Craving dynamics and related cerebral substrates predict timing of use in alcohol, tobacco, and cannabis use disorders [0.03%]
酒精，烟草和大麻使用综合症中对物质的渴求动态及其大脑皮层相关机理能够预测使用者的使用时间。
Valentine Chirokoff,Maud Dupuy,Majd Abdallah et al.
Valentine Chirokoff et al.
Background: Patients treated for Substance Use Disorders exhibit highly fluctuating patterns of craving that could reveal novel prognostic markers of use. Accordingly, we 1) measured fluctuations within intensively repeat...
Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings [0.03%]
性别差异在环境丰富化对食物限制诱导的可卡因条件性位置偏好持久性的影响及其机制基础中的作用
Sydney P Weiner,Carolina Vasquez,Soomin Song et al.
Sydney P Weiner et al.
Psychosocial and environmental factors, including loss of natural reward, contribute to the risk of drug abuse. Reward loss has been modeled in animals by removal from social or sexual contact, transfer from enriched to impoverished housing...
Low frequency deep brain stimulation of nucleus accumbens shell neuronal subpopulations attenuates cocaine seeking selectively in male rats [0.03%]
低频深脑刺激选择性减弱雄性大鼠的可卡因寻求行为
Sarah E Swinford-Jackson,Matthew T Rich,Phillip J Huffman et al.
Sarah E Swinford-Jackson et al.
The present study examined the effect of deep brain stimulation (DBS) in the nucleus accumbens shell on cocaine seeking and neuronal plasticity in rats. Electrical DBS of the accumbens shell attenuated cocaine primed reinstatement across a ...
Chronic oral methylphenidate plus fluoxetine treatment in adolescent rats increases cocaine self-administration [0.03%]
大鼠青春期长期服用口服右苯丙胺加氟西汀可增加可卡因自给量
Daniela Senior,Madison McCarthy,Rania Ahmed et al.
Daniela Senior et al.
Background: Depression and attention deficit hyperactivity disorder are known to be comorbid. Treatment of these commonly coexisting diseases typically involves the combined prescription of methylphenidate (MP), a psychos...
Fluoxetine potentiates methylphenidate-induced behavioral responses: Enhanced locomotion or stereotypies and facilitated acquisition of cocaine self-administration [0.03%]
氟西汀增强甲基苯丙胺诱导的行为反应：增强运动或刻板行为和促进可卡因自我给药的获得
Lorissa Lamoureux,Joel A Beverley,Michela Marinelli et al.
Lorissa Lamoureux et al.
The medical psychostimulant methylphenidate (MP) is used to treat attention-deficit hyperactivity disorder and recreationally as a "cognitive enhancer". MP is a dopamine reuptake inhibitor, but does not affect serotonin. Serotonin contribut...
Inefficacy of N-acetylcysteine in mitigating cue-induced amphetamine-seeking [0.03%]
N-乙酰半胱氨酸在减轻刺激诱导的安非他命渴求中的无效性
Troy D Fort,Mary E Cain
Troy D Fort
Glutamatergic imbalances are characteristic of SUDs. Astrocytic and neuronal transporters help regulate glutamate homeostasis and disruptions in this homeostasis engender SUD. The cysteine-glutamate exchanger (xCT) is primarily localized on...
Sexually dimorphic effects of a modified adolescent social isolation paradigm on behavioral risk factors of alcohol use disorder in Long Evans Rats [0.03%]
青春期社会隔离范式改变对Long Evans大鼠酒精使用障碍行为风险因素的性别二态影响
Olivia A Ortelli,Stacy R Pitcairn,Christina H Dyson et al.
Olivia A Ortelli et al.
Early life stress (ELS) is a major risk factor for alcohol use disorder (AUD) and comorbid neuropsychiatric conditions. We previously demonstrated that an adolescent social isolation (aSI) model of ELS significantly increased behavioral ris...
Adolescent alcohol disrupts development of noradrenergic neurons in the nucleus of the tractus solitarius and enhances stress behaviors in adulthood in mice in a sex specific manner [0.03%]
青春期酒精会以性别特异性方式干扰孤束核中去甲肾上腺素神经元的发育，并增加成年小鼠的压力行为
Liz A Aguilar,Caitlin R Coker,Zari McCullers et al.
Liz A Aguilar et al.
Alcohol use disorders (AUDs) are common mental health issues worldwide and can lead to other chronic diseases. Stress is a major factor in the development and continuation of AUDs, and adolescent alcohol exposure can lead to enhanced stress...
Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use [0.03%]
雌二醇和μ阿片受体介导的奖赏：雌激素受体在阿片类药物使用中的作用
Sarah B Ethridge,Mark A Smith
Sarah B Ethridge
Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals. This review focuses on the role of ovaria...
Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder [0.03%]
酒精使用障碍小鼠模型前额皮层的谷氨酸能适应性变化
Mahum T Siddiqi,Dhruba Podder,Amanda R Pahng et al.
Mahum T Siddiqi et al.
Alcohol use disorder (AUD) produces cognitive deficits, indicating a shift in prefrontal cortex (PFC) function. PFC glutamate neurotransmission is mostly mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic rece...