Synthesis of novel derivatives from machilin C/D as antiproliferative agents against triple negative breast cancer [0.03%]
合成马奇林C/D的新衍生物作为三阴性乳腺癌抗增殖剂的研究
Alyson M Ackerman,Chibuzor Olewele,Bert C Lynn et al.
Alyson M Ackerman et al.
Lignans are small polyphenolic compounds that play an active role in plant defense against pathogens and predators. Recently, lignan machilin D was reported to be effective as an anti-tumorigenic agent in triple negative breast cancer (TNBC...
Improved in vitro potency of Clofazimine derivatives against Neisseria species [0.03%]
克洛法齐明衍生物的体外活性改善可有效抑制奈瑟氏球菌属细菌生长
Masahide Yano,Jessica M Lawson-Rulli,Reilly M Coates et al.
Masahide Yano et al.
Globally, millions of infections that are resistant to antimicrobial agents are reported annually, leading to more than 700,000 fatalities. Among all, challenges arise particularly from nontuberculosis mycobacterial (NTM) and Gram-negative ...
Investigating novel thiazolyl-indazole derivatives as scaffolds for SARS-CoV-2 MPro inhibitors [0.03%]
研究新型噻唑基-吲唑衍生物作为SARS-CoV-2 Mpro抑制剂的骨架
Justin Airas,Catherine A Bayas,Abdellah N&#x;Ait Ousidi et al.
Justin Airas et al.
COVID-19 is a global pandemic caused by infection with the SARS-CoV-2 virus. Remdesivir, a SARS-CoV-2 RNA polymerase inhibitor, is the only drug to have received widespread approval for treatment of COVID-19. The SARS-CoV-2 main protease en...
Ripul Mehrotra,Satyendra N Shukla,Pratiksha Gaur
Ripul Mehrotra
In light of the current SARS-CoV-2 outbreak, about one million research papers (articles, reviews, communications, etc.) were published in the last one and a half years. It was also noticed that in the past few years; infectious diseases, m...
Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors [0.03%]
茋类化合物茋茋作为一种潜在的NLRP3炎性小体抑制剂骨架分子
Pritam Thapa,Sunil P Upadhyay,Vikas Singh et al.
Pritam Thapa et al.
Overactivated NLRP3 inflammasome has been shown to associate with an increasing number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1-catalyzed formation of active pro-inflammatory cytokines (IL-1β and IL-...
Vaishali M Patil,Saroj Verma,Neeraj Masand
Vaishali M Patil
The well-known anti-helminthic drug ivermectin (IVM) has been established as an example of drug repurposing for the management of SARS-CoV-2 infection. Various study has been done to understand the inhibitory mechanism of IVM against SARS-C...
Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment [0.03%]
达鲁那韦乙醇酸盐：作为抗HIV药物在COVID-19治疗中的新应用
Vivek P Chavda,Normi Gajjar,Nirav Shah et al.
Vivek P Chavda et al.
Antivirals already on the market and expertise gained from the SARS and MERS outbreaks are gaining momentum as the most effective way to combat the coronavirus outbreak. SARS-CoV-2 has caused considerable mortality due to respiratory failur...
Impact of mono- and di-β-galactose moieties in in vitro / in vivo anticancer efficacy of pyropheophorbide-carbohydrate conjugates by photodynamic therapy [0.03%]
吡ropheohyboride-碳水化合物偶联物通过光动力疗法对体内外抗癌功效的单和二-β-半乳糖基的影响
Mykhaylo Dukh,Joseph Cacaccio,Farukh A Durrani et al.
Mykhaylo Dukh et al.
To investigate the impact of mono- and di-β-galactose moieties in tumor uptake and photodynamic therapy (PDT) efficacy, HPPH [3-(1'-hexyloxy)ethyl-3-devinylpyropheophorobide-a], the meso pyropheophorbide-a [3-ethyl-3-devinyl-pyropheophorbi...
Recent progress of surface plasmon resonance in the development of coronavirus disease-2019 drug candidates [0.03%]
表面等离子共振技术在新冠病毒药物研发中的新进展
Qian Wang,Zhenming Liu
Qian Wang
At the end of 2019, the new coronavirus caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly raged, bringing a severe public health crisis to the world. It is urgent to discover suitable drugs and treatment regime...
Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19 [0.03%]
一些具有抗SARS-CoV-2和抗蛋白酶活性的天然化合物及其类似物作为COVID-19药物发现的先导分子
Biswanath Dinda,Manikarna Dinda,Subhajit Dinda et al.
Biswanath Dinda et al.
Currently an emerging human pathogenic coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused coronavirus disease 2019 (COVID-19) that has posed a serious threat to public health worldwide. As it is a novel severe...