Immunotherapy for patients with EGFR-TKI-resistant non-small-cell lung cancer: Potential mechanisms, efficacy predictors, and therapeutic integration [0.03%]
表皮生长因子受体酪氨酸激酶抑制剂耐药的非小细胞肺癌患者的免疫治疗：潜在机制、疗效预测因素和治疗整合策略
Xinwei Wu,Yangbin Shi,Danni Wang et al.
Xinwei Wu et al.
Immunotherapy has revolutionized the treatment landscape of advanced non-small-cell lung cancer (NSCLC). However, its efficacy in patients with epidermal growth factor receptor (EGFR)-mutant NSCLC, particularly after failure of EGFR-tyrosin...
Progression of interstitial lung abnormalities and its impact on mortality in patients with lung cancer resection [0.03%]
肺癌术后患者间质性肺异常的进展及对死亡率的影响
Ruolin Mao,Haoyun Zhang,Qing Chang et al.
Ruolin Mao et al.
Background: Interstitial lung abnormalities (ILAs) are incidental abnormal lung findings on computed tomography that can co-exist with lung cancer, but risk factors for their progression and impact on survival after lung ...
Metabolomic and lipidomic signatures associated with clinical improvement after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension [0.03%]
球囊肺动脉成形术治疗慢性血栓性肺高血压后的代谢组学和脂质组学特征变化研究
Jinglin Tian,Sugang Gong,Ping Yuan et al.
Jinglin Tian et al.
Ioana Agache,Shengjie Li,Yang Zheng et al.
Ioana Agache et al.
The model of asthma as a single entity has now been replaced by a much more complex biological network of distinct and interrelating inflammatory and tissue driven pathways. Individual disease manifestations (phenotypes), pathogenetic pathw...
Type 2 inflammation in chronic obstructive pulmonary disease: A promising treatable trait and practice recommendations [0.03%]
慢性阻塞性肺疾病的2型炎症：一种具有前景的可治疗特征及实践建议
Yan Chen,Ting Yang,Jing Zhang et al.
Yan Chen et al.
Background: Type 2 inflammation is a key inflammatory endotype of chronic obstructive pulmonary disease (COPD). The precise identification and targeted intervention of treatable traits related to type 2 inflammation are c...
Risk factors for severe and prolonged cough in influenza and COVID-19: A post hoc analysis of three randomized controlled trials [0.03%]
三项随机对照试验的事后分析：流感和新冠肺炎严重及长期咳嗽的影响因素
Yang Jin,Qidan Hu,Jingya Li et al.
Yang Jin et al.
Yanan Zhou,Gaoying Chen,Xiang Li et al.
Yanan Zhou et al.
As life expectancy increases globally, the prevalence of various age-related diseases among the elderly is rising. Advancing age is associated with both the incidence and mortality of a variety of respiratory diseases; however, the specific...
Enrichment of the commensal microbiome in the lower respiratory tract is associated with improved outcomes following lung transplantation [0.03%]
移植物定植的共生微生物组与肺移植后的改善结局相关
Chun Wang,Kang Chang,Mengyin Chen et al.
Chun Wang et al.
Background: Alterations in the respiratory microbiome are common following lung transplantation; however, the complex relationship between microbial composition and posttransplant clinical outcomes remains insufficiently ...
Hui Han,Yongxian Hu
Hui Han
Chimeric antigen receptor (CAR) T cell (CAR-T) therapy is a form of adoptive immunotherapy based on the genetic engineering of T lymphocytes. The expression of CARs on T cells facilitates precise, efficient immune responses by enabling dire...
Global, regional, and national burden of interstitial lung disease and pulmonary sarcoidosis from 1990 to 2023, and projections to 2050: A systematic analysis for the Global Burden of Disease Study 2023 [0.03%]
1990年到2023年的间质性肺病和肺泡肉芽肿病的全球、区域和国家疾病负担以及2050年预测：2023年全球疾病负担研究系统分析
Xiaoqian Ma,Lili Zhu,Huijuan Xiao et al.
Xiaoqian Ma et al.
Background: Interstitial lung disease (ILD) and pulmonary sarcoidosis are a group of complex respiratory conditions imposing a significant and growing global health burden. A comprehensive, up-to-date assessment of their ...