Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission [0.03%]
cocaine渴求的诱导与多巴胺末梢神经传导的变化相吻合
I Pamela Alonso,Bethan M O&#x;Connor,Kathleen G Bryant et al.
I Pamela Alonso et al.
Relapse to drug use is one of the major challenges in treating substance use disorders. Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine seeking, and increases the probability of relapse. Clinical and a...
Lateral habenula-projecting central amygdala circuits expressing GABA and NPY Y1 receptor modulate binge-like ethanol intake in mice [0.03%]
表达GABA和NPY Y1受体的中央杏仁核外侧缰核投射环路可调节小鼠乙醇成瘾行为
Michel A Companion,David A Gonzalez,Stacey L Robinson et al.
Michel A Companion et al.
The central nucleus of the amygdala (CeA) is a critical brain region in the integration of emotional behaviors and is one of the major output areas of the amygdaloid complex. The CeA is composed of GABAergic interneurons and projection neur...
The incubation of cocaine craving is dissociated from changes in glial cell markers within prefrontal cortex and nucleus accumbens of rats [0.03%]
Cocaine渴求的形成与前额叶皮质和伏隔核小胶质细胞和星形胶质细胞标志物的变化无关
Sierra M Webb,Arianne D Sacramento,Megan A McCloskey et al.
Sierra M Webb et al.
Activation of the dorsal septum increases alcohol consumption in male C57BL/6J mice [0.03%]
激活背侧隔区可增加C57BL/6J小鼠的酒精摄入量
Harold L Haun,Shannon L D&#x;Ambrosio,Dipanwita Pati et al.
Harold L Haun et al.
Binge drinking is a common pattern of excessive alcohol consumption associated with Alcohol Use Disorder (AUD) and unraveling the neurocircuitry that promotes this type of drinking is critical to the development of novel therapeutic interve...
Neural circuit mechanisms of the cholecystokinin (CCK) neuropeptide system in addiction [0.03%]
胆囊收缩素（CCK）神经肽系统在成瘾中的作用机制
Yihe Ma,William J Giardino
Yihe Ma
Given historical focus on the roles for cholecystokinin (CCK) as a peripheral hormone controlling gastrointestinal processes and a brainstem peptide regulating food intake, the study of CCK as a limbic neuromodulator coordinating reward-see...
Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats [0.03%]
单一和双 hypocretin 受体阻滞或敲低 hypocretin 中央杏仁核投射对依赖型雄性大鼠酒精摄入的影响
Gabriel M Aldridge,Tyler A Zarin,Adam J Brandner et al.
Gabriel M Aldridge et al.
Hypocretin/Orexin (HCRT) is a neuropeptide that is associated with both stress and reward systems in humans and rodents. The different contributions of signaling at hypocretin-receptor 1 (HCRT-R1) and hypocretin-receptor 2 (HCRT-R2) to comp...
Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities [0.03%]
与酒精使用障碍及其共病相关的功能多态性和表观遗传标记的储存库——上下文依赖的增强子
Alasdair MacKenzie,Elizabeth A Hay,Andrew R McEwan
Alasdair MacKenzie
Alcohol use disorder (AUD) is one of the major causes of mortality and morbidity world-wide. It is estimated that 50% of the causes of AUD are heritable. Efforts to determine the genetic determinants governing AUD using genome wide associat...
Challenges and new opportunities for detecting endogenous opioid peptides in reward [0.03%]
奖赏中的内源性鸦片肽检测面临的新挑战和机遇
Sineadh M Conway,Marwa O Mikati,Ream Al-Hasani
Sineadh M Conway
The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing eve...
Novelty preference does not predict trait cocaine behaviors in male rats [0.03%]
新颖性偏好不能预测雄性大鼠的 Cocaine 性格行为
Shayna L O&#x;Connor,Gary Aston-Jones,Morgan H James
Shayna L O&#x;Connor
Heightened novelty seeking is a risk factor for the initiation of drug use and development of substance use disorders. In rats, novelty seeking can be examined by assessing preference for a novel environment. Some evidence indicates that hi...