Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice [0.03%]
口服芬太尼消耗和戒断会损害小鼠尤其是雄性小鼠的恐惧消退学习并增强基底外侧杏仁核主神经元兴奋-抑制平衡
Anthony M Downs,Gracianne Kmiec,Zoé A McElligott
Anthony M Downs
The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the un-regulated drug supply. Over the last few years, ch...
Dopamine D2 receptors in the bed nucleus of the stria terminalis modulate alcohol-related behaviors [0.03%]
伏隔核终纹床核多巴胺D2受体在酒精相关行为中的作用机制研究
Dipanwita Pati,Lisa R Taxier,Mengfan Xia et al.
Dipanwita Pati et al.
Dysregulation of the dopamine (DA) system is a hallmark of substance use disorders, including alcohol use disorder (AUD). Of the DA receptor subtypes, the DA D2 receptors (D2Rs) play a key role in the reinforcing effects of alcohol. D2Rs ar...
Perirhinal cortex to the nucleus accumbens circuit in novelty salience following methamphetamine self-administration [0.03%]
甲胺菲他施用后的新颖性敏感性的边缘回至伏隔核神经环路
Katharine H Nelson,Dylan L Freels,Jordan S Carter et al.
Katharine H Nelson et al.
Methamphetamine (meth) use disorder is part of an overarching use disorder that encompasses continued drug seeking and an increased risk of returning to drug use following periods of abstaining. Chronic meth use results in drug-induced cort...
Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition [0.03%]
伏核抑制破坏巴甫洛夫条件刺激诱导的寻酒行为
Jocelyn M Richard,Bailey Newell,Preethi Muruganandan et al.
Jocelyn M Richard et al.
Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, it...
Melissa C Knouse,Alyssa R Kniffin,Erin A English et al.
Melissa C Knouse et al.
Opioid use disorder involves disruptions to glutamate homeostasis and dendritic spine density in the reward system. PKMζ is an atypical isoform of protein kinase C that is expressed exclusively in neurons and plays a role in postsynaptic g...
Stimulating the posterior parietal cortex reduces self-reported risk-taking propensity in people with tobacco use disorder [0.03%]
刺激顶叶皮层可降低烟草使用障碍患者的自我风险倾向
Francesca M LoFaro,Timothy Jordan,Michael R Apostol et al.
Francesca M LoFaro et al.
Previous research has identified a replicable role for the posterior parietal cortex (PPC) in risk behaviors, but it is unclear whether this relationship is causal. Here, we used a targeted neuromodulation protocol leveraging a single-sessi...
Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism [0.03%]
塞洛昔布在κ型阿片受体处起激动剂的作用且表现出对阿片抗性药物的反应具有性别差异性
Madigan L Bedard,Xi-Ping Huang,Jackson G Murray et al.
Madigan L Bedard et al.
Xylazine is in the unregulated drug supply at increasing rates, usually combined with fentanyl, necessitating understanding of its pharmacology. Despite commentary from politicians, and public health officials, it is unknown how xylazine im...
Changes in dorsomedial striatum activity during expression of goal-directed vs. habit-like cue-induced cocaine seeking [0.03%]
在寻求可卡因过程中，伏隔核背内侧区域活性的变化
Brooke N Bender,Sierra J Stringfield,Mary M Torregrossa
Brooke N Bender
A preclinical model of cue exposure therapy, cue extinction, reduces cue-induced cocaine seeking that is goal-directed but not habit-like. Goal-directed and habitual behaviors differentially rely on the dorsomedial striatum (DMS) and dorsol...
Chst9 marks a spatially and transcriptionally unique population of Oprm1-expressing neurons in the nucleus accumbens [0.03%]
Chst9标记出位于伏隔核中的一群表达Oprm1且在空间分布和转录上独特的神经元族群
Emma Andraka,Robert A Phillips rd,Kasey L Brida et al.
Emma Andraka et al.
Opioids produce addictive, analgesic, and euphoric effects via actions at mu opioid receptors (μORs). The μOR is encoded by the Oprm1 gene and is expressed in multiple brain regions that regulate reward and motivation, such as the nucleus...
Mesocorticolimbic system reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: A pilot fMRI study [0.03%]
酒精敏感表型个体对酒精使用相关视觉线索的大脑边缘系统反应性的一项功能磁共振成像试点研究
Roberto U Cofresí,Spencer Upton,Alexander A Brown et al.
Roberto U Cofresí et al.
Low sensitivity (LS) to alcohol is a risk factor for alcohol use disorder (AUD). Compared to peers with high sensitivity (HS), LS individuals drink more, report more problems, and exhibit potentiated alcohol cue reactivity (ACR). Heightened...