Association of ratios of visceral fat area/subcutaneous fat area and muscle area/standard body weight at T12 CT level with the prognosis of acute respiratory distress syndrome [0.03%]
腰椎T12水平的腹腔脂肪面积与皮下脂肪面积比值及肌肉面积与标准体重比值与急性呼吸窘迫综合征预后的关联性研究
Hui Shen,Ying He,Fan Lu et al.
Hui Shen et al.
Background: It is well-known that body composition metrics can influence the prognosis of various diseases. This study investigated how body composition metrics predict acute respiratory distress syndrome (ARDS) prognosis...
Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome [0.03%]
急性肺损伤和急性呼吸窘迫综合征中肺内皮屏障功能障碍的机制研究
Yunchao Su,Rudolf Lucas,David J R Fulton et al.
Yunchao Su et al.
Endothelial cells (ECs) form a semi-permeable barrier between the interior space of blood vessels and the underlying tissues. Pulmonary endothelial barrier integrity is maintained through coordinated cellular processes involving receptors, ...
Biomarkers in idiopathic pulmonary fibrosis: Current insight and future direction [0.03%]
特发性肺纤维化中的生物标志物：当前见解和未来方向
Zhen Zheng,Fei Peng,Yong Zhou
Zhen Zheng
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease with a dismal prognosis. Early diagnosis, accurate prognosis, and personalized therapeutic interventions are essential for improving patient outcomes...
Epithelial stem cells and niches in lung alveolar regeneration and diseases [0.03%]
肺泡再生和疾病中的上皮干细胞及其生态位
Jilei Zhang,Yuru Liu
Jilei Zhang
Alveoli serve as the functional units of the lungs, responsible for the critical task of blood-gas exchange. Comprising type I (AT1) and type II (AT2) cells, the alveolar epithelium is continuously subject to external aggressors like pathog...
Emerging role of cellular senescence in normal lung development and perinatal lung injury [0.03%]
细胞衰老在正常肺发育和围产期肺损伤中的作用不容忽视
Phyllis A Dennery,Hongwei Yao
Phyllis A Dennery
Cellular senescence is a status of irreversible growth arrest, which can be triggered by the p53/p21cip1 and p16INK4/Rb pathways via intrinsic and external factors. Senescent cells are typically enlarged and flattened, and characterized by ...
Dysregulated bidirectional epithelial-mesenchymal crosstalk: a core determinant of lung fibrosis progression [0.03%]
失调的双向上皮间质相互作用：肺纤维化进展的核心决定因素
Liudi Yao,Zijian Xu,Donna E Davies et al.
Liudi Yao et al.
Progressive lung fibrosis is characterised by dysregulated extracellular matrix (ECM) homeostasis. Understanding of disease pathogenesis remains limited and has prevented the development of effective treatments. While an abnormal wound heal...
TIMP-1 and its potential diagnostic and prognostic value in pulmonary diseases [0.03%]
TIMP-1及其在肺部疾病诊断和预后判断中的潜在价值
Sultan Almuntashiri,Abdullah Alhumaid,Yin Zhu et al.
Sultan Almuntashiri et al.
Tissue inhibitors of metalloproteases (TIMPs) have caught the attention of many scientists due to their role in various physiological and pathological processes. TIMP-1, 2, 3, and 4 are known members of the TIMPs family. TIMPs exert their b...
Nicholas J Wallbillich,Hua Lu
Nicholas J Wallbillich
Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite the recent advances in cancer therapies, the 5-year survival of non-small cell lung cancer (NSCLC) patients hovers around 20%. Inherent and acquired resistanc...
Taking early preventive interventions to manage the challenging issue of acquired resistance to third-generation EGFR inhibitors [0.03%]
采取早期预防干预措施管理第三代EGFR抑制剂获得性耐药难题
Shi-Yong Sun
Shi-Yong Sun
Although the clinical efficacies of third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) such as osimertinib in the treatment of non-small cell lung cancer (NSCLC) with EGFR-activating mutations are pro...
Pulmonary fibrosis: A short- or long-term sequelae of severe COVID-19? [0.03%]
肺纤维化：重度新冠肺炎的短期或长期后遗症？
Zhen Zheng,Fei Peng,Yong Zhou
Zhen Zheng
The pandemic of coronavirus disease 2019 (COVID‑19), caused by a novel severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), has caused an enormous impact on the global healthcare. SARS-CoV-2 infection primarily targets the ...