Jessica Snyder,Zhihao Wu
Jessica Snyder
Ferroptosis is a newly defined form of programmed cell death. It possesses unique processes of cell demise, cytopathological changes, and independent signal regulation pathways. Ferroptosis is considered to be deeply involved in the develop...
The CHCHD2/Sirt1 corepressors involve in G9a-mediated regulation of RNase H1 expression to control R-loop [0.03%]
CHCHD2/Sirt1 去激活子通过G9a介导的RNase H1表达调控控制R-环形成
Le Li,Yequn Wu,Kui Dai et al.
Le Li et al.
R-loops are regulators of many cellular processes and are threats to genome integrity. Therefore, understanding the mechanisms underlying the regulation of R-loops is important. Inspired by the findings on RNase H1-mediated R-loop degradati...
Combatting persister cells: The daunting task in post-antibiotics era [0.03%]
应对耐药菌的休眠态细胞：后抗生素时代艰巨的任务
Yidan Zhou,Hebin Liao,Linsen Pei et al.
Yidan Zhou et al.
Over the years, much attention has been drawn to antibiotic resistance bacteria, but drug inefficacy caused by a subgroup of special phenotypic variants - persisters - has been largely neglected in both scientific and clinical field. Intere...
Trim25 restricts rabies virus replication by destabilizing phosphoprotein [0.03%]
Trim25通过降解病毒磷蛋白限制狂犬病毒复制
Yueming Yuan,An Fang,Zongmei Wang et al.
Yueming Yuan et al.
Tripartite motif-containing protein 25 (Trim25) is an E3 ubiquitin ligase that activates retinoid acid-inducible gene I (RIG-I) and promotes the antiviral interferon response. Recent studies have shown that Trim25 can bind and degrade viral...
mRNA produced by VSW-3 RNAP has high-level translation efficiency with low inflammatory stimulation [0.03%]
低炎症刺激下VSW-3 RNAP生成的mRNA具有高翻译效率
Guoquan Wang,Rui Cheng,Qiubing Chen et al.
Guoquan Wang et al.
In vitro preparation of mRNA is a key step for mRNA therapeutics. The widely used T7 RNA polymerase (RNAP) was shown to have many by-products during in vitro transcription (IVT) process, among which double-stranded RNA (dsRNA) is the major ...
Ting Li
Ting Li
T cells are involved in many aspects of adaptive immunity, including autoimmunity, anti-tumor activity, and responses to allergenic substances and pathogens. T cells undergo comprehensive epigenome remodeling in response to signals. Polycom...
Endothelial RGS12 governs angiogenesis in inflammatory arthritis by controlling cilia formation and elongation via MYCBP2 signaling [0.03%]
内皮细胞RGS12通过MYCBP2信号传导调控纤毛形成和伸长，在炎性关节炎血管生成中的作用
Gongsheng Yuan,Shu-Ting Yang,Shuying Yang
Gongsheng Yuan
Angiogenesis is the formation of new capillaries that plays an essential role in the pathogenesis of inflammatory arthritis. However, the cellular and molecular mechanisms remain unclear. Here, we provide the first evidence that regulator o...
Hao Zhang,Chengsan Wang,Keyi Zhang et al.
Hao Zhang et al.
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is...
Hou-Yuan Qiu,Rui-Jin Ji,Ying Zhang
Hou-Yuan Qiu
CRISPR-Cas is a versatile genome editing technology that has been broadly applied in both basic research and translation medicine. Ever since its discovery, the bacterial derived endonucleases have been engineered to a collection of robust ...
A selective degeneration of cholinergic neurons mediated by NRADD in an Alzheimer's disease mouse model [0.03%]
在阿尔茨海默病小鼠模型中由NRADD介导的胆碱能神经元选择性退变
Lanfang Li,Bing Zhang,Xiaomei Tang et al.
Lanfang Li et al.
Cholinergic neurons in the basal forebrain constitute a major source of cholinergic inputs to the forebrain, modulate diverse functions including sensory processing, memory and attention, and are vulnerable to Alzheimer's disease (AD). Rece...