Concurrent consumption of ethanol and corticosterone during adolescence alters neuroimmune sensitivity in Sprague Dawley rats [0.03%]
青春期同时摄入乙醇和皮质酮会改变Sprague-Dawley大鼠的神经免疫敏感性
Ashley Lutzke,Ariana L Velazquez,Sarah Trapp et al.
Ashley Lutzke et al.
Chronic stress and alcohol consumption influence various features of neuroimmune reactivity, including neurobehavioral outcomes, induction of neuroimmune genes, blood-brain barrier (BBB) permeability, and core body temperature regulation. T...
Medial prefrontal cortical neurotransmitters reactive to relapse-promoting and relapse-suppressing cues in male rats trained to self-administer cocaine or alcohol [0.03%]
与可卡因或酒精自我给药雄性大鼠复发有关的前额叶皮层介质奖励线索反应性研究
Hermina Nedelescu,Cristina Miliano,Grant E Wagner et al.
Hermina Nedelescu et al.
Environmental cues signaling drug availability (S+) vs. omission (S-) each recruit specific prefrontal cortical neurons to promote vs. suppress drug seeking in rats, suggesting similarly cue-specific neurotransmission regulates such behavio...
Predator scent stress reduces oxycodone self-administration and the nucleus accumbens dopamine response to oxycodone in female rats [0.03%]
捕食者气味压力减少雌性大鼠自陷性寻求氧化可待因及氧化可待因核多胺体多巴胺反应
Courtney S Wilkinson,Siya Bhutani,Wonn Pyon et al.
Courtney S Wilkinson et al.
Post-traumatic stress disorder (PTSD) develops in a sub-population of people exposed to trauma and is highly comorbid with opioid use disorder (OUD). The neurobiology of comorbid PTSD+OUD, especially with respect to sex differences, is poor...
The need to incorporate polysubstance use in neuropsychopharmacology research: Biological lessons and new opportunities [0.03%]
神经精神药理学研究中纳入多种物质使用的必要性：生物学启示与新的机遇
Max E Joffe,Susan M Ferguson,Nick W Gilpin et al.
Max E Joffe et al.
Critical evaluation and refinement of animal models is essential for neuroscientists to understand complex physiological and pathological processes related to psychiatric diseases. In general, preclinical studies modeling drug dependence an...
Physiological neuroadaptations in prefrontal cortical regulation of abstinence and cue-induced relapse to cocaine seeking [0.03%]
Cocaine戒断和线索诱发复吸的前额皮质生理神经适应性研究
Saurabh S Kokane,Chevin M Ray,Ayteria D Crow et al.
Saurabh S Kokane et al.
Biphasic molecular adaptations in pyramidal neurons (PNs) projecting from prelimbic (PL) cortex to the nucleus accumbens (NAc) (PL→NAc PNs) are hallmarks of early withdrawal vs. later abstinence from cocaine. However, whether biphasic elec...
Sage L Morison,Luan B Doster,Andrew D Vigotsky et al.
Sage L Morison et al.
Opioids have strong addictive and rewarding effects, largely attributed to their interaction with the dopamine (DA) system. Within the ventral tegmental area (VTA), opioids increase DA neural activity by disinhibiting-or decreasing the toni...
Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner [0.03%]
酒精戒断通过一种抑制性神经元和性别特异性方式改变腹侧前扣带回皮层的抑制性格局
Sema G Quadir,S Danyal Zaidi,Meredith G Cone et al.
Sema G Quadir et al.
Alcohol use disorder (AUD) is highly prevalent and associated with substantial morbidity and mortality. While there are currently three FDA-approved medications for AUD, none specifically target the withdrawal/negative affect stage of AUD, ...
Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats [0.03%]
异质种系大鼠下丘脑视交叉上核中长期奥施康定给药后持续存在的性别特异性转录标志在戒断和不使用药物期间的出现
Tara C Delorme,Snehal Sambare,Benjamin R Williams et al.
Tara C Delorme et al.
Opioid use disorder (OUD) is a major public health problem. Sleep and circadian disruptions are recognized as hallmarks of substance use disorders, often emerging during withdrawal and lasting into abstinence. Little is known about the impa...
Presence of distinct operant phenotypes and transient withdrawal-induced escalation of operant ethanol intake in female rats [0.03%]
雌性大鼠中存在不同的操作体征和短暂的戒断诱导的操作性乙醇摄入量增加现象
Joseph R Pitock,Shannon R Wheeler,Arleen Perez Ayala et al.
Joseph R Pitock et al.
Operant self-administration is frequently used to investigate the neurobiological mechanisms underlying alcohol seeking and drinking and to evaluate treatments of alcohol use disorder (AUD). Although widely used by the research community, t...
Sex-dependent hippocampal atrophy among people with methamphetamine-use experience [0.03%]
甲基安非他命使用者海马区性别依赖性萎缩现象研究
Hillary Schwarb,Robert J Roy,Alisha L Schaefer et al.
Hillary Schwarb et al.
As methamphetamine use rates continue to climb, understanding its relationship with physical, mental, and cognitive decline is critical. While memory difficulties are common, the underlying neurobiology of these deficits are not well unders...