Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers [0.03%]
正性负性条件刺激反应可区分酒精依赖的神经亚型
Yu Chen,Chiang-Shan R Li
Yu Chen
Craving reflects the subjective urge to use drugs and can be triggered by both positive and negative emotional states. No studies have systematically investigated the relative roles of these mechanisms in the pathophysiology of substance mi...
Habitual behaviour associated with exposure to high-calorie diet is prevented by an orexin-receptor-1 antagonist [0.03%]
食欲肽受体1拮抗剂能抑制高热量食物引起的不良饮食习惯
Sam Merlin,Teri M Furlong
Sam Merlin
Habitual actions, which are associated with addictive behaviours, contribute to the loss of control of food seeking seen following exposure to calorie-dense foods in rats. Antagonism of orexin-receptor-1 (ORX-R1) has been shown to reduce a ...
Naltrexone engages a brain reward network in the presence of reward-predictive distractor stimuli in males [0.03%]
纳曲酮在存在与奖励预测相关的分散刺激物时激活男性大脑奖赏网络
Cory N Spencer,Amanda Elton,Samantha Dove et al.
Cory N Spencer et al.
The non-selective opioid receptor antagonist, naltrexone is one of the most prescribed medications for treating alcohol and opioid addiction. Despite decades of clinical use, the mechanism(s) by which naltrexone reduces addictive behavior r...
Review of strategies to investigate low sample return rates in remote tobacco trials: A call to action for more user-centered design research [0.03%]
远程烟草试验中低样本回收率的调查策略回顾：呼吁开展更多以用户为中心的设计研究
Roger Vilardaga,Johannes Thrul,Anthony DeVito et al.
Roger Vilardaga et al.
Remote collection of biomarkers of tobacco use in clinical trials poses significant challenges. A recent meta-analysis and scoping review of the smoking cessation literature indicated that sample return rates are low and that new methods ar...
Role of untargeted omics biomarkers of exposure and effect for tobacco research [0.03%]
非目标型组学生物标志物在烟草研究中的作用
Peter G Shields
Peter G Shields
Tobacco research remains a clear priority to improve individual and population health, and has recently become more complex with emerging combustible and noncombustible tobacco products. The use of omics methods in prevention and cessation ...
Alcohol-drinking during later life by C57BL/6J mice induces sex- and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate receptors and neuropathology markers [0.03%]
成年期饮酒通过C57BL/6J小鼠诱导海马和前额叶皮质中谷氨酸受体及神经病理标志物的性别和年龄依赖性变化
Karen K Szumlinski,Jessica N Herbert,Brenda Mejia Espinoza et al.
Karen K Szumlinski et al.
Heavy drinking can induce early-onset dementia and increase the likelihood of the progression and severity of Alzheimer's Disease and related dementias (ADRD). Recently, we showed that alcohol-drinking by mature adult C57BL/6J mice induces ...
Prelimbic cortex and nucleus accumbens core resting state signaling dynamics as a biomarker for cocaine seeking behaviors [0.03%]
前扣带回皮层和伏隔核核团静息态信号动力学作为可卡因寻购行为生物标志物的研究
Metika L Ngbokoli,Joaquin E Douton,Regina M Carelli
Metika L Ngbokoli
Substance use disorders (SUDs) are characterized by maladaptive signaling in the prefrontal cortex and associated regions, however precisely how these drug-induced abnormalities may be linked to drug seeking/taking behaviors is not well und...
The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke [0.03%]
性激素在针对吸烟女性压力引起的烟草渴望、压力反应和吸烟方面使用胍法辛的作用
MacKenzie R Peltier,Sherry A McKee
MacKenzie R Peltier
Women who smoke are particularly vulnerable to tobacco craving, smoking behaviors, and relapse in the context of stress when compared to men who smoke. One factor in this sex difference may be sex hormones, including estradiol and progester...
No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis [0.03%]
阿片类物质使用者表观遗传学衰老加速的证据不足：病例对照研究
Jermaine D Jones,Suky Martinez,Ingrid Gonzalez et al.
Jermaine D Jones et al.
This study sought to assess the association between illicit opioid use and accelerated epigenetic aging (A.K.A. DNAm Age) among people of African ancestry who use heroin. DNA was obtained from participants with opioid use disorder (OUD) who...
Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration [0.03%]
与海洛因使用增加和纳络酮诱导的海洛因自我给药增加相关的扣带回环路
M J Scarlata,R J Keeley,S A Carmack et al.
M J Scarlata et al.
Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of control over intake and the development of a negative emotional state when access to opioids is denied. Using functional magnetic resonance imaging (fMRI...