Mengxin Liu,Jie Liu,Tong Zhang et al.
Mengxin Liu et al.
Limited regenerative capacity of adult cardiomyocytes precludes heart repair and regeneration after cardiac injury. Direct cardiac reprograming that converts scar-forming cardiac fibroblasts (CFs) into functional induced-cardiomyocytes (iCM...
Identification of a novel binding inhibitor that blocks the interaction between hSCARB2 and VP1 of enterovirus 71 [0.03%]
一种新型结合抑制剂可阻断hSCARB2与肠病毒71型VP1之间相互作用
Qi Tang,Zhichao Xu,Fan Zhang et al.
Qi Tang et al.
Enterovirus 71 (EV-A71) infection causes severe hand-foot-and-mouth disease that leads to cardiopulmonary complications and death in young children under 5 years of age. Although there are available vaccines for EV-A71 C4, however, there ar...
Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity [0.03%]
单纯疱疹病毒蛋白UL56通过抑制cGAS介导的DNA识别来逃逸抗病毒免疫反应
Zhou-Qin Zheng,Yu-Zhi Fu,Su-Yun Wang et al.
Zhou-Qin Zheng et al.
After herpes simplex virus type 1 (HSV-1) infection, the cytosolic sensor cyclic GMP-AMP synthase (cGAS) recognizes DNA and catalyzes synthesis of the second messenger 2'3'-cGAMP. cGAMP binds to the ER-localized adaptor protein MITA (also k...
Ying Cao,Yi Wang,Jing Yang
Ying Cao
Pathological axon degeneration is broadly observed in neurodegenerative diseases. This unique process of axonal pathology could directly interfere with the normal functions of neurocircuitries and contribute to the onset of clinical symptom...
Zilai Wang,Jiyeon Kim,Pin Zhang et al.
Zilai Wang et al.
In the past decades, great progress has been made for the prevention and treatment of lung cancer. Yet, lung cancer remains as the leading cause of cancer death worldwide. In this manuscript, we describe the current genetic and molecular ch...
Free zinc determines the formability of the vesicular dense core in diabetic beta cells [0.03%]
自由锌决定糖尿病β细胞囊泡致密核心的形成性
Yi Xian,Mengxuan Zhou,Yuanzhao Hu et al.
Yi Xian et al.
During the progression of type 2 diabetes, total body zinc deficiency disrupts the formability of the electron-dense core in beta-cell vesicles, but the mechanism is unclear. Using fluorescence imaging, transmission electron microscopy and ...
Zhifei Li,Miaomiao Zheng,Zhicheng He et al.
Zhifei Li et al.
Eukaryotic viruses are obligate intracellular parasites that rely on the host cell machinery to carry out their replication cycle. This complex process involves a series of steps, starting with virus entry, followed by genome replication, a...
The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection [0.03%]
泛素特异性蛋白酶OTUD4通过抑制潘氏细胞抗菌肽的分泌促进肠道炎症和细菌感染
Keying Yu,Yu-Yao Guo,Tianzi Liuyu et al.
Keying Yu et al.
Dysfunction of the intestinal epithelial barrier causes microbial invasion that would lead to inflammation in the gut. Antimicrobial peptides (AMPs) are essential components of the intestinal epithelial barrier, while the regulatory mechani...
Hong-Xia Zhang,Caixiang Zhang,Shuhan Lu et al.
Hong-Xia Zhang et al.
CRISPR-Cas12a based one-pot detection system has been used in nucleic acid detection and diagnosis. However, it is not sensitive enough to distinguish single nucleotide polymorphisms (SNP), which has greatly restricted its application. To o...
Xingxing Shao,Xin Liu,Hai Qi
Xingxing Shao
Germinal center is a transient lymphoid tissue structure in which B cells undergo affinity maturation and differentiate into memory B cells and plasma cells. GC formation depends on B cell expression of BCL6, a master transcription regulato...