An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy [0.03%]
MITA/STING_gain_of_function突变体中的附加位点突变消除了自身免疫SAVI表型并指导了治疗策略
Fang-Xu Li,Sheng Liu,Zhi-Dong Zhang et al.
Fang-Xu Li et al.
STING-associated vasculopathy with onset in infancy (SAVI) is an autoimmune disease caused by gain-of-function mutations (GOFs) of MITA/STING and the most frequent GOFs for SAVI are MITAN154S and MITAV155M. However, how MITA GOFs are sponta...
Host-pathogen interactions in African swine fever: From viral entry to systemic disease progression [0.03%]
非洲猪瘟的宿主病原体互作：从病毒入侵到全身性发病进展
Danyang Zhang,Shilei Zhang,Fayu Yang et al.
Danyang Zhang et al.
African swine fever virus (ASFV), a large and complex double-stranded DNA virus, is the etiological agent of African swine fever (ASF). ASF is a highly contagious and lethal hemorrhagic disease in domestic swine, which poses a persistent th...
Corrigendum to "The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption." [Cell Insight 4 (2025) 100240] [0.03%]
关于“瞬时受体电位通道V4在急性睡眠剥夺引起的记忆障碍中的作用：钙调节紊乱和突触可塑性破坏的机制”的勘误[(细胞洞察力 4 (2025) 100240)]
Meimei Guo,Feiyang Zhang,Sha Liu et al.
Meimei Guo et al.
[This corrects the article DOI: 10.1016/j.cellin.2025.100240.]. © 2025 The Author(s).
Published Erratum
Cell insight. 2025 Dec 24;5(1):100296. DOI:10.1016/j.cellin.2025.100296 2025
Hydrophobic tagging: A promising paradigm for targeted protein degradation [0.03%]
疏水标记：一种前景广阔的靶向蛋白质降解范式
Lilan Xin,Hongli Wang,Maoze Yang et al.
Lilan Xin et al.
Targeted protein degradation (TPD) has emerged as a groundbreaking therapeutic strategy, overcoming the limitations of traditional occupancy-driven pharmacology. Among TPD strategies, hydrophobic tag (HyT) technology exemplifies this paradi...
HTATSF1 regulates innate antiviral immune response by orchestrating TRAF3-IRF3 and TRAF6-NF-κB pathways [0.03%]
HTATSF1通过调控TRAF3-IRF3和TRAF6-NF-κB通路调节先天性抗病毒免疫应答
Jia-Qing Zeng,Zi-Lun Ruan,Qi Zhang et al.
Jia-Qing Zeng et al.
Upon infection, viral DNA/RNA is detected by cGAS/RIG-I-like receptors, triggering the adaptor MITA/STING- or VISA/MAVS-dependent innate antiviral immune response respectively. Both adaptors recruit the conserved TRAF3 and TRAF6 to activate...
CXCL4 and CXCL4L1 activate human macrophage via TLR4 signaling to modulate inflammatory responses [0.03%]
CXCL4和CXCL4L1通过TLR4信号激活人类巨噬细胞以调节炎症反应
Han Bai,Ruoxi Yuan,Dong Yan et al.
Han Bai et al.
The chemokine CXCL4 activates human monocytes/macrophages and contributes to the pathogenesis of inflammatory and fibrotic diseases. However, the receptor of CXCL4, CXCR3, is not expressed in human monocytes/macrophages. Thus, signaling pat...
Development of a comparative high-throughput screening platform for identifying glioblastoma subtype specific inhibitors [0.03%]
一种比较型高通量筛选平台的开发用于鉴定胶质母细胞瘤亚群特异性抑制剂
Zilai Wang,Pin Zhang,Kiira M Ratia et al.
Zilai Wang et al.
Glioblastoma (GBM) is the most lethal primary malignant brain tumor in adults, with the development of effective therapeutic agents largely hampered by vast tumor heterogeneity and the impedance of efficient drug delivery by the blood-brain...
Loop engineering of AtCas9 for effective and broad genome editing [0.03%]
用于有效且广泛基因组编辑的AtCas9蛋白的环路改造工程
Yue-Lin Zhang,Dong-Chao Huang,Min Duan et al.
Yue-Lin Zhang et al.
Efficient genome editing in mammalian cells is essential for CRISPR-based therapeutics. While extensive efforts focused on combining multiple beneficial point mutations to enhance Cas9 activity, the potential of engineering surface-exposed ...
Jianglong Yu,Yuanchun Luo,Jiacheng Lin et al.
Jianglong Yu et al.
Mitochondrial cristae are the principal sites of oxidative phosphorylation and are central to mitochondria-dependent energy metabolism. Rather than static folds, cristae are dynamic bioenergetic compartments that remodel in response to phys...
Hypoxia-induced MT2A-tetrameric PKM2 interaction maintains PKM2 activity in a copper-ion-dependent manner [0.03%]
缺氧诱导的MT2A四聚体PKM2相互作用以铜离子依赖性方式维持PKM2活性
Ronghui Gao,Qifang Li,Jiahao Guo et al.
Ronghui Gao et al.
Hypoxia is a hallmark of solid tumors associated with tumor malignancy. Mitochondrial metabolic reprogramming is a key step in the process of cellular adaptation to hypoxic stress for tumor growth, but the regulatory mechanisms are not full...