Genomic medicine to reduce tobacco and related disorders: Translation to precision prevention and treatment [0.03%]
基因组医学减少烟草及相关疾病：精准预防和治疗的转化研究
Li-Shiun Chen,Timothy B Baker,Alex Ramsey et al.
Li-Shiun Chen et al.
Genomic medicine can enhance prevention and treatment. First, we propose that advances in genomics have the potential to enhance assessment of disease risk, improve prognostic predictions, and guide treatment development and application. Cl...
Advancing Biomarkers for Treatment of Smoking and Nicotine Dependence: An Overview [0.03%]
吸烟与尼古丁依赖治疗生物标志物研究进展概述
Jonathan D Pollock,Kay Wanke,Wilson M Compton
Jonathan D Pollock
The special issue on Biomarkers of Nicotine and Tobacco Dependence reviews the science for precision treatment of nicotine dependence and future opportunities for research on biomarkers for inclusion in tobacco product cessation and switchi...
Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats [0.03%]
急性酒精诱导的成人组外侧皮层网络的功能连接变化较青春期大且具有剂量依赖性
Sung-Ho Lee,Tatiana A Shnitko,Li-Ming Hsu et al.
Sung-Ho Lee et al.
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior little is known...
Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice [0.03%]
社交整合多物质(SIP)系统：一种用于群居小鼠连续监测多物质液体摄取的开源解决方案
Katrina Wong,Ziheng Christina Wang,Makenzie Patarino et al.
Katrina Wong et al.
Despite impressive results from neuroscience research using rodent models, there is a paucity of successful translation from preclinical findings to effective pharmacological interventions for treatment of substance use disorder (SUD) in hu...
Dana Lengel,Paul J Kenny
Dana Lengel
Diseases associated with nicotine dependence in the form of habitual tobacco use are a major cause of premature death in the United States. The majority of tobacco smokers will relapse within the first month of attempted abstinence. Smoking...
Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review [0.03%]
Cocaine戒断引起的精神焦虑的脑机制：综述分析
Britton R Barbee,Shannon L Gourley
Britton R Barbee
Cocaine use disorder (CUD) is a significant public health issue that generates substantial personal, familial, and economic burdens. Still, there are no FDA-approved pharmacotherapies for CUD. Cocaine-dependent individuals report anxiety du...
Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers [0.03%]
正性负性条件刺激反应可区分酒精依赖的神经亚型
Yu Chen,Chiang-Shan R Li
Yu Chen
Craving reflects the subjective urge to use drugs and can be triggered by both positive and negative emotional states. No studies have systematically investigated the relative roles of these mechanisms in the pathophysiology of substance mi...
Habitual behaviour associated with exposure to high-calorie diet is prevented by an orexin-receptor-1 antagonist [0.03%]
食欲肽受体1拮抗剂能抑制高热量食物引起的不良饮食习惯
Sam Merlin,Teri M Furlong
Sam Merlin
Habitual actions, which are associated with addictive behaviours, contribute to the loss of control of food seeking seen following exposure to calorie-dense foods in rats. Antagonism of orexin-receptor-1 (ORX-R1) has been shown to reduce a ...
Naltrexone engages a brain reward network in the presence of reward-predictive distractor stimuli in males [0.03%]
纳曲酮在存在与奖励预测相关的分散刺激物时激活男性大脑奖赏网络
Cory N Spencer,Amanda Elton,Samantha Dove et al.
Cory N Spencer et al.
The non-selective opioid receptor antagonist, naltrexone is one of the most prescribed medications for treating alcohol and opioid addiction. Despite decades of clinical use, the mechanism(s) by which naltrexone reduces addictive behavior r...
Review of strategies to investigate low sample return rates in remote tobacco trials: A call to action for more user-centered design research [0.03%]
远程烟草试验中低样本回收率的调查策略回顾：呼吁开展更多以用户为中心的设计研究
Roger Vilardaga,Johannes Thrul,Anthony DeVito et al.
Roger Vilardaga et al.
Remote collection of biomarkers of tobacco use in clinical trials poses significant challenges. A recent meta-analysis and scoping review of the smoking cessation literature indicated that sample return rates are low and that new methods ar...