The estrous cycle has no effect on incubation of methamphetamine craving and associated Fos expression in dorsomedial striatum and anterior intralaminar nucleus of thalamus [0.03%]
发情周期不影响甲基苯丙胺渴求的诱发及其在背内侧纹状体和丘脑前中间核中c-fos表达
Hongyu Lin,Adedayo Olaniran,Sara Garmchi et al.
Hongyu Lin et al.
Relapse is a major challenge in treating drug addiction, and drug seeking progressively increases after abstinence, a phenomenon termed "incubation of drug craving". Previous studies demonstrated both sex differences and an effect of estrou...
Behavioral and neuronal extracellular vesicle biomarkers associated with nicotine's enhancement of the reinforcing strength of cocaine in female and male monkeys [0.03%]
与尼古丁增强雌雄猴可卡因强化作用相关的行为和神经元胞外囊泡生物标志物
Mia I Allen,Bernard N Johnson,Ashish Kumar et al.
Mia I Allen et al.
While the majority of people with cocaine use disorders (CUD) also co-use tobacco/nicotine, most preclinical cocaine research does not include nicotine. The present study examined nicotine and cocaine co-use under several conditions of intr...
Adolescent nicotine exposure promotes adulthood opioid consumption that persists despite adverse consequences and increases the density of insular perineuronal nets [0.03%]
青春期尼古丁暴露会促进成年期阿片类药物的消耗，并增加岛叶网周神经节密度
S C Honeycutt,A Mukherjee,M S Paladino et al.
S C Honeycutt et al.
Adolescence marks a sensitive period for neurodevelopment wherein exposure to drugs of abuse may disrupt maturation and induce persistent changes in neurophysiology which may exacerbate the risk for developing substance use disorders in adu...
Punishment resistance for cocaine is associated with inflexible habits in rats [0.03%]
与可卡因抗惩罚性相关的实验大鼠习惯的僵化性
Bradley O Jones,Morgan S Paladino,Adelis M Cruz et al.
Bradley O Jones et al.
Addiction is characterized by continued drug use despite negative consequences. In an animal model, a subset of rats continues to self-administer cocaine despite footshock consequences, showing punishment resistance. We sought to test the h...
Brain stimulation therapeutics [0.03%]
脑刺激治疗学
Xingbao Li,Mark S George,Abraham Zangen
Xingbao Li
This chapter covers how repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) presently affects smoking cessation. 14 human studies have examined the efficacy of rTMS on cue craving, cigarette...
Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking [0.03%]
利用舔舐计量法在类似强迫症的饮酒过程中推断敏感性网络区域的不同贡献作用
Phillip A Starski,Thatiane De Oliveira Sergio,Frederic W Hopf
Phillip A Starski
Alcohol use disorder extracts substantial personal, social and clinical costs, and continued intake despite negative consequences (compulsion-like consumption) can contribute strongly. Here we discuss lickometry, a simple method where lick ...
Examining a punishment-related brain circuit with miniature fluorescence microscopes and deep learning [0.03%]
基于纤细型荧光显微镜和深度学习的惩罚相关脑环路研究
Matthew C Broomer,Nicholas J Beacher,Michael W Wang et al.
Matthew C Broomer et al.
In humans experiencing substance use disorder (SUD), abstinence from drug use is often motivated by a desire to avoid some undesirable consequence of further use: health effects, legal ramifications, etc. This process can be experimentally ...
Smoking cessation, harm reduction, and biomarkers protocols in the PhenX Toolkit: Tools for standardized data collection [0.03%]
在PhenX工具包中用于标准数据收集的戒烟、降低危害以及生物标志物的方案
Laura Jean Bierut,Tabitha P Hendershot,Neal L Benowitz et al.
Laura Jean Bierut et al.
The use of standard protocols in studies supports consistent data collection, improves data quality, and facilitates cross-study analyses. Funded by the National Institutes of Health, the PhenX (consensus measures for Phenotypes and eXposur...
The utility of a latent-cause framework for understanding addiction phenomena [0.03%]
潜在原因框架在成瘾现象理解中的作用
Sashank Pisupati,Angela Langdon,Anna B Konova et al.
Sashank Pisupati et al.
Computational models of addiction often rely on a model-free reinforcement learning (RL) formulation, owing to the close associations between model-free RL, habitual behavior and the dopaminergic system. However, such formulations typically...
Craving dynamics and related cerebral substrates predict timing of use in alcohol, tobacco, and cannabis use disorders [0.03%]
酒精，烟草和大麻使用综合症中对物质的渴求动态及其大脑皮层相关机理能够预测使用者的使用时间。
Valentine Chirokoff,Maud Dupuy,Majd Abdallah et al.
Valentine Chirokoff et al.
Background: Patients treated for Substance Use Disorders exhibit highly fluctuating patterns of craving that could reveal novel prognostic markers of use. Accordingly, we 1) measured fluctuations within intensively repeat...