Parvalbumin expression does not account for discrete electrophysiological profiles of glutamatergic ventral pallidal subpopulations [0.03%]
钙调蛋白表达不能解释谷氨酸能腹苍白球亚群的电生理特征差异
Robert D Graham,Lisa Z Fang,Jessica R Tooley et al.
Robert D Graham et al.
The ventral pallidum (VP) has emerged as a critical node in the mesolimbic reward system. Modulating the VP can impact the subjective valuation of rewards, reward motivation, and reward seeking under conflict, making it an attractive target...
Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice [0.03%]
内源性G蛋白信号调节因子14通过削弱引起情绪动机行为的作用来抑制雌性小鼠的可卡因成瘾作用
Sara N Bramlett,Stephanie L Foster,David Weinshenker et al.
Sara N Bramlett et al.
Addictive drugs hijack the neuronal mechanisms of learning and memory in motivation and emotion processing circuits to reinforce their own use. Regulator of G-protein Signaling 14 (RGS14) is a natural suppressor of post-synaptic plasticity ...
Methadone and morphine have equivalent analgesic but not reward potency in female mice [0.03%]
美沙酮和吗啡具有等效的镇痛作用但不具有等效的欣快作用：雌性小鼠模型研究
Akash Shanmugam,Samantha O Vanderhoof,Michael A Kelberman et al.
Akash Shanmugam et al.
Background: Morphine is a potent opioid analgesic but carries high abuse potential. Some evidence indicates that the opioid methadone, used in maintenance therapy for opioid dependence, also provides analgesia with lower ...
Fos expression in the periaqueductal gray, but not the ventromedial hypothalamus, is correlated with psychosocial stress-induced cocaine-seeking behavior in rats [0.03%]
纹状体外侧区而非室旁核的c-fos表达与应激诱发的可卡因求取行为相关性研究
Nicole M Hinds,Ireneusz D Wojtas,Desta M Pulley et al.
Nicole M Hinds et al.
Psychosocial stressors are known to promote cocaine craving and relapse in humans but are infrequently employed in preclinical relapse models. Consequently, the underlying neural circuitry by which these stressors drive cocaine seeking has ...
Opioid drug seeking after early-life adversity: a role for delta opioid receptors [0.03%]
早期生活逆境后的阿片类药物寻求作用：δ型阿片受体的作用
Sophia C Levis,Matthew T Birnie,Yiyan Xie et al.
Sophia C Levis et al.
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in fem...
The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol [0.03%]
暴露于捕食者气味应激对酒精敏感性的影响
Ryan E Tyler,Maya N Bluitt,Kalynn J Van Voorhies et al.
Ryan E Tyler et al.
Traumatic stress is linked to problematic alcohol use, yet its persistent effects on alcohol sensitivity remain unclear. This study examined the long-term effects of traumatic stress on alcohol sensitivity in male and female Long-Evans rats...
The acoustic properties, syllable structure, and syllable sequences of ultrasonic vocalizations (USVs) during neonatal opioid withdrawal in FVB/N mouse substrains [0.03%]
FVB/N子系小鼠围产期阿片类药物戒断期间超声波发声（USV）的声学特性、音节结构和音节序列
Kelly K Wingfield,Teodora Misic,Sophia A Miracle et al.
Kelly K Wingfield et al.
Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents [0.03%]
神经紧张素受体1偏置变构调节剂可减少啮齿类动物的酒精摄入和对酒精给药的反应
Graydon B Gereau,Diana Zhou,Kalynn Van Voorhies et al.
Graydon B Gereau et al.
Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7th leading cause of premature death [1]. Despite this, there are currently only 3 FDA approved pharmacological approaches ...
Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration [0.03%]
利用微型光学和深度学习比较精神刺激剂和阿片类药物自我给药的神经行为表征
Matthew C Broomer,Caroline E Clark,Jan Shanelle J Iringan et al.
Matthew C Broomer et al.
Concurrent abuse of psychostimulants and opioids represents a growing public health concern. However, preclinical models of substance use disorder often situate psychostimulants and opioids similarly within a unified self-administration pro...
Genomic and Behavioral Signatures of Selection for Ethanol Preference from the Heterogeneous Stock Collaborative Cross Mice - The Central Nucleus of the Amygdala [0.03%]
基因和行为的选择标志来自异质种群协作杂交小鼠的乙醇偏好-杏仁体中心核
Justin Q Anderson,Priscila Darakjian,Robert Hitzemann et al.
Justin Q Anderson et al.
Alcohol use disorder (AUD) is a complex disease with heritability of ~0.5, indicating genetic and non-genetic factors contribute to risk. Identifying gene expression networks contributing to risk using post-mortem human brain tissue has the...