Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta [0.03%]
腹侧被盖区和紧实黑质中神经递质定义的细胞类型的比例和分布
William S Conrad,Lucie Oriol,Grace J Kollman et al.
William S Conrad et al.
Most studies on the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) have focused on dopamine neurons and their role in processes such as motivation, learning, movement, and associated disorders such as addiction and Pa...
Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models [0.03%]
小鼠和大鼠的多种模型中，自愿性青少年酒精暴露不会显著增加成年期的酒精摄入量
Avery R Sicher,Andrea Liss,Valentina Vozella et al.
Avery R Sicher et al.
Adolescence is a period of increased risk taking, including increased alcohol and drug use. Multiple clinical studies report a positive relationship between adolescent alcohol consumption and risk of developing an alcohol use disorder (AUD)...
Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats [0.03%]
评估蔗糖的同时可用性对雄性和雌性Long Evans大鼠的操作性酒精自我给药的影响
Olivia A Ortelli,Jeffrey L Weiner
Olivia A Ortelli
Investigating how environmental factors, such as the availability of non-ethanol alternative reinforcers, influences ethanol self-administration is critical for understanding the pathology of alcohol use disorder (AUD). Here we established ...
Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review [0.03%]
维生素D在预防和治疗冲动控制障碍、行为成瘾和物质使用障碍中的潜在作用：范围审查
Laya Jalilian-Khave,Razi Kitaneh,Binah Baht Ysrayl et al.
Laya Jalilian-Khave et al.
Vitamin D deficiency is a problem of endemic proportions. Vitamin D is a major regulator of dopaminergic and serotonergic circuits, pathways implicated in addictive disorders. This scoping review (OSF registered as 67yhb) examines preclinic...
Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice [0.03%]
纹状体中神经激肽1受体影响小鼠的社会挫败应激敏感性和应激诱导的酒精消耗
Matthew G Solomon,Sadie E Nennig,Mallory R Cotton et al.
Matthew G Solomon et al.
Chronic social defeat stress (SDS) is a widely employed preclinical model of depression involving repeated exposure to physical defeats using a resident-intruder model in male mice. Exposure to SDS induces depressive-like phenotypes includi...
Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice [0.03%]
口服芬太尼消耗和戒断会损害小鼠尤其是雄性小鼠的恐惧消退学习并增强基底外侧杏仁核主神经元兴奋-抑制平衡
Anthony M Downs,Gracianne Kmiec,Zoé A McElligott
Anthony M Downs
The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the un-regulated drug supply. Over the last few years, ch...
Dopamine D2 receptors in the bed nucleus of the stria terminalis modulate alcohol-related behaviors [0.03%]
伏隔核终纹床核多巴胺D2受体在酒精相关行为中的作用机制研究
Dipanwita Pati,Lisa R Taxier,Mengfan Xia et al.
Dipanwita Pati et al.
Dysregulation of the dopamine (DA) system is a hallmark of substance use disorders, including alcohol use disorder (AUD). Of the DA receptor subtypes, the DA D2 receptors (D2Rs) play a key role in the reinforcing effects of alcohol. D2Rs ar...
Perirhinal cortex to the nucleus accumbens circuit in novelty salience following methamphetamine self-administration [0.03%]
甲胺菲他施用后的新颖性敏感性的边缘回至伏隔核神经环路
Katharine H Nelson,Dylan L Freels,Jordan S Carter et al.
Katharine H Nelson et al.
Methamphetamine (meth) use disorder is part of an overarching use disorder that encompasses continued drug seeking and an increased risk of returning to drug use following periods of abstaining. Chronic meth use results in drug-induced cort...
Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition [0.03%]
伏核抑制破坏巴甫洛夫条件刺激诱导的寻酒行为
Jocelyn M Richard,Bailey Newell,Preethi Muruganandan et al.
Jocelyn M Richard et al.
Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, it...
Melissa C Knouse,Alyssa R Kniffin,Erin A English et al.
Melissa C Knouse et al.
Opioid use disorder involves disruptions to glutamate homeostasis and dendritic spine density in the reward system. PKMζ is an atypical isoform of protein kinase C that is expressed exclusively in neurons and plays a role in postsynaptic g...