Nucleus accumbens shell neurons' early sensitivity to cocaine is associated with future increases in drug intake [0.03%]
伏隔核壳神经元早期对可卡因的敏感性与未来药物摄入量的增加有关
Ashley K Crawley,Anirudh Sharma,Kevin R Coffey et al.
Ashley K Crawley et al.
The striatum, both dorsal and ventral, is strongly implicated in substance use disorder. Chronic consumption of abused substances, such as cocaine, can cause an oversaturation of mesostriatal dopamine, which results in alterations in the fi...
Fatty acid-binding protein 5 differentially impacts dopamine signaling independent of sex and environment [0.03%]
脂肪酸结合蛋白5独立于性别和环境差异性影响多巴胺信号转导
Brittany J Richardson,John Hamilton,Nicole Roeder et al.
Brittany J Richardson et al.
Epidermal/brain fatty acid-binding protein 5 (FABP5) plays an integral role in the intracellular trafficking of bioactive lipids/endocannabinoids and the subsequent initiation of cellular cascades affecting cannabinoid and dopamine (DA) sys...
Acquired Alterations in Nucleus Accumbens Responsiveness to a Cocaine-Paired Discriminative Stimulus Preceding Rats' Daily Cocaine Consumption [0.03%]
有关伏隔核对日常可卡因摄取前配有毒物的辨别刺激产生反应性获得改变的影响
David J Estrin,Julianna M Kulik,Nicholas J Beacher et al.
David J Estrin et al.
Resumption of drug taking is a primary focus for substance use disorder research and can be triggered by drug-associated environmental stimuli. The Nucleus Accumbens (NAc) is a key brain region which guides motivated behavior and is implica...
DREADD activation of the lateral orbitofrontal increases cocaine-taking and cocaine-seeking in male and female rats during intermittent access self-administration under risky conditions [0.03%]
光隙前额叶皮层区DREADDs激活可增加间歇接触条件下雄性和雌性大鼠在风险环境中的可卡因摄取和寻求行为
Zackari D Murphy,Ruth Mulugeta,Alex Tran et al.
Zackari D Murphy et al.
Addiction is a disorder that can be characterized in part as the constant pursuit of a particular substance despite negative consequences. Although the orbitofrontal cortex (OFC) is known to regulate risk-taking more generally and be critic...
Genomic medicine to reduce tobacco and related disorders: Translation to precision prevention and treatment [0.03%]
基因组医学减少烟草及相关疾病：精准预防和治疗的转化研究
Li-Shiun Chen,Timothy B Baker,Alex Ramsey et al.
Li-Shiun Chen et al.
Genomic medicine can enhance prevention and treatment. First, we propose that advances in genomics have the potential to enhance assessment of disease risk, improve prognostic predictions, and guide treatment development and application. Cl...
Advancing Biomarkers for Treatment of Smoking and Nicotine Dependence: An Overview [0.03%]
吸烟与尼古丁依赖治疗生物标志物研究进展概述
Jonathan D Pollock,Kay Wanke,Wilson M Compton
Jonathan D Pollock
The special issue on Biomarkers of Nicotine and Tobacco Dependence reviews the science for precision treatment of nicotine dependence and future opportunities for research on biomarkers for inclusion in tobacco product cessation and switchi...
Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats [0.03%]
急性酒精诱导的成人组外侧皮层网络的功能连接变化较青春期大且具有剂量依赖性
Sung-Ho Lee,Tatiana A Shnitko,Li-Ming Hsu et al.
Sung-Ho Lee et al.
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior little is known...
Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice [0.03%]
社交整合多物质(SIP)系统：一种用于群居小鼠连续监测多物质液体摄取的开源解决方案
Katrina Wong,Ziheng Christina Wang,Makenzie Patarino et al.
Katrina Wong et al.
Despite impressive results from neuroscience research using rodent models, there is a paucity of successful translation from preclinical findings to effective pharmacological interventions for treatment of substance use disorder (SUD) in hu...
Dana Lengel,Paul J Kenny
Dana Lengel
Diseases associated with nicotine dependence in the form of habitual tobacco use are a major cause of premature death in the United States. The majority of tobacco smokers will relapse within the first month of attempted abstinence. Smoking...
Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review [0.03%]
Cocaine戒断引起的精神焦虑的脑机制：综述分析
Britton R Barbee,Shannon L Gourley
Britton R Barbee
Cocaine use disorder (CUD) is a significant public health issue that generates substantial personal, familial, and economic burdens. Still, there are no FDA-approved pharmacotherapies for CUD. Cocaine-dependent individuals report anxiety du...