Screening of SARS-CoV-2 antivirals through a cell-based RNA-dependent RNA polymerase (RdRp) reporter assay [0.03%]
基于细胞的RNA依赖性RNA聚合酶(RdRp)报告基因测定筛选SARS-CoV-2抗病毒药物
Timsy Uppal,Kai Tuffo,Svetlana Khaiboullina et al.
Timsy Uppal et al.
COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2) continues to pose an international public health threat and thus far, has resulted in greater than 6.4 million deaths worldwide. Vacc...
USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network [0.03%]
USP2通过抑制髓系细胞增殖和重塑细胞外基质网络促进实验性结肠炎和细菌感染
Ran An,Peng Wang,Hao Guo et al.
Ran An et al.
Inflammatory bowel disease (IBD) is closely associated with dysregulation of genetic factors and microbial environment. Here, we report a susceptible role of ubiquitin-specific protease 2 (USP2) in experimental colitis and bacterial infecti...
Human adenoviruses: A suspect behind the outbreak of acute hepatitis in children amid the COVID-19 pandemic [0.03%]
人腺病毒可能是急性肝炎儿童病例激增的罪魁祸首
Hongyun Wang,Shimin Yang,Jiejie Liu et al.
Hongyun Wang et al.
As of 10 May 2022, at least 450 cases of pediatric patients with acute hepatitis of unknown cause have been reported worldwide. Human adenoviruses (HAdVs) have been detected in at least 74 cases, including the F type HAdV41 in 18 cases, whi...
Signaling and functions of interleukin-33 in immune regulation and diseases [0.03%]
细胞因子白介素33在免疫调节和疾病中的信号转导及功能
Xue-Mei Yi,Huan Lian,Shu Li
Xue-Mei Yi
Interleukin-33 (IL-33) which belongs to the interleukin-1 (IL-1) family is an alarmin cytokine with critical roles in tissue homeostasis, pathogenic infection, inflammation, allergy and type 2 immunity. IL-33 transmits signals through its r...
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity [0.03%]
STYK1 磷酸化抑制EGFR对自噬诱导和表皮生长因子受体酪氨酸激酶抑制剂敏感性的作用
Cefan Zhou,Xueying Dong,Ming Wang et al.
Cefan Zhou et al.
Epidermal growth factor receptor (EGFR) plays critical roles in cell proliferation and tumorigenesis. Autophagy has emerged as a potential mechanism involved in the acquired resistance to anti-EGFR treatments, however, the molecular mechani...
Multi-color RNA imaging with CRISPR-Cas13b systems in living cells [0.03%]
活细胞中使用CRISPR-Cas13b系统进行多色RNA成像
Liang-Zhong Yang,Bao-Qing Gao,Youkui Huang et al.
Liang-Zhong Yang et al.
Visualizing RNA dynamics is important for understanding RNA function. Catalytically dead (d) CRISPR-Cas13 systems have been established to image and track RNAs in living cells, but efficient dCas13 for RNA imaging is still limited. Here, we...