Twenty years of changes in the definition of early chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病早期定义的变迁——二十年回顾
Dian Chen,Jeffrey L Curtis,Yahong Chen
Dian Chen
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease that affects the quality of life of nearly one-tenth of the global population. Due to irreversible airflow obstruction and progressive lung function decli...
Wensheng Zhou,Lishu Zhao,Hao Wang et al.
Wensheng Zhou et al.
Pyroptosis is a type of programed cell death that differs from apoptosis, ferroptosis, or necrosis. Numerous studies have reported that it plays a critical role in tumorigenesis and modification of the tumor microenvironment in multiple tum...
Low BMI patients with advanced EGFR mutation-positive NSCLC can get a better outcome from metformin plus EGFR-TKI as first-line therapy: A secondary analysis of a phase 2 randomized clinical trial [0.03%]
一项2期随机临床试验的二次分析：低体质指数伴有表皮生长因子受体突变阳性的晚期非小细胞肺癌患者可以从二甲双胍联合表皮生长因子受体酪氨酸激酶抑制剂的一线治疗中获益更多
Rui Han,Jianghua Li,Yubo Wang et al.
Rui Han et al.
Background: The synergistic association between metformin and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) has been confirmed in in vitro studies. It is still controversial which patients can ...
Emerging roles and therapeutic implications of HDAC2 and IL-17A in steroid-resistant asthma [0.03%]
HDAC2和IL-17A在糖皮质激素抵抗型哮喘中的新兴作用及治疗意义
Lihuan Ouyang,Guomei Su,Jingyun Quan et al.
Lihuan Ouyang et al.
Steroid resistance represents a major clinical problem in the treatment of severe asthma, and therefore a better understanding of its pathogenesis is warranted. Recent studies indicated that histone deacetylase 2 (HDAC2) and interleukin 17A...
Positive sputum culture of Candida spp . as a risk factor for 30-day mortality in patients with hospital-acquired pneumonia: A propensity-score matched retrospective clinical study [0.03%]
医院获得性肺炎患者出院后30天内死亡与白色念珠菌阳性痰培养的关系：倾向匹配病例对照研究
Yaopin Han,Yihui Zuo,Zhe Luo et al.
Yaopin Han et al.
Background: Candida species (Candida spp.) are commonly isolated microorganisms from lower respiratory tract (LRT) specimens of patients with hospital-acquired pneumonia (HAP); however, the clinical significance remains c...
Early detection and prediction of acute exacerbation of chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的急性加重的早期检测与预测
Jing Zhang,Fangman Chen,Yongli Wang et al.
Jing Zhang et al.
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. Acute exacerbation of COPD (AECOPD) is an acute worsening of respiratory symptoms, which needs additional treatment and...
Meiting Yue,Zhen Qin,Liang Hu et al.
Meiting Yue et al.
Cancer cachexia is a multifactorial syndrome characterized by loss of body weight secondary to skeletal muscle atrophy and adipose tissue wasting. It not only has a significant impact on patients' quality of life but also reduces the effect...
Xiaoling Tian,Zhe Liu
Xiaoling Tian
Germline genetic variants, including single-nucleotide variants (SNVs) and copy number variants (CNVs), account for interpatient heterogeneity. In the past several decades, genome-wide association studies (GWAS) have identified multiple lun...
Prevalence of nicotine dependence among smokers aged 40 years and older in China [0.03%]
中国40岁及以上吸烟者尼古丁依赖流行趋势分析
Ying Ji,Shu Cong,Jing Fan et al.
Ying Ji et al.
Background: Nicotine dependence, also known as tobacco dependence, is a common chronic disease and a major risk factor for chronic respiratory diseases. The present study was designed to determine the prevalence of nicoti...
Ting Xie,Jiurong Liang,Barry Stripp et al.
Ting Xie et al.
Cell-cell interactions are essential components of coordinated cell function in lung homeostasis. Lung diseases involve altered cell-cell interactions and communication between different cell types, as well as between subsets of cells of th...