Revisiting and corrections to the annotated SRSF3 (SRp20) gene structure and RefSeq sequences from the human and mouse genomes [0.03%]
关于人类和小鼠基因组中SRSF3（SRp20）基因结构注释及RefSeq序列的重新审视与更正
Lulu Yu,Vladimir Majerciak,Rong Jia et al.
Lulu Yu et al.
SRSF3 (SRp20) is the smallest member of the serine/arginine (SR)-rich protein family. We found the annotated human SRSF3 and mouse Srsf3 RefSeq sequences are much larger than the detected SRSF3/Srsf3 RNA size by Northern blot. Mapping of RN...
Inhibition of TRPP3 by calmodulin through Ca2+/calmodulin-dependent protein kinase II [0.03%]
通过钙调神经磷酸酶介导的Ca2+/钙调蛋白依赖性蛋白激酶II抑制TRPP3频道功能
Xiong Liu,Yifang Wang,Ziyi Weng et al.
Xiong Liu et al.
Transient receptor potential (TRP) polycystin-3 (TRPP3) is a non-selective cation channel activated by Ca2+ and protons and is involved in regulating ciliary Ca2+ concentration, hedgehog signaling and sour tasting. The TRPP3 channel functio...
Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins [0.03%]
流感病毒A型病毒蛋白与宿主细胞蛋白互作研究进展
Li Jiang,Hualan Chen,Chengjun Li
Li Jiang
Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In th...
Discovery of oseltamivir-based novel PROTACs as degraders targeting neuraminidase to combat H1N1 influenza virus [0.03%]
基于奥司他韦的新型PROTAC降解剂靶向神经氨酸酶以对抗甲型流感病毒
Zhichao Xu,Xinjin Liu,Xiaoyu Ma et al.
Zhichao Xu et al.
Annual and sporadic influenza outbreaks pose a great threat to human health and the economy worldwide. Moreover, the frequent mutation of influenza viruses caused by antigen drift complicates the application of antiviral therapeutics. As su...
Di Chen,Yan G Zhao,Hong Zhang
Di Chen
During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the viral proteins intimately interact with host factors to remodel the endomembrane system at various steps of the viral lifecycle. The entry of SARS-CoV-2 can ...
Zunpeng Liu,Juan Carlos Izpisua Belmonte,Weiqi Zhang et al.
Zunpeng Liu et al.
Aging is characterized by progressive functional declines at the organismal, organic, and cellular levels and increased susceptibility to aging-related diseases. Epigenetic alteration is a hallmark of aging, senescent cells show epigenomic ...
Yu Chen,Qianyun Liu,Li Zhou et al.
Yu Chen et al.
The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human society. More than 30 mutations in the Spike protein of the Omicron variant severely compromised the protective immunity elicited by either vaccination or prio...
Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription [0.03%]
α7乙酰胆碱受体活化促进HIV-1转录
Jing Wen,Caiqi Zhao,Jie Chen et al.
Jing Wen et al.
Alpha7 nicotinic acetylcholine receptor (α7 nAChR), a hub of the cholinergic anti-inflammatory pathway (CAP), is required for the treatment of inflammatory diseases. HIV-1 infection can upregulate the expression of α7 nAChR in T lymphocyt...
Early and late genome-wide gastric epithelial transcriptome response during infection with the human carcinogen Helicobacterpylori [0.03%]
胃上皮细胞转录组在人致癌菌幽门螺旋杆菌感染早期和晚期的响应规律分析
Irshad Sharafutdinov,Arif Ekici,Michael Vieth et al.
Irshad Sharafutdinov et al.
Infection of the stomach by Helicobacter pylori is a major risk factor for the development of gastric cancer. Colonization of the gastric epithelium leads to the activation of multiple disease-related signaling pathways. Serine protease Htr...
Inhibition of histone methyltransferase SETD8 represses DNA virus replication [0.03%]
组蛋白甲基转移酶SETD8的抑制可抑制DNA病毒复制
Lin Chen,Chen Yang,Shan-Bo Tang et al.
Lin Chen et al.
Multiple diseases, such as cancer and neural degeneration diseases, are related with the latent infection of DNA viruses. However, it is still difficult to clean up the latent DNA viruses and new anti-viral strategies are critical for disea...