Comprehensive Review of Factors Influencing Intrasubject Variability in Bioequivalence Studies [0.03%]
影响生物等效性研究受试者内变异性的综合评价因素综述
Shrikrishna Bajarang Pawar,Atul N Chandu,Saravanan Devarajan
Shrikrishna Bajarang Pawar
Intrasubject variability (ISV) in bioequivalence (BE) studies remains a critical challenge in generic drug development; however, the mechanistic determinants of this variability are not yet fully characterized. This narrative review synthes...
The Evolution and Impact of Pharmacist-Driven Antimicrobial Stewardship Programs: A Review [0.03%]
基于药师的抗菌药物管理项目的演变和影响综述
Shesham Kumari,Ranjeet Kumar,Manish Singh et al.
Shesham Kumari et al.
Antimicrobial resistance (AMR) continues to increase at an alarming rate worldwide. Antimicrobial Stewardship Programs (ASPs) play a critical role in mitigating the growing threat of AMR. The objective of this review is to summarize the exp...
Toll-Like Receptor-Mediated Neuroinflammation and Its Role in Neurocognitive Functions [0.03%]
toll-like受体介导的神经炎症及其在神经认知功能中的作用
Vivek Srivastava,Suman Chakraborty,Richa Srivastava
Vivek Srivastava
Toll-like receptors (TLRs) are a family of pattern recognition receptors that recognise both pathogen-associated and damage-associated molecular patterns. While their expression was initially believed to be restricted to immune cells, accum...
Microbiome Drug Interactions in Cancer Pharmacology: Mechanisms and Therapeutic Opportunities [0.03%]
癌症药理学中的微生物组药物相互作用：机制和治疗机会
Arvind Kumar Patel,Neha Singh,Phool Chandra et al.
Arvind Kumar Patel et al.
Introduction: Interindividual variability in cancer therapy response cannot be fully explained by host genetics or tumor characteristics alone. Emerging evidence indicates that the gut microbiome is a critical modulator o...
Exploring TRPM7 Channel-Kinase for Disease Modulation: A Translational Approach [0.03%]
TRPM7通道-激酶疾病调制的转化研究方法学探索
Ishita Mitra,Priyanka Chakraborty,Sailee Chowdhury et al.
Ishita Mitra et al.
Introduction: This review examines the multifaceted involvement of the transient receptor potential melastatin-7 (TRPM7) channel-kinase in human disease and evaluates its suitability as a selective therapeutic target. Par...
Model-Informed Precision Dosing in Pediatrics: Current Practices, Opportunities, and Challenges [0.03%]
儿科精准给药的模型依赖性现状、机遇与挑战
Rohith Anandan Prabakar,Abilash Reddybathini,Chandramouli Radhakrishnan et al.
Rohith Anandan Prabakar et al.
Recent advances in pediatric pharmacokinetics highlight substantial age-dependent physiological changes that require specialised approaches to optimise efficacy and minimise adverse effects in children. This review compares pharmacokinetic ...
Pharmacological Perspectives on Curcumin in Osteomyelitis: Molecular Mechanisms, Antibacterial Synergy, and Bone-Regenerative Potential [0.03%]
药理学视角下的姜黄素抗骨髓炎作用：分子机制、协同抗菌活性及促骨再生潜力
Solmaz Maleki Dizaj,Mohammad Yousef Memar,Simin Sharifi et al.
Solmaz Maleki Dizaj et al.
Osteomyelitis is difficult to treat due to biofilm persistence, limited antibiotic penetration, and increasing resistance. Curcumin, a pleiotropic polyphenol from Curcuma longa, shows convergent activity relevant to bone infection: (i) anti...
Role of Lysosomal Genes for Parkinson's Pathogenesis: Insights from Molecular Mechanism to Therapeutic Strategies [0.03%]
溶酶体基因在帕金森病发病机制中的作用：从分子机制到治疗策略的见解
Vidhan Chand Bala,Asheesh Kumar Gupta,Amit Kumar et al.
Vidhan Chand Bala et al.
Current review aims to clarify the role of lysosomal genes in the pathogenesis of Parkinson's Disease (PD), directing on the molecular mechanisms underlying lysosomal dysfunction and its involvement to α-synuclein accumulation. To delibera...
Mechanistic Insights and Therapeutic Potential of MCC950 as a NLRP3 Inflammasome Inhibitor in Multiple Sclerosis: A Narrative Review [0.03%]
MCC950作为NLRP3炎性小体抑制剂在多发性硬化症中的机制见解和治疗潜力：叙述性综述
Fatemeh Rabiei,Hamid Askari,Arshia Vala et al.
Fatemeh Rabiei et al.
Introduction: The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a central driver of neuroinflammation and demyelination in multiple sclerosis (MS). MCC950, a selective small-molecule NLRP3 inhibitor, has em...
Leonid N Maslov,Alexander V Mukhomedzyanov,Alisa S Slidnevskaya et al.
Leonid N Maslov et al.
Almost immediately after the discovery of opioid peptides and opioid receptors (ORs), reports were published that some effects of opioid peptides are independent of the activation of ORs. It was demonstrated that Des-Tyr1-fragments of opioi...