The central amygdala corticotropin releasing factor system regulates anxiety-like behavior in an age- and sex- dependent manner in rats [0.03%]
下丘脑视前区催乳素释放肽系统以年龄和性别依赖方式调节大鼠类似焦虑的行为
Kelcie C Schatz,Margaret Agajanov,Elena I Varlinskaya et al.
Kelcie C Schatz et al.
The corticotropin releasing factor (CRF) system is a key regulator of anxiety-like behavior and a major contributor to addiction. The canonical anxiogenic role of CRF has been largely based on CRF manipulations in adult male rodents, partic...
Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose [0.03%]
阿片类药物使用障碍中的海马体积和脑tau病理与非致死性阿片类药物中毒的关系
Delaney McKinstry,Zhenhao Shi,Astrid P Ramos-Rolón et al.
Delaney McKinstry et al.
Opioid use disorder (OUD) is associated with high rates of overdose (OD)-related morbidity and mortality. OD can cause hypoxic-ischemic injury to oxygen-sensitive brain regions such as the hippocampus. Post-mortem studies show Alzheimer's d...
Dysregulation of inhibitory control in young adult binge drinkers: Neuroimaging evidence of gender differences associated with misusing alcohol to cope with negative affect [0.03%]
青年期酗酒者抑制控制失调：利用神经影像学证据揭示情绪应对型酒精滥用的性别差异
Austin B Alderson Myers,David R White,Ksenija Marinkovic
Austin B Alderson Myers
Impaired inhibitory control contributes to compulsive drinking and increased risk of alcohol misuse. While the neural underpinnings of inhibitory control have been well documented, imaging evidence in binge drinkers (BDs) is scarce. Notably...
Multiple memory object-drug association task (MODAT) for the study of polydrug associations [0.03%]
用于研究多药关联的多个记忆对象-药物关联任务(MODAT)
Madalyn Hafenbreidel,Thomas Vaissiere,Erica J Young et al.
Madalyn Hafenbreidel et al.
Polysubstance use is common among individuals with substance use disorder (SUD). However, the underlying neurobiology of the complex interactions between different drug classes is understudied. Further, drug associations can serve as relaps...
Concurrent consumption of ethanol and corticosterone during adolescence alters neuroimmune sensitivity in Sprague Dawley rats [0.03%]
青春期同时摄入乙醇和皮质酮会改变Sprague-Dawley大鼠的神经免疫敏感性
Ashley Lutzke,Ariana L Velazquez,Sarah Trapp et al.
Ashley Lutzke et al.
Chronic stress and alcohol consumption influence various features of neuroimmune reactivity, including neurobehavioral outcomes, induction of neuroimmune genes, blood-brain barrier (BBB) permeability, and core body temperature regulation. T...
Medial prefrontal cortical neurotransmitters reactive to relapse-promoting and relapse-suppressing cues in male rats trained to self-administer cocaine or alcohol [0.03%]
与可卡因或酒精自我给药雄性大鼠复发有关的前额叶皮层介质奖励线索反应性研究
Hermina Nedelescu,Cristina Miliano,Grant E Wagner et al.
Hermina Nedelescu et al.
Environmental cues signaling drug availability (S+) vs. omission (S-) each recruit specific prefrontal cortical neurons to promote vs. suppress drug seeking in rats, suggesting similarly cue-specific neurotransmission regulates such behavio...
Predator scent stress reduces oxycodone self-administration and the nucleus accumbens dopamine response to oxycodone in female rats [0.03%]
捕食者气味压力减少雌性大鼠自陷性寻求氧化可待因及氧化可待因核多胺体多巴胺反应
Courtney S Wilkinson,Siya Bhutani,Wonn Pyon et al.
Courtney S Wilkinson et al.
Post-traumatic stress disorder (PTSD) develops in a sub-population of people exposed to trauma and is highly comorbid with opioid use disorder (OUD). The neurobiology of comorbid PTSD+OUD, especially with respect to sex differences, is poor...
The need to incorporate polysubstance use in neuropsychopharmacology research: Biological lessons and new opportunities [0.03%]
神经精神药理学研究中纳入多种物质使用的必要性：生物学启示与新的机遇
Max E Joffe,Susan M Ferguson,Nick W Gilpin et al.
Max E Joffe et al.
Critical evaluation and refinement of animal models is essential for neuroscientists to understand complex physiological and pathological processes related to psychiatric diseases. In general, preclinical studies modeling drug dependence an...
Physiological neuroadaptations in prefrontal cortical regulation of abstinence and cue-induced relapse to cocaine seeking [0.03%]
Cocaine戒断和线索诱发复吸的前额皮质生理神经适应性研究
Saurabh S Kokane,Chevin M Ray,Ayteria D Crow et al.
Saurabh S Kokane et al.
Biphasic molecular adaptations in pyramidal neurons (PNs) projecting from prelimbic (PL) cortex to the nucleus accumbens (NAc) (PL→NAc PNs) are hallmarks of early withdrawal vs. later abstinence from cocaine. However, whether biphasic elec...
Sage L Morison,Luan B Doster,Andrew D Vigotsky et al.
Sage L Morison et al.
Opioids have strong addictive and rewarding effects, largely attributed to their interaction with the dopamine (DA) system. Within the ventral tegmental area (VTA), opioids increase DA neural activity by disinhibiting-or decreasing the toni...