Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking [0.03%]
利用舔舐计量法在类似强迫症的饮酒过程中推断敏感性网络区域的不同贡献作用
Phillip A Starski,Thatiane De Oliveira Sergio,Frederic W Hopf
Phillip A Starski
Alcohol use disorder extracts substantial personal, social and clinical costs, and continued intake despite negative consequences (compulsion-like consumption) can contribute strongly. Here we discuss lickometry, a simple method where lick ...
Examining a punishment-related brain circuit with miniature fluorescence microscopes and deep learning [0.03%]
基于纤细型荧光显微镜和深度学习的惩罚相关脑环路研究
Matthew C Broomer,Nicholas J Beacher,Michael W Wang et al.
Matthew C Broomer et al.
In humans experiencing substance use disorder (SUD), abstinence from drug use is often motivated by a desire to avoid some undesirable consequence of further use: health effects, legal ramifications, etc. This process can be experimentally ...
Smoking cessation, harm reduction, and biomarkers protocols in the PhenX Toolkit: Tools for standardized data collection [0.03%]
在PhenX工具包中用于标准数据收集的戒烟、降低危害以及生物标志物的方案
Laura Jean Bierut,Tabitha P Hendershot,Neal L Benowitz et al.
Laura Jean Bierut et al.
The use of standard protocols in studies supports consistent data collection, improves data quality, and facilitates cross-study analyses. Funded by the National Institutes of Health, the PhenX (consensus measures for Phenotypes and eXposur...
The utility of a latent-cause framework for understanding addiction phenomena [0.03%]
潜在原因框架在成瘾现象理解中的作用
Sashank Pisupati,Angela Langdon,Anna B Konova et al.
Sashank Pisupati et al.
Computational models of addiction often rely on a model-free reinforcement learning (RL) formulation, owing to the close associations between model-free RL, habitual behavior and the dopaminergic system. However, such formulations typically...
Craving dynamics and related cerebral substrates predict timing of use in alcohol, tobacco, and cannabis use disorders [0.03%]
酒精，烟草和大麻使用综合症中对物质的渴求动态及其大脑皮层相关机理能够预测使用者的使用时间。
Valentine Chirokoff,Maud Dupuy,Majd Abdallah et al.
Valentine Chirokoff et al.
Background: Patients treated for Substance Use Disorders exhibit highly fluctuating patterns of craving that could reveal novel prognostic markers of use. Accordingly, we 1) measured fluctuations within intensively repeat...
Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings [0.03%]
性别差异在环境丰富化对食物限制诱导的可卡因条件性位置偏好持久性的影响及其机制基础中的作用
Sydney P Weiner,Carolina Vasquez,Soomin Song et al.
Sydney P Weiner et al.
Psychosocial and environmental factors, including loss of natural reward, contribute to the risk of drug abuse. Reward loss has been modeled in animals by removal from social or sexual contact, transfer from enriched to impoverished housing...
Low frequency deep brain stimulation of nucleus accumbens shell neuronal subpopulations attenuates cocaine seeking selectively in male rats [0.03%]
低频深脑刺激选择性减弱雄性大鼠的可卡因寻求行为
Sarah E Swinford-Jackson,Matthew T Rich,Phillip J Huffman et al.
Sarah E Swinford-Jackson et al.
The present study examined the effect of deep brain stimulation (DBS) in the nucleus accumbens shell on cocaine seeking and neuronal plasticity in rats. Electrical DBS of the accumbens shell attenuated cocaine primed reinstatement across a ...
Chronic oral methylphenidate plus fluoxetine treatment in adolescent rats increases cocaine self-administration [0.03%]
大鼠青春期长期服用口服右苯丙胺加氟西汀可增加可卡因自给量
Daniela Senior,Madison McCarthy,Rania Ahmed et al.
Daniela Senior et al.
Background: Depression and attention deficit hyperactivity disorder are known to be comorbid. Treatment of these commonly coexisting diseases typically involves the combined prescription of methylphenidate (MP), a psychos...
Fluoxetine potentiates methylphenidate-induced behavioral responses: Enhanced locomotion or stereotypies and facilitated acquisition of cocaine self-administration [0.03%]
氟西汀增强甲基苯丙胺诱导的行为反应：增强运动或刻板行为和促进可卡因自我给药的获得
Lorissa Lamoureux,Joel A Beverley,Michela Marinelli et al.
Lorissa Lamoureux et al.
The medical psychostimulant methylphenidate (MP) is used to treat attention-deficit hyperactivity disorder and recreationally as a "cognitive enhancer". MP is a dopamine reuptake inhibitor, but does not affect serotonin. Serotonin contribut...
Inefficacy of N-acetylcysteine in mitigating cue-induced amphetamine-seeking [0.03%]
N-乙酰半胱氨酸在减轻刺激诱导的安非他命渴求中的无效性
Troy D Fort,Mary E Cain
Troy D Fort
Glutamatergic imbalances are characteristic of SUDs. Astrocytic and neuronal transporters help regulate glutamate homeostasis and disruptions in this homeostasis engender SUD. The cysteine-glutamate exchanger (xCT) is primarily localized on...