Hypocretin / Orexin Receptor 1 Knockdown in GABA or Dopamine Neurons in the Ventral Tegmental Area Differentially Impact Mesolimbic Dopamine and Motivation for Cocaine [0.03%]
腹腔缝合区GABA或多巴胺神经元中的下丘脑/ orexin受体1敲低对中隔多巴胺和可卡因的动机产生不同的影响
Emily M Black,Shanna B Samels,Wei Xu et al.
Emily M Black et al.
The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-admini...
Synaptic remodeling of GluA1 and GluA2 expression in the nucleus accumbens promotes susceptibility to cognitive deficits concomitant with downstream GSK3 β mediated neurotoxicity in female mice during abstinence from voluntary oral methamphetamine [0.03%]
小鼠自愿口服methamphetamine戒断期间，成纤维细胞生长因子受体在伏隔核中的突触重塑促进GluA1和GluA2表达，从而导致认知缺陷并伴有下游GSK3 β介导的神经毒性作用
Nicoletta Memos,Jorge A Avila,Edgar Rodriguez et al.
Nicoletta Memos et al.
Stimulant-use disorders can present with long-term cognitive and mental health deficits. Little is known about the underlying molecular mechanisms perpetuating sex differences in cognitive and behavioral deficits in preclinical models of ad...
Chronic alcohol exposure differentially alters calcium activity of striatal cell populations during actions [0.03%]
慢性酒精暴露会改变纹状体细胞群体在行为过程中的钙离子活性
Emily T Baltz,Rafael Renteria,Christina M Gremel
Emily T Baltz
Alcohol Use Disorder (AUD) can induce long lasting alterations to executive function. This includes altered action control, which can manifest as dysfunctional goal-directed control. Cortical and striatal circuits mediate goal-directed cont...
Recent advances in drug discovery efforts targeting the sigma 1 receptor system: Implications for novel medications designed to reduce excessive drug and food seeking [0.03%]
近年特异性靶向σ-1受体系统的药物研发新进展及其对减少过度用药和摄食行为的新型治疗药物的重要意义
Liam G Knowles,Abanoub J Armanious,Youyi Peng et al.
Liam G Knowles et al.
Psychiatric disorders characterized by uncontrolled reward seeking, such as substance use disorders (SUDs), alcohol use disorder (AUD) and some eating disorders, impose a significant burden on individuals and society. Despite their high pre...
Individual differences in late positive potential amplitude and theta power predict cue-induced eating [0.03%]
延迟正向电位和theta振幅的个体差异可预测线索诱发的饮食行为
Kyla D Gibney,George Kypriotakis,Francesco Versace
Kyla D Gibney
Cue-induced reward-seeking behaviors are regulated by both the affective and cognitive control systems of the brain. This study aimed at investigating how individual differences in affective and cognitive responses to cues predicting food r...
PiRATeMC: A highly flexible, scalable, and low-cost system for obtaining high quality video recordings for behavioral neuroscience [0.03%]
PiRATeMC：一种高度灵活、可扩展且低成本的系统，用于获得行为神经科学的高质量视频记录
Samuel W Centanni,Alexander C W Smith
Samuel W Centanni
With the rapidly accelerating adoption of machine-learning based rodent behavioral tracking tools, there is an unmet need for a method of acquiring high quality video data that is scalable, flexible, and relatively low-cost. Many experiment...
Nucleus accumbens shell neurons' early sensitivity to cocaine is associated with future increases in drug intake [0.03%]
伏隔核壳神经元早期对可卡因的敏感性与未来药物摄入量的增加有关
Ashley K Crawley,Anirudh Sharma,Kevin R Coffey et al.
Ashley K Crawley et al.
The striatum, both dorsal and ventral, is strongly implicated in substance use disorder. Chronic consumption of abused substances, such as cocaine, can cause an oversaturation of mesostriatal dopamine, which results in alterations in the fi...
Fatty acid-binding protein 5 differentially impacts dopamine signaling independent of sex and environment [0.03%]
脂肪酸结合蛋白5独立于性别和环境差异性影响多巴胺信号转导
Brittany J Richardson,John Hamilton,Nicole Roeder et al.
Brittany J Richardson et al.
Epidermal/brain fatty acid-binding protein 5 (FABP5) plays an integral role in the intracellular trafficking of bioactive lipids/endocannabinoids and the subsequent initiation of cellular cascades affecting cannabinoid and dopamine (DA) sys...
Acquired Alterations in Nucleus Accumbens Responsiveness to a Cocaine-Paired Discriminative Stimulus Preceding Rats' Daily Cocaine Consumption [0.03%]
有关伏隔核对日常可卡因摄取前配有毒物的辨别刺激产生反应性获得改变的影响
David J Estrin,Julianna M Kulik,Nicholas J Beacher et al.
David J Estrin et al.
Resumption of drug taking is a primary focus for substance use disorder research and can be triggered by drug-associated environmental stimuli. The Nucleus Accumbens (NAc) is a key brain region which guides motivated behavior and is implica...
DREADD activation of the lateral orbitofrontal increases cocaine-taking and cocaine-seeking in male and female rats during intermittent access self-administration under risky conditions [0.03%]
光隙前额叶皮层区DREADDs激活可增加间歇接触条件下雄性和雌性大鼠在风险环境中的可卡因摄取和寻求行为
Zackari D Murphy,Ruth Mulugeta,Alex Tran et al.
Zackari D Murphy et al.
Addiction is a disorder that can be characterized in part as the constant pursuit of a particular substance despite negative consequences. Although the orbitofrontal cortex (OFC) is known to regulate risk-taking more generally and be critic...