Circadian rhythms and lung cancer biology and immunotherapy: Emerging opportunities and challenges [0.03%]
昼夜节律与肺癌生物学和免疫治疗：新机遇与挑战
Fang Tian,Songkai Wang,Zhe Huang et al.
Fang Tian et al.
The circadian rhythm is an intrinsic timekeeping system that precisely regulates a wide range of physiological and pathological processes. Its core molecular mechanisms and regulatory networks are gaining increasing attention in the field o...
Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk [0.03%]
肺癌与神经相互作用的分子机制和治疗靶点
Ziyang Xu,Shanshan Huang,Qian Chu
Ziyang Xu
Reciprocal crosstalk between the nervous system and malignancies is increasingly recognized as a key regulator of tumor progression across solid cancers. Neuronal activity and nerve infiltration can shape tumor growth, immune tone, and meta...
Zheqing Hu,Liyuan Yang,Yabo Ma et al.
Zheqing Hu et al.
Intractable mucus plugging drives mortality in cystic fibrosis (CF), asthma, and chronic obstructive pulmonary disease (COPD). While surface metaplasia narrows small airways, the massive volumetric reservoir capacity of hypertrophied submuc...
Respiratory microbiota transplantation: optimized framework and its impact on metabolic and immune characteristics [0.03%]
呼吸道微生态系统移植及其对代谢和免疫特性的影响
Shifen Xu,Xing Zhang,Yunfeng Shi et al.
Shifen Xu et al.
Background: The respiratory microbiota is critical to maintaining local immune homeostasis and respiratory health. Microbiota transplantation has proven transformative in gut microbiome studies. However, a standardized ap...
From "shooting in the dark" to "precision hit": Technological evolution, synergistic strategies, and future paths for peripheral pulmonary nodule diagnosis [0.03%]
从“盲人摸象”到“精准打击”:外周型肺结节诊断的技术演进、协同策略和未来之路
Ximing Liao,Qiang Li,Ko-Pen Wang
Ximing Liao
Artificial intelligence in respiratory medicine: From diagnosis to treatment and future directions [0.03%]
呼吸医学中的人工智能：从诊断到治疗和未来方向
Zhe Chen,Zhiyong Tang,Rob M Ewing et al.
Zhe Chen et al.
Lung diseases-including lung cancer, chronic obstructive pulmonary disease (COPD), asthma, interstitial lung diseases (ILDs), and rare conditions like cystic fibrosis-remain major drivers of global morbidity and mortality. Timely diagnosis ...
UBE2M deficiency in alveolar macrophages promotes emphysema through HIF-2α/MMP12 axis [0.03%]
溶酶体介导的UBE2M在肺巨噬细胞中的降解调控肺气肿形成中的作用
Zhouyang Li,Dongyu Guo,Yong Wang et al.
Zhouyang Li et al.
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of global mortality; however, its pathogenesis remains incompletely understood, limiting therapeutic options. Protein neddylation, a key post-tra...
Incidence of acute exacerbation and its related factors among chronic obstructive pulmonary disease patients aged 40 years and older in China [0.03%]
中国40岁及以上慢性阻塞性肺疾病患者急性加重发生率及影响因素调查分析
Qi Luo,Shu Cong,Shige Qi et al.
Qi Luo et al.
Background: Acute exacerbation of chronic obstructive pulmonary disease (COPD) (AECOPD) represents a pivotal event in the clinical course of COPD and contributes substantially to disease progression and healthcare burden....
Trained immunity in respiratory diseases: Mechanisms of action and intervention strategies [0.03%]
训练免疫在呼吸系统疾病中的作用机制和干预策略
Szu-Yu Lee,Jing Li,Xikun Zhou
Szu-Yu Lee
Trained immunity refers to a form of nonspecific immunological memory established through epigenetic modifications and metabolic reprogramming in innate immune cells following stimulation. This concept offers a novel framework for understan...
Nanovaccines for lung cancer: Platforms, mechanistic insights, and translational challenges [0.03%]
肺癌纳米疫苗：平台、机制见解及转化挑战
Hamed Hosseinalizadeh,Fujing Ge,Mohsen Davari et al.
Hamed Hosseinalizadeh et al.
Lung cancer remains a global health challenge, with high mortality rates and frequent resistance to conventional therapies. In recent years, nanovaccines-based immunotherapy has emerged as a promising frontier, harnessing advances in nanote...