Lu Bai,Yuanyuan Li,Yantong Li et al.
Lu Bai et al.
Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic fungal infection in immunocompromised populations. Microscopic identification of P. jirovecii cysts or trophozoites in lower respiratory specimens remains the diagno...
Caren Challita,Nour El Moussawi,Maya Dagher et al.
Caren Challita et al.
Vulvar tuberculosis is an exceptionally rare manifestation of extrapulmonary Mycobacterium tuberculosis infection. We describe a 28-year-old woman from Republic of the Philippines presenting with a painful vulvar lesion of 3 months' duratio...
Combination of minocycline and ciprofloxacin enhances the inhibitory effect of tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells [0.03%]
二甲双胍通过AMPK-mTOR信号通路抑制脂多糖诱导的小胶质细胞活化和炎症反应
Ippei Sakamaki,Yukie Tanaka,Hiromichi Iwasaki
Ippei Sakamaki
Background: Tetracyclines, such as minocycline (MINO), are widely used in the treatment of infectious diseases. Japanese spotted fever (JSF) is usually treated with MINO. When MINO alone is ineffective in treating severe ...
Beyond monotherapy: Combination therapies for HIV-1 cure through joint application of neutralizing antibodies, genome editing, and reservoir management [0.03%]
超越单药治疗：联合应用中和抗体、基因编辑和潜伏库管理的HIV-1治愈疗法
Qiongbin Mao,Lin Li,Hongling Wen
Qiongbin Mao
Despite its potency in suppressing HIV-1 replication, antiretroviral therapy (ART) cannot eliminate latent viral reservoirs and is associated with several limitations, such as the need for lifelong treatment and the inherent risk of drug re...
National trends in burden of enteric infections in China: Shifts from 1990 to 2021 [0.03%]
中国肠道感染疾病负担的国家趋势（1990年至2021年的转变）
Huichao Wu,Menglong Li,Zuolin Lu et al.
Huichao Wu et al.
Background: Enteric infections impose a substantial global health burden annually, especially in countries with inadequate sanitation. This study aims to assess the trends in the burden of enteric infections in China. ...
The use of tNGS in the diagnosis of Q fever: A case report and review of cases of liver injury [0.03%]
tNGS在Q热诊断中的应用：一起病例报告及肝脏损伤病例的文献复习
Yicheng Peng,Guoyin Fan,Di Jin et al.
Yicheng Peng et al.
This report describes a case of Q fever with predominantly liver injury presentation. We used targeted next generation sequencing (tNGS) and immunologic methods to identify a case of acute stage infection of Q fever with liver injury; promp...
Immune dysregulation in type 2 diabetes mellitus: Implications for tuberculosis, COVID-19, and HIV/AIDS [0.03%]
2型糖尿病患者的免疫功能紊乱与结核病、新冠肺炎和艾滋病的关系
Uzair Abbas,Harendra Kumar,Niaz Hussain et al.
Uzair Abbas et al.
Diabetes mellitus (DM) is a complex and multifactorial disorder associated with elevated blood sugar levels, poor insulin sensitivity, and inadequate insulin production. It has a major impact on the immune system, making a person more susce...
Pentavalent rotavirus vaccine effectiveness among children in Shenzhen, China: A population-based test-negative design with directed acyclic graphs bias adjustment [0.03%]
五价轮状病毒疫苗对中国深圳儿童的效果研究：基于测试阴性设计和定向无环图偏差调整的群体水平研究
Zian Lin,Weiyi Cai,Yanan Liu et al.
Zian Lin et al.
Background: China's Notifiable Disease Reporting System comprehensively collects data on pediatric acute gastroenteritis cases from all levels of healthcare. This study evaluated the effectiveness of the pentavalent rotav...
Effect of fasting duration on mortality after COVID-19 infection: A retrospective analysis at a single institution [0.03%]
禁食持续时间对COVID-19感染后死亡率的影响：单一机构的回顾性分析
Naoko Takaku,Koji Hayashi,Hiromi Hayashi et al.
Naoko Takaku et al.
Background: The fasting duration in aspiration pneumonia negatively affects the patient's treatment duration and swallowing function. The relationship among serious COVID-19 infection, fasting duration, and patient progno...
The growing impact of nontuberculous mycobacteria: A multidisciplinary review of ecology, pathogenesis, diagnosis, and treatment [0.03%]
非结核分枝杆菌影响的日益扩大：生态、发病机制、诊断及治疗的多学科综述
Mehdi Roshdi Maleki,Seyyed Reza Moaddab
Mehdi Roshdi Maleki
Nontuberculous mycobacteria (NTM) are emerging pathogens responsible for a growing spectrum of diseases, particularly in individuals with underlying lung disorders or immune suppression. Once considered primarily environmental saprophytes, ...