Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner [0.03%]
酒精戒断通过一种抑制性神经元和性别特异性方式改变腹侧前扣带回皮层的抑制性格局
Sema G Quadir,S Danyal Zaidi,Meredith G Cone et al.
Sema G Quadir et al.
Alcohol use disorder (AUD) is highly prevalent and associated with substantial morbidity and mortality. While there are currently three FDA-approved medications for AUD, none specifically target the withdrawal/negative affect stage of AUD, ...
Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats [0.03%]
异质种系大鼠下丘脑视交叉上核中长期奥施康定给药后持续存在的性别特异性转录标志在戒断和不使用药物期间的出现
Tara C Delorme,Snehal Sambare,Benjamin R Williams et al.
Tara C Delorme et al.
Opioid use disorder (OUD) is a major public health problem. Sleep and circadian disruptions are recognized as hallmarks of substance use disorders, often emerging during withdrawal and lasting into abstinence. Little is known about the impa...
Presence of distinct operant phenotypes and transient withdrawal-induced escalation of operant ethanol intake in female rats [0.03%]
雌性大鼠中存在不同的操作体征和短暂的戒断诱导的操作性乙醇摄入量增加现象
Joseph R Pitock,Shannon R Wheeler,Arleen Perez Ayala et al.
Joseph R Pitock et al.
Operant self-administration is frequently used to investigate the neurobiological mechanisms underlying alcohol seeking and drinking and to evaluate treatments of alcohol use disorder (AUD). Although widely used by the research community, t...
Sex-dependent hippocampal atrophy among people with methamphetamine-use experience [0.03%]
甲基安非他命使用者海马区性别依赖性萎缩现象研究
Hillary Schwarb,Robert J Roy,Alisha L Schaefer et al.
Hillary Schwarb et al.
As methamphetamine use rates continue to climb, understanding its relationship with physical, mental, and cognitive decline is critical. While memory difficulties are common, the underlying neurobiology of these deficits are not well unders...
Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum [0.03%]
青少年社会隔离与腹侧苍白球中乙醇诱导的多巴胺调节变化有关
Gavin J Vaughan,Makenzie R Lehr,Gina M Magardino et al.
Gavin J Vaughan et al.
Adolescent social isolation (aSI) has been demonstrated to increase anxiety-like behavior and ethanol consumption. The ventral pallidum (VP), a basal ganglia structure that receives dopaminergic projections from the VTA, contributes to rewa...
Parvalbumin expression does not account for discrete electrophysiological profiles of glutamatergic ventral pallidal subpopulations [0.03%]
钙调蛋白表达不能解释谷氨酸能腹苍白球亚群的电生理特征差异
Robert D Graham,Lisa Z Fang,Jessica R Tooley et al.
Robert D Graham et al.
The ventral pallidum (VP) has emerged as a critical node in the mesolimbic reward system. Modulating the VP can impact the subjective valuation of rewards, reward motivation, and reward seeking under conflict, making it an attractive target...
Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice [0.03%]
内源性G蛋白信号调节因子14通过削弱引起情绪动机行为的作用来抑制雌性小鼠的可卡因成瘾作用
Sara N Bramlett,Stephanie L Foster,David Weinshenker et al.
Sara N Bramlett et al.
Addictive drugs hijack the neuronal mechanisms of learning and memory in motivation and emotion processing circuits to reinforce their own use. Regulator of G-protein Signaling 14 (RGS14) is a natural suppressor of post-synaptic plasticity ...
Methadone and morphine have equivalent analgesic but not reward potency in female mice [0.03%]
美沙酮和吗啡具有等效的镇痛作用但不具有等效的欣快作用：雌性小鼠模型研究
Akash Shanmugam,Samantha O Vanderhoof,Michael A Kelberman et al.
Akash Shanmugam et al.
Background: Morphine is a potent opioid analgesic but carries high abuse potential. Some evidence indicates that the opioid methadone, used in maintenance therapy for opioid dependence, also provides analgesia with lower ...
Fos expression in the periaqueductal gray, but not the ventromedial hypothalamus, is correlated with psychosocial stress-induced cocaine-seeking behavior in rats [0.03%]
纹状体外侧区而非室旁核的c-fos表达与应激诱发的可卡因求取行为相关性研究
Nicole M Hinds,Ireneusz D Wojtas,Desta M Pulley et al.
Nicole M Hinds et al.
Psychosocial stressors are known to promote cocaine craving and relapse in humans but are infrequently employed in preclinical relapse models. Consequently, the underlying neural circuitry by which these stressors drive cocaine seeking has ...
Opioid drug seeking after early-life adversity: a role for delta opioid receptors [0.03%]
早期生活逆境后的阿片类药物寻求作用：δ型阿片受体的作用
Sophia C Levis,Matthew T Birnie,Yiyan Xie et al.
Sophia C Levis et al.
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in fem...