Contouring and dose extraction of the maxilla, mandible and teeth on head and neck cancer radiotherapy planning scans [0.03%]
头颈部肿瘤放射治疗计划扫描中的上颌骨、下颌骨和牙齿的轮廓及剂量提取
Emma C Foster-Thomas,Koen B Krommenhoek,Shermaine Pan et al.
Emma C Foster-Thomas et al.
Background and purpose: Despite their vulnerability to radiation-induced damage, the maxilla and dentition are not routinely contoured in head and neck (HN) radiotherapy (RT), preventing accurate dose assessment and estab...
From the bench of molecular understanding to the bedside of optimal therapy for BCR:: ABL1 and ABL-class acute lymphoblastic leukemia in children and adolescents [0.03%]
从分子水平认识出发，优化儿童和青少年BCR-ABL1和其他ABL类急性淋巴细胞白血病治疗策略
Sarah K Tasian,Judith M Boer,Monique L den Boer
Sarah K Tasian
This review aims to discuss similarities and dissimilarities between BCR::ABL1-rearranged (Philadelphia chromosome-positive [Ph+]) and ABL-class fusion-driven BCR::ABL1-like (Ph-like) acute lymphoblastic leukemia (ALL) in children and adole...
Childhood cancer survival in low- and middle-income countries and the Global South: emerging evidence and critical gaps from a scoping review of observational studies [0.03%]
中低收入国家和全球南方儿童癌症生存现状：观察性研究的系统评价证据及关键缺口
Marilina Santero,Roberta Ortiz Sequeira,Margarida Cruz Paixao et al.
Marilina Santero et al.
Background: Survival rates for childhood cancer reveal stark global disparities. While over 80 % of children survive in high-income countries (HICs), outcomes remain significantly lower in low- and middle-income countries...
The path towards a population-based childhood cancer registry in the region of Dakar in Senegal: A feasibility study of the Franco-African Paediatric Oncology Group (GFAOP) [0.03%]
塞内加尔达喀尔地区基于人口的儿童癌症登记处建设之路：一项Franco-African儿科肿瘤学小组（GFAOP）可行性研究
Brenda Mallon,Chérif Dial,Fatou Binetou Akonde et al.
Brenda Mallon et al.
Introduction and background: The Global Initiative for Childhood Cancer of the World Health Organisation emphasise the importance of registration, especially in low-and middle-income countries, where data are sparse. The ...
Adam D Durbin,Rogier Versteeg
Adam D Durbin
Evolving evidence indicates that tumor cells can transdifferentiate between distinct transcriptionally-determined cell states with changes in resultant phenotypes, a phenomenon known as cellular plasticity. These transitions are not driven ...
Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma [0.03%]
眼球摘除作为视网膜母细胞瘤诊断治疗方法的儿童辅助治疗研究
Yelena Diarra,Christina Brockmeyer,Karen Fischhuber et al.
Yelena Diarra et al.
Introduction: Advanced localized retinoblastoma can be cured by enucleation, but extraocular spread of retinoblastoma cells is associated with a high mortality. Risk-stratified adjuvant treatment with chemotherapy and rad...
Response to induction chemotherapy modifies the effect of conventional prognostic factors in high-risk neuroblastoma: A report from the Children's Oncology Group [0.03%]
诱导化疗的反应会修改高危神经母细胞瘤传统预后因素的影响：儿童肿瘤学组报告
Elizabeth Sokol,Brian LaBarre,Navin Pinto et al.
Elizabeth Sokol et al.
Background: Response to induction chemotherapy has been shown to predict outcome in patients with high-risk neuroblastoma (HR-NB), with those achieving a complete response (CR) having superior outcomes. ...
Environmental risk factors of Wilms tumour: A systematic review and meta-analysis [0.03%]
儿童肾母细胞瘤的环境危险因素：系统评价和荟萃分析
Felix M Onyije,Roya Dolatkhah,Ann Olsson et al.
Felix M Onyije et al.
Wilms tumour (WT) is the fourth leading cause of cancer death in children. Elucidating modifiable risk factors is crucial in identifying venues for primary prevention of the disease. This study aimed to review literature and synthesize envi...
The neuroblastoma tumor microenvironment: From an in-depth characterization towards novel therapies [0.03%]
神经母细胞瘤肿瘤微环境：从深入表征到新型疗法
Kevin Louault,Yves A De Clerck,Isabelle Janoueix-Lerosey
Kevin Louault
Neuroblastoma is a cancer of the sympathetic nervous system that develops in young children, either as low-risk or high-risk disease. The tumor microenvironment (TME) is now recognized as an important player of the tumor ecosystem that may ...
CAR T cells redirected to B7-H3 for pediatric solid tumors: Current status and future perspectives [0.03%]
针对儿童实体瘤的B7-H3重定向的CAR-T细胞：现状及未来展望
Rebecca Epperly,Stephen Gottschalk,Christopher DeRenzo
Rebecca Epperly
Despite intensive therapies, pediatric patients with relapsed or refractory solid tumors have poor outcomes and need novel treatments. Immune therapies offer an alternative to conventional treatment options but require the identification of...