Amy S Kohtz,Hannah Davies,Belle Lin et al.
Amy S Kohtz et al.
There are substantial sex differences in substance use disorders (SUDs), and a key feature of SUD is pathologically high economic demand for drug. The hypothalamic neuropeptide oxytocin (OXT) is heavily implicated in the modern treatment of...
Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle [0.03%]
芬太尼在雌鼠中的需求和寻求：下丘脑泌素系统及动情周期的作用
David De Sa Nogueira,Chuhyon Corwin,Yogesh Rakholia et al.
David De Sa Nogueira et al.
The orexin system plays a major role in drug reward. Orexin-1 receptor (OxR1) blockade reduces fentanyl demand in males. However, there are a number of sex differences in the orexin system, and it is unclear how OxR1 antagonism would decrea...
Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in rats [0.03%]
来自捕食者气味的压力对雄性和雌性大鼠恐惧、类似焦虑的行为和甲基苯丙胺觅药的性别特异性影响
Modrak Cg,Wilkinson Cs,Claypool Ad et al.
Modrak Cg et al.
Methamphetamine use disorder (MUD) is frequently comorbid with other disorders, such as post-traumatic stress disorder (PTSD). Here, we used a rat model of PTSD+MUD to evaluate the influence of sex and stress on methamphetamine-seeking and ...
EcoHIV infection effects on cocaine seeking and neuroimmune responses in male mice depend on cocaine exposure pattern [0.03%]
模式依赖的小鼠可卡因觅药行为及生态型HIV感染引起的神经免疫反应改变
Mark D Namba,Qiaowei Xie,Kyewon Park et al.
Mark D Namba et al.
Cocaine use disorders (CUDs) and human immunodeficiency virus (HIV) remain persistent public health dilemmas throughout the world. Cocaine seeking increases over a protracted period of abstinence, an effect known as the incubation of cravin...
Methamphetamine produces behavioral flexibility deficits that are attenuated by COX-2 inhibition in both male and female rats [0.03%]
甲基苯丙胺可在雌雄大鼠中诱发行为灵活性下降，且该现象可被COX-2抑制所缓解
Amanda M Acuña,Serena E Rodarte,Skylar Bickley et al.
Amanda M Acuña et al.
Methamphetamine (METH) Use Disorder (MUD) and METH-related overdose deaths continue to rise in the United States and elsewhere. Patients with MUD experience cognitive inflexibility, which conveys a vulnerability to continued addictive behav...
Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta [0.03%]
腹侧被盖区和紧实黑质中神经递质定义的细胞类型的比例和分布
William S Conrad,Lucie Oriol,Grace J Kollman et al.
William S Conrad et al.
Most studies on the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) have focused on dopamine neurons and their role in processes such as motivation, learning, movement, and associated disorders such as addiction and Pa...
Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models [0.03%]
小鼠和大鼠的多种模型中，自愿性青少年酒精暴露不会显著增加成年期的酒精摄入量
Avery R Sicher,Andrea Liss,Valentina Vozella et al.
Avery R Sicher et al.
Adolescence is a period of increased risk taking, including increased alcohol and drug use. Multiple clinical studies report a positive relationship between adolescent alcohol consumption and risk of developing an alcohol use disorder (AUD)...
Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats [0.03%]
评估蔗糖的同时可用性对雄性和雌性Long Evans大鼠的操作性酒精自我给药的影响
Olivia A Ortelli,Jeffrey L Weiner
Olivia A Ortelli
Investigating how environmental factors, such as the availability of non-ethanol alternative reinforcers, influences ethanol self-administration is critical for understanding the pathology of alcohol use disorder (AUD). Here we established ...
Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review [0.03%]
维生素D在预防和治疗冲动控制障碍、行为成瘾和物质使用障碍中的潜在作用：范围审查
Laya Jalilian-Khave,Razi Kitaneh,Binah Baht Ysrayl et al.
Laya Jalilian-Khave et al.
Vitamin D deficiency is a problem of endemic proportions. Vitamin D is a major regulator of dopaminergic and serotonergic circuits, pathways implicated in addictive disorders. This scoping review (OSF registered as 67yhb) examines preclinic...
Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice [0.03%]
纹状体中神经激肽1受体影响小鼠的社会挫败应激敏感性和应激诱导的酒精消耗
Matthew G Solomon,Sadie E Nennig,Mallory R Cotton et al.
Matthew G Solomon et al.
Chronic social defeat stress (SDS) is a widely employed preclinical model of depression involving repeated exposure to physical defeats using a resident-intruder model in male mice. Exposure to SDS induces depressive-like phenotypes includi...