The Effects of the Inhalant Toluene on Cognitive Function and Behavioral Flexibility: A Review of Recent Findings [0.03%]
(toluen对认知功能和行为灵活性的影响:近期研究综述)
John J Woodward,Kevin M Braunscheidel
John J Woodward
Substance use disorder (SUD) is characterized, in part, by lack of control over drug seeking and taking. The prefrontal cortex (PFC) is highly involved in control of behavior and deficits in PFC structure and function have been demonstrated...
mGlu5 inhibition in the basolateral amygdala prevents estrous cycle-dependent changes in cue-induced cocaine seeking [0.03%]
抑制基底外侧杏仁核中的mGlu5受体可防止动情周期依赖性线索诱发的可卡因觅食行为的变化
Claire M Corbett,Emily N D Miller,Jessica A Loweth
Claire M Corbett
Drug associated cues are a common relapse trigger for individuals recovering from cocaine use disorder. Sex and ovarian hormones influence patterns of cocaine use and relapse vulnerability, with studies indicating that females show increase...
Behavioral phenotypes revealed during reversal learning are linked with novel genetic loci in diversity outbred mice [0.03%]
逆转学习过程中揭示的行为表型与多样性杂交小鼠的新遗传位点相关联
Jared R Bagley,Lauren S Bailey,Leona H Gagnon et al.
Jared R Bagley et al.
Impulsive behavior and impulsivity are heritable phenotypes that are strongly associated with risk for substance use disorders. Identifying the neurogenetic mechanisms that influence impulsivity may also reveal novel biological insights int...
Extended access to fentanyl vapor self-administration leads to addiction-like behaviors in mice: Blood chemokine/cytokine levels as potential biomarkers [0.03%]
延长接触芬太尼蒸汽自我给药小鼠表现出类似成瘾的行为：血液趋化因子/细胞因子水平作为潜在生物标志物
Renata C N Marchette,Erika R Carlson,Nadia Said et al.
Renata C N Marchette et al.
Rodent models are useful for understanding the mechanisms that underlie opioid addiction, but most preclinical studies have focused on rewarding and consummatory aspects of opioids without components of dependence-induced escalation of drug...
Adolescent alcohol exposure reduces dopamine 1 receptor modulation of prelimbic neurons projecting to the nucleus accumbens and basolateral amygdala [0.03%]
青春期酒精暴露减少投射到伏隔核和基底外侧杏仁核的腹外侧前额皮层神经元上的多巴胺1受体调节作用
J Daniel Obray,Justine D Landin,Dylan T Vaughan et al.
J Daniel Obray et al.
Binge drinking during adolescence is highly prevalent despite increasing evidence of its long-term impact on behaviors associated with modulation of behavioral flexibility by the medial prefrontal cortex (mPFC). In the present study, male a...
Adolescent intermittent ethanol exposure reduces astrocyte-synaptic proximity in the adult medial prefrontal cortex in rats: Reversal by gabapentin [0.03%]
青少年期间歇性酒精暴露减少大鼠成年前额叶皮层中星形胶质细胞和突触的接近程度：加巴喷丁使其恢复
Kati L Healey,Amelia Bell,Michael D Scofield et al.
Kati L Healey et al.
Alcohol consumption in adolescence causes multiple acute negative changes in neural and behavioral function that persist well into adulthood and possibly throughout life. The medial prefrontal cortex (mPFC) and dorsal hippocampus are critic...
Circuit dysfunctions of associative and sensorimotor basal ganglia loops in alcohol use disorder: insights from animal models [0.03%]
酒精使用障碍中联想和感觉运动基底节环路的电路功能紊乱：来自动物模型的启示
Giacomo Sitzia,David M Lovinger
Giacomo Sitzia
Persons that develop Alcohol Use Disorder (AUD) experience behavioral changes that include compulsion to seek and take alcohol despite its negative consequences on the person's psychosocial, health and economic spheres, inability to limit a...
Low- and high-cocaine intake affects the spatial and temporal dynamics of class IIa HDAC expression-activity in the nucleus accumbens and hippocampus of male rats as measured by [18F]TFAHA PET/CT neuroimaging [0.03%]
低剂量和高剂量可卡因摄入影响雄性大鼠伏隔核和海马中第二类A组HDAC表达-活性的时空动力学，通过[18F]TFAHA PET/CT神经成像进行测量
Shane A Perrine,Walid F Alsharif,Arman Harutyunyan et al.
Shane A Perrine et al.
Repeated cocaine alters neuronal function in the nucleus accumbens (NAc), a brain region involved in cocaine taking, and in hippocampus (HC), known for contextual and associative learning. [18F]TFAHA is a histone deacetylase (HDAC) class II...
Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice [0.03%]
雌性小鼠应激诱导的奖赏寻求再发生的发情周期和激素调节
Laura L Giacometti,Lauren A Buck,Jacqueline M Barker
Laura L Giacometti
Women are more vulnerable to stress-induced craving, which may be associated with increased vulnerability to relapse. Susceptibility to stress-induced craving also appears to be modulated by the menstrual cycle and is negatively correlated ...
Corticotropin releasing factor and drug seeking in substance use disorders: Preclinical evidence and translational limitations [0.03%]
促肾上腺皮质激素释放因子和物质使用障碍中的觅药行为：临床前证据及转化限制
John R Mantsch
John R Mantsch
The neuropeptide, corticotropin releasing factor (CRF), has been an enigmatic target for the development of medications aimed at treating stress-related disorders. Despite a large body of evidence from preclinical studies in rodents demonst...