Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19 [0.03%]
一些具有抗SARS-CoV-2和抗蛋白酶活性的天然化合物及其类似物作为COVID-19药物发现的先导分子
Biswanath Dinda,Manikarna Dinda,Subhajit Dinda et al.
Biswanath Dinda et al.
Currently an emerging human pathogenic coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused coronavirus disease 2019 (COVID-19) that has posed a serious threat to public health worldwide. As it is a novel severe...
Stereospecific antiseizure activity in mouse and rat epilepsy models by a pyridinium inhibitor of TNFα/NFκB signaling [0.03%]
TNFα/NFκB信号抑制剂的立体异构抗惊厥活性研究：小鼠和大鼠癫痫模型中的作用
Bette S Pollard,Zhiwei Wen,Kenneth A Jacobson et al.
Bette S Pollard et al.
Epilepsy affects over 50 million people worldwide and increases the risk of death. An intrinsic state of central inflammation, mainly driven by TNFα/NFκB signaling, may contribute to the refractory nature of some epilepsies. We have there...