Global distribution and genomic characteristics of Shigella: A genomic epidemiological study [0.03%]
志贺菌的全球分布及基因组特征：一项基因组流行病学研究
Jing Tao,Yang Liu,Xueqi Jiang et al.
Jing Tao et al.
Background: Shigella spp. remains a major cause of diarrheal disease globally, with escalating antimicrobial resistance and high transmissibility posing persistent public health threats. However, large-scale spatiotempora...
Next-generation sequencing: Driving a paradigm shift from pathogen detection to systems-level analysis [0.03%]
下一代测序：从病原体检测到系统层面分析的范式转变驱动力
Yu Peng,Yupu Wang,Liwen Liu et al.
Yu Peng et al.
The advent of advanced molecular technologies, particularly the widespread use of next-generation sequencing (NGS), has revolutionized the life sciences research landscape. NGS, characterized by high throughput, specificity, and sensitivity...
Multi-metal contamination shapes abundance, co-occurrence, and mobility potential of resistance and virulence genes in mining-impacted soils [0.03%]
金属共污染影响采矿区土壤中抗性基因和毒力基因的丰度、共发生及潜在传播能力
Qitao Zhang,Shixiong Li,Xiaobing Wang et al.
Qitao Zhang et al.
Background: Antimicrobial resistance is a growing global public health concern, posing a serious threat to human health. This study aimed to characterize the composition and distribution of microbial communities, metal re...
Changes in the burden of lower respiratory infections in China before and after the implementation of the national centralized drug procurement policy [0.03%]
中国实施国家药品集中采购政策前后下呼吸道感染疾病负担的变化趋势分析
Juan Hu,Yongzhong Tang,Duoduo Li et al.
Juan Hu et al.
Background: The implementation of the National Centralized Drug Procurement (NCDP) policy has had far-reaching effects. This study aims to assess the impact of the NCDP policy on the disease burden of lower respiratory in...
Oxidative stress index as a potent predictor of disease severity and inflammatory burden in hospitalized COVID-19 patients [0.03%]
氧化应激指数可预测住院COVID-19患者的疾病严重程度和炎症负荷
Abdisa Tufa Bedada,Tewodros Haile Gebremariam,Tsegahun Manyazewal et al.
Abdisa Tufa Bedada et al.
Background: While the acute phase of the COVID-19 pandemic has passed, understanding its pathophysiology remains critical for managing long-term sequelae and future viral threats. Oxidative stress is a proposed key driver...
Cerebral malaria in resource-limited African regions: Diagnostic and therapeutic challenges [0.03%]
非洲贫困地区 cerebral疟疾的诊断与治疗挑战
Jacob Kehinde Akintunde,Abimbola Mary Oluwajembola,Michael Abimbola Oladosu et al.
Jacob Kehinde Akintunde et al.
Cerebral malaria (CM) remains one of the most severe and life-threatening manifestations of Plasmodium falciparum infection, predominantly affecting children and pregnant women in Sub-Saharan Africa, where resource constraints compound diag...
Cost-effectiveness analysis of 23-valent pneumococcal polysaccharide vaccine for adults in China [0.03%]
中国23价肺炎球菌多糖疫苗成人接种的成本效益分析
Yamin Shu,Shuhua Tan,Yao Chen et al.
Yamin Shu et al.
Background: With population aging and the rising burden of chronic diseases, pneumococcal disease imposes increasing pressure on the healthcare system in China. This study evaluated the cost-effectiveness of the 23-valent...
Hepatitis E virus and renal injury: A review of pathogenesis, pathology, and clinical management [0.03%]
HEV相关肾损伤：发病机制、病理及临床管理研究进展
Jie Shen,Shujun Zhang
Jie Shen
Hepatitis E virus (HEV), particularly Orthohepevirus A genotypes 1-4, is a major cause of acute viral hepatitis, with genotypes 3 and 4 also recognized as important zoonotic pathogens and increasingly associated with extrahepatic renal mani...
From Nipah virus disease to disease X: Vigilance against the "infodemic" [0.03%]
从 nipah病毒病到未知传染病X：警惕"信息流行病"
Junkang Sun,Gang Wang
Junkang Sun
From dysbiosis to decolonization: The emerging role of fecal microbiota transplantation in antimicrobial resistance [0.03%]
从菌群失调到去定植：粪便微生物移植在抗菌药物耐药性中的新作用
Timotius Ivan Hariyanto
Timotius Ivan Hariyanto