Sexual dimorphism in the colonic microbiome and host's transcriptomics profiles of a murine model of multiple sclerosis [0.03%]
William J Doyle,Sean M Schumacher,Megan R Gates et al.
William J Doyle et al.
Background: Multiple Sclerosis is a chronic autoimmune disease that attacks the myelin sheath in the central nervous system, with a higher prevalence among female patients. We and others have documented significant change...
Association between sex hormones and innate cytotoxic capacity of circulating and rectal mucosal immune cells [0.03%]
性激素与循环和直肠粘膜固有免疫细胞先天细胞毒性的相关性分析
Sarah Jung,Mengyu He,Phillip M Murray et al.
Sarah Jung et al.
Sex hormones contribute to sexually dimorphic immunological outcomes, including the innate cytotoxic capacity of Natural Killer (NK) cells in populations of cisgender individuals, but has yet to be evaluated in transgender individuals. Here...
Persistent hypogammaglobulinemia after rituximab therapy in pediatric patients, prevalence and clinical outcomes [0.03%]
利妥昔单抗治疗后儿科患者持续低丙种球蛋白血症的发病率和临床结局
Susanna P C Höppener,Saskia R Veldkamp,Mark C H de Groot et al.
Susanna P C Höppener et al.
Hypogammaglobulinemia is a known side effect of rituximab (RTX) in adults, but its prevalence and persistence in children remain underexplored. This retrospective cohort study at a tertiary care center examines the prevalence and clinical o...
Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis [0.03%]
未经治疗的青少年皮肌炎中HLA-DR T细胞比例升高
Amer Khojah,Madeline Schutt,Gabrielle Morgan et al.
Amer Khojah et al.
This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cel...
Altered pre-existing SARS-CoV-2-specific T cell responses in elderly individuals [0.03%]
老年人的SARS-CoV-2特异性T细胞反应改变
Naoyuki Taira,Sakura Toguchi,Mio Miyagi et al.
Naoyuki Taira et al.
Pre-existing SARS-CoV-2-specific T cells, but not antibodies, have been detected in some unexposed individuals. This may account for some of the diversity in clinical outcomes ranging from asymptomatic infection to severe COVID-19. Although...
Prevalence of asymptomatic SARS-CoV-2 infection in an Austrian cohort [0.03%]
奥地利队列中无症状SARS-CoV-2感染的流行率
Elisabeth Mara,Verena Breitsching,Tanja Schuster et al.
Elisabeth Mara et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged at the end of 2019, causing the coronavirus disease (COVID-19). The main sources of infections are infected and asymptomatic persons. One major problem of the pandem...
Pharmacokinetics of convalescent plasma therapy in a COVID-19 patient with X-linked Agammaglobulinemia [0.03%]
X连锁低丙种球蛋白血症COVID-19患者恢复期血浆治疗的药代动力学特征分析
Jennifer L Yates,David S Palat,M Kristina Subik et al.
Jennifer L Yates et al.
Convalescent plasma (CP) has been the first line of defense against numerous infectious diseases throughout history. The COVID-19 pandemic created a need for a quick, easily accessible, and effective treatment for severe disease and CP was ...
COVID-19 in a patient with Good's syndrome and in 13 patients with common variable immunodeficiency [0.03%]
戈德综合征和13例常见变量免疫缺陷患者的COVID-19感染
Hannes Lindahl,C I Edvard Smith,Peter Bergman
Hannes Lindahl
Antibody deficiencies constitute the majority of primary immunodeficiencies in adults. These patients have a well-established increased risk of bacterial infections but there is a lack of knowledge regarding the relative risks upon contract...
Alexandre Landry,Stéphanie Crapoulet,Luc H Boudreau et al.
Alexandre Landry et al.
We present a rare case of meningoradiculitis occurring after mRNA COVID-19 vaccination. This patient, with a history of inflammatory arthritis following rubella vaccination, presented to the emergency department 4 days after her vaccination...
The "original antigenic sin" and its relevance for SARS-CoV-2 (COVID-19) vaccination [0.03%]
“原抗原则”及其对SARS-CoV-2（COVID-19）疫苗接种的相关性
Ger T Rijkers,Frans J van Overveld
Ger T Rijkers
Imprinting of the specific molecular image of a given protein antigen into immunological memory is one of the hallmarks of immunity. A later contact with a related, but different antigen should not trigger the memory response (because the p...