Sexually dimorphic effects of a modified adolescent social isolation paradigm on behavioral risk factors of alcohol use disorder in Long Evans Rats [0.03%]
青春期社会隔离范式改变对Long Evans大鼠酒精使用障碍行为风险因素的性别二态影响
Olivia A Ortelli,Stacy R Pitcairn,Christina H Dyson et al.
Olivia A Ortelli et al.
Early life stress (ELS) is a major risk factor for alcohol use disorder (AUD) and comorbid neuropsychiatric conditions. We previously demonstrated that an adolescent social isolation (aSI) model of ELS significantly increased behavioral ris...
Adolescent alcohol disrupts development of noradrenergic neurons in the nucleus of the tractus solitarius and enhances stress behaviors in adulthood in mice in a sex specific manner [0.03%]
青春期酒精会以性别特异性方式干扰孤束核中去甲肾上腺素神经元的发育，并增加成年小鼠的压力行为
Liz A Aguilar,Caitlin R Coker,Zari McCullers et al.
Liz A Aguilar et al.
Alcohol use disorders (AUDs) are common mental health issues worldwide and can lead to other chronic diseases. Stress is a major factor in the development and continuation of AUDs, and adolescent alcohol exposure can lead to enhanced stress...
Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use [0.03%]
雌二醇和μ阿片受体介导的奖赏：雌激素受体在阿片类药物使用中的作用
Sarah B Ethridge,Mark A Smith
Sarah B Ethridge
Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals. This review focuses on the role of ovaria...
Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder [0.03%]
酒精使用障碍小鼠模型前额皮层的谷氨酸能适应性变化
Mahum T Siddiqi,Dhruba Podder,Amanda R Pahng et al.
Mahum T Siddiqi et al.
Alcohol use disorder (AUD) produces cognitive deficits, indicating a shift in prefrontal cortex (PFC) function. PFC glutamate neurotransmission is mostly mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic rece...
Hypocretin / Orexin Receptor 1 Knockdown in GABA or Dopamine Neurons in the Ventral Tegmental Area Differentially Impact Mesolimbic Dopamine and Motivation for Cocaine [0.03%]
腹腔缝合区GABA或多巴胺神经元中的下丘脑/ orexin受体1敲低对中隔多巴胺和可卡因的动机产生不同的影响
Emily M Black,Shanna B Samels,Wei Xu et al.
Emily M Black et al.
The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-admini...
Synaptic remodeling of GluA1 and GluA2 expression in the nucleus accumbens promotes susceptibility to cognitive deficits concomitant with downstream GSK3 β mediated neurotoxicity in female mice during abstinence from voluntary oral methamphetamine [0.03%]
小鼠自愿口服methamphetamine戒断期间，成纤维细胞生长因子受体在伏隔核中的突触重塑促进GluA1和GluA2表达，从而导致认知缺陷并伴有下游GSK3 β介导的神经毒性作用
Nicoletta Memos,Jorge A Avila,Edgar Rodriguez et al.
Nicoletta Memos et al.
Stimulant-use disorders can present with long-term cognitive and mental health deficits. Little is known about the underlying molecular mechanisms perpetuating sex differences in cognitive and behavioral deficits in preclinical models of ad...
Chronic alcohol exposure differentially alters calcium activity of striatal cell populations during actions [0.03%]
慢性酒精暴露会改变纹状体细胞群体在行为过程中的钙离子活性
Emily T Baltz,Rafael Renteria,Christina M Gremel
Emily T Baltz
Alcohol Use Disorder (AUD) can induce long lasting alterations to executive function. This includes altered action control, which can manifest as dysfunctional goal-directed control. Cortical and striatal circuits mediate goal-directed cont...
Recent advances in drug discovery efforts targeting the sigma 1 receptor system: Implications for novel medications designed to reduce excessive drug and food seeking [0.03%]
近年特异性靶向σ-1受体系统的药物研发新进展及其对减少过度用药和摄食行为的新型治疗药物的重要意义
Liam G Knowles,Abanoub J Armanious,Youyi Peng et al.
Liam G Knowles et al.
Psychiatric disorders characterized by uncontrolled reward seeking, such as substance use disorders (SUDs), alcohol use disorder (AUD) and some eating disorders, impose a significant burden on individuals and society. Despite their high pre...
Individual differences in late positive potential amplitude and theta power predict cue-induced eating [0.03%]
延迟正向电位和theta振幅的个体差异可预测线索诱发的饮食行为
Kyla D Gibney,George Kypriotakis,Francesco Versace
Kyla D Gibney
Cue-induced reward-seeking behaviors are regulated by both the affective and cognitive control systems of the brain. This study aimed at investigating how individual differences in affective and cognitive responses to cues predicting food r...
PiRATeMC: A highly flexible, scalable, and low-cost system for obtaining high quality video recordings for behavioral neuroscience [0.03%]
PiRATeMC：一种高度灵活、可扩展且低成本的系统，用于获得行为神经科学的高质量视频记录
Samuel W Centanni,Alexander C W Smith
Samuel W Centanni
With the rapidly accelerating adoption of machine-learning based rodent behavioral tracking tools, there is an unmet need for a method of acquiring high quality video data that is scalable, flexible, and relatively low-cost. Many experiment...