The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol [0.03%]
暴露于捕食者气味应激对酒精敏感性的影响
Ryan E Tyler,Maya N Bluitt,Kalynn J Van Voorhies et al.
Ryan E Tyler et al.
Traumatic stress is linked to problematic alcohol use, yet its persistent effects on alcohol sensitivity remain unclear. This study examined the long-term effects of traumatic stress on alcohol sensitivity in male and female Long-Evans rats...
The acoustic properties, syllable structure, and syllable sequences of ultrasonic vocalizations (USVs) during neonatal opioid withdrawal in FVB/N mouse substrains [0.03%]
FVB/N子系小鼠围产期阿片类药物戒断期间超声波发声（USV）的声学特性、音节结构和音节序列
Kelly K Wingfield,Teodora Misic,Sophia A Miracle et al.
Kelly K Wingfield et al.
Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents [0.03%]
神经紧张素受体1偏置变构调节剂可减少啮齿类动物的酒精摄入和对酒精给药的反应
Graydon B Gereau,Diana Zhou,Kalynn Van Voorhies et al.
Graydon B Gereau et al.
Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7th leading cause of premature death [1]. Despite this, there are currently only 3 FDA approved pharmacological approaches ...
Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration [0.03%]
利用微型光学和深度学习比较精神刺激剂和阿片类药物自我给药的神经行为表征
Matthew C Broomer,Caroline E Clark,Jan Shanelle J Iringan et al.
Matthew C Broomer et al.
Concurrent abuse of psychostimulants and opioids represents a growing public health concern. However, preclinical models of substance use disorder often situate psychostimulants and opioids similarly within a unified self-administration pro...
Genomic and Behavioral Signatures of Selection for Ethanol Preference from the Heterogeneous Stock Collaborative Cross Mice - The Central Nucleus of the Amygdala [0.03%]
基因和行为的选择标志来自异质种群协作杂交小鼠的乙醇偏好-杏仁体中心核
Justin Q Anderson,Priscila Darakjian,Robert Hitzemann et al.
Justin Q Anderson et al.
Alcohol use disorder (AUD) is a complex disease with heritability of ~0.5, indicating genetic and non-genetic factors contribute to risk. Identifying gene expression networks contributing to risk using post-mortem human brain tissue has the...
Amy S Kohtz,Hannah Davies,Belle Lin et al.
Amy S Kohtz et al.
There are substantial sex differences in substance use disorders (SUDs), and a key feature of SUD is pathologically high economic demand for drug. The hypothalamic neuropeptide oxytocin (OXT) is heavily implicated in the modern treatment of...
Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle [0.03%]
芬太尼在雌鼠中的需求和寻求：下丘脑泌素系统及动情周期的作用
David De Sa Nogueira,Chuhyon Corwin,Yogesh Rakholia et al.
David De Sa Nogueira et al.
The orexin system plays a major role in drug reward. Orexin-1 receptor (OxR1) blockade reduces fentanyl demand in males. However, there are a number of sex differences in the orexin system, and it is unclear how OxR1 antagonism would decrea...
Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in rats [0.03%]
来自捕食者气味的压力对雄性和雌性大鼠恐惧、类似焦虑的行为和甲基苯丙胺觅药的性别特异性影响
Modrak Cg,Wilkinson Cs,Claypool Ad et al.
Modrak Cg et al.
Methamphetamine use disorder (MUD) is frequently comorbid with other disorders, such as post-traumatic stress disorder (PTSD). Here, we used a rat model of PTSD+MUD to evaluate the influence of sex and stress on methamphetamine-seeking and ...
EcoHIV infection effects on cocaine seeking and neuroimmune responses in male mice depend on cocaine exposure pattern [0.03%]
模式依赖的小鼠可卡因觅药行为及生态型HIV感染引起的神经免疫反应改变
Mark D Namba,Qiaowei Xie,Kyewon Park et al.
Mark D Namba et al.
Cocaine use disorders (CUDs) and human immunodeficiency virus (HIV) remain persistent public health dilemmas throughout the world. Cocaine seeking increases over a protracted period of abstinence, an effect known as the incubation of cravin...
Methamphetamine produces behavioral flexibility deficits that are attenuated by COX-2 inhibition in both male and female rats [0.03%]
甲基苯丙胺可在雌雄大鼠中诱发行为灵活性下降，且该现象可被COX-2抑制所缓解
Amanda M Acuña,Serena E Rodarte,Skylar Bickley et al.
Amanda M Acuña et al.
Methamphetamine (METH) Use Disorder (MUD) and METH-related overdose deaths continue to rise in the United States and elsewhere. Patients with MUD experience cognitive inflexibility, which conveys a vulnerability to continued addictive behav...