GRIN lens applications for studying neurobiology of substance use disorder [0.03%]
GRIN透镜在物质使用障碍神经生物学研究中的应用
Nicholas James Beacher,Kayden Alecsandre Washington,Yan Zhang et al.
Nicholas James Beacher et al.
Substance use disorder (SUD) is associated with severe health and social consequences. Continued drug use results in alterations of circuits within the mesolimbic dopamine system. It is critical to observe longitudinal impacts of SUD on neu...
Nora D Volkow,Eric M Wargo
Nora D Volkow
Acute sensitization of the P3 event-related potential response to beverage images and the risk for alcohol use disorder [0.03%]
饮料图像P3事件相关电位反应的急性敏化和酒精使用障碍的风险
Roberto U Cofresí,Thomas M Piasecki,Bruce D Bartholow
Roberto U Cofresí
Previous research suggests the amplitude of the P3 event-related potential (ERP) response reflects the incentive value of the eliciting stimulus, and that individuals with trait-like lower sensitivity (LS) to the acute effects of alcohol, a...
Regulation of glutamate homeostasis in the nucleus accumbens by astrocytic CB1 receptors and its role in cocaine-motivated behaviors [0.03%]
伏核内星形胶质细胞CB1受体对谷氨酸稳态的调节及其在可卡因动机行为中的作用
Lan-Yuan Zhang,Andrew Y Kim,Joseph F Cheer
Lan-Yuan Zhang
Cannabinoid type 1 receptors (CB1Rs) orchestrate brain reward circuitry and are prevalent neurobiological targets for endocannabinoids and cannabis in the mammalian brain. Decades of histological and electrophysiological studies have establ...
The roles of rat medial prefrontal and orbitofrontal cortices in relapse to cocaine-seeking: A comparison across methods for identifying neurocircuits [0.03%]
大鼠前额叶和眶额皮质在可卡因觅药复发中的作用：不同方法识别神经环路的比较
Javier R Mesa,Daniel W Wesson,Marek Schwendt et al.
Javier R Mesa et al.
A large body of research supports the notion that regions of the rodent frontal cortex regulate reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration. However, earlier studies identifying the roles of m...
Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward [0.03%]
光遗传学刺激背缝核中dynorphin能神经元，激活中脑腹侧被盖区多巴胺神经元上的κ阿片受体，并证明破坏背缝核中的 prodynoin 或者多巴胺神经元上的 κ 受体可阻断应激增强可卡因引起的欣快反应
Antony D Abraham,Sanne M Casello,Benjamin B Land et al.
Antony D Abraham et al.
Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR). KOR agonists have b...
Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models [0.03%]
腹苍白球GABA能神经元调控阿片类药物复吸行为
Mitchell R Farrell,Qiying Ye,Yiyan Xie et al.
Mitchell R Farrell et al.
Opioid addiction is a chronic, relapsing disorder. Whether addicted individuals are forced to abstain or they decide themselves to quit using drugs, relapse rates are high-especially upon encountering contexts and stimuli associated with pr...
The subjective experience of heroin effects among individuals with chronic opioid use: Revisiting reinforcement in an exploratory study [0.03%]
慢性阿片类药物使用人群对海洛因作用的主观体验：一项探索性研究中回归强化作用
Suky Martinez,Laura Brandt,Sandra D Comer et al.
Suky Martinez et al.
Aims: Consistent with the opponent process theory individuals with chronic opioid use should predominantly endorse the avoidance of aversive negative emotional and/or physiological states as the motivation for continued o...
Kappa-opioid receptor activation reinstates nicotine self-administration in mice [0.03%]
κ-阿片受体激活可使小鼠复吸尼古丁自我给药行为
Raajaram Gowrishankar,Adrian Gomez,Marie Waliki et al.
Raajaram Gowrishankar et al.
Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission [0.03%]
cocaine渴求的诱导与多巴胺末梢神经传导的变化相吻合
I Pamela Alonso,Bethan M O&#x;Connor,Kathleen G Bryant et al.
I Pamela Alonso et al.
Relapse to drug use is one of the major challenges in treating substance use disorders. Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine seeking, and increases the probability of relapse. Clinical and a...