Pathogenesis, pathological characteristics and individualized therapy for immune-related adverse effects [0.03%]
免疫相关不良事件的发病机制、病理特征及个体化处理策略研究进展
Kang Miao,Li Zhang
Kang Miao
Immune checkpoint inhibitors (ICIs) are a class of antitumor medications that target immune checkpoints, which induce the activation of lymphocytes. These treatments effectively prolong the survival of patients with advanced tumors, especia...
Wenqian Wu,Zhiwei Li,Yongqiang Wang et al.
Wenqian Wu et al.
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with limited airflow. COPD is characterized by chronic bronchitis and emphysema, and is often accompanied by malnutrition with fatigue, muscle weakness, and an increased...
Novel tools for early diagnosis and precision treatment based on artificial intelligence [0.03%]
基于人工智能的早期诊断和精准治疗新技术
Jun Shao,Jiaming Feng,Jingwei Li et al.
Jun Shao et al.
Lung cancer has the highest mortality rate among all cancers in the world. Hence, early diagnosis and personalized treatment plans are crucial to improving its 5-year survival rate. Chest computed tomography (CT) serves as an essential tool...
Exploring the microbiome: Uncovering the link with lung cancer and implications for diagnosis and treatment [0.03%]
探究微生物组：揭示其与肺癌的关联及对诊断和治疗的意义
Junqi Yi,Juanjuan Xiang,Jingqun Tang
Junqi Yi
Lung cancer is the leading cause of cancer-related deaths worldwide. Tobacco smoking and air pollution are believed to be responsible for more than 90% of lung cancers. Respiratory pathogens are also known to be associated with the initiati...
From gene identifications to therapeutic targets for asthma: Focus on great potentials of TSLP, ORMDL3, and GSDMB [0.03%]
从哮喘的基因鉴定到治疗靶点：关注TSLP、ORMDL3和GSDMB的巨大潜力
Youming Zhang
Youming Zhang
Asthma is a chronic respiratory disease, and clinically, asthma exacerbations remain difficult to treat. The disease is caused by combinations of and interactions between genetic and environmental factors. Genomic and genetic approaches ide...
Changing profile of lung cancer clinical characteristics in China: Over 8-year population-based study [0.03%]
基于人群的八年随访研究揭示我国肺癌临床特征的变化趋势
Kandi Xu,Hao Wang,Simin Li et al.
Kandi Xu et al.
Background: Although examinations and therapies for bronchial lung cancer, also called lung cancer (LC), have become more effective and precise, the morbidity and mortality of LC remain high worldwide. Describing the chan...
Dimitrios Toumpanakis,Omar S Usmani
Dimitrios Toumpanakis
Background: The aim of this review is to summarize the current evidence regarding small airway disease in asthma, focusing on recent advances in small airway pathophysiology, assessment and therapeutic implications. ...
Liver dysfunction on admission worsens clinical manifestations and outcomes of coronavirus disease 2019 [0.03%]
入院时肝功能异常恶化新型冠状病毒肺炎临床表现和预后
Fangying Lu,Rong Chen,Kandi Xu et al.
Fangying Lu et al.
Background: Liver dysfunction was common in coronavirus disease 2019 (COVID-19), but its association with clinical features and poor prognosis has not been fully delineated. Our study aimed to determine the role of liver ...
Light at night and lung cancer risk: A worldwide interdisciplinary and time-series study [0.03%]
夜间光照与肺癌风险的全球性跨学科和时间序列研究
Runchen Wang,Qixia Wang,Jianfu Li et al.
Runchen Wang et al.
Background: Light at night (LAN) has become a concern in interdisciplinary research in recent years. This global interdisciplinary study aimed to explore the exposure-lag-response association between LAN exposure and lung...
Molin Yue,Shiyue Tao,Kristina Gaietto et al.
Molin Yue et al.
Asthma, a chronic respiratory disease with a global prevalence of approximately 300 million individuals, presents a significant societal and economic burden. This multifaceted syndrome exhibits diverse clinical phenotypes and pathogenic end...