR-Cas13b systems in living cells [0.03%]
活细胞中使用CRISPR-Cas13b系统进行多色RNA成像
Liang-Zhong Yang,Bao-Qing Gao,Youkui Huang et al.
Liang-Zhong Yang et al.
Visualizing RNA dynamics is important for understanding RNA function. Catalytically dead (d) CRISPR-Cas13 systems have been established to image and track RNAs in living cells, but efficient dCas13 for RNA imaging is still limited. Here, we...