Alcohol-drinking during later life by C57BL/6J mice induces sex- and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate receptors and neuropathology markers [0.03%]
成年期饮酒通过C57BL/6J小鼠诱导海马和前额叶皮质中谷氨酸受体及神经病理标志物的性别和年龄依赖性变化
Karen K Szumlinski,Jessica N Herbert,Brenda Mejia Espinoza et al.
Karen K Szumlinski et al.
Heavy drinking can induce early-onset dementia and increase the likelihood of the progression and severity of Alzheimer's Disease and related dementias (ADRD). Recently, we showed that alcohol-drinking by mature adult C57BL/6J mice induces ...
Prelimbic cortex and nucleus accumbens core resting state signaling dynamics as a biomarker for cocaine seeking behaviors [0.03%]
前扣带回皮层和伏隔核核团静息态信号动力学作为可卡因寻购行为生物标志物的研究
Metika L Ngbokoli,Joaquin E Douton,Regina M Carelli
Metika L Ngbokoli
Substance use disorders (SUDs) are characterized by maladaptive signaling in the prefrontal cortex and associated regions, however precisely how these drug-induced abnormalities may be linked to drug seeking/taking behaviors is not well und...
The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke [0.03%]
性激素在针对吸烟女性压力引起的烟草渴望、压力反应和吸烟方面使用胍法辛的作用
MacKenzie R Peltier,Sherry A McKee
MacKenzie R Peltier
Women who smoke are particularly vulnerable to tobacco craving, smoking behaviors, and relapse in the context of stress when compared to men who smoke. One factor in this sex difference may be sex hormones, including estradiol and progester...
No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis [0.03%]
阿片类物质使用者表观遗传学衰老加速的证据不足：病例对照研究
Jermaine D Jones,Suky Martinez,Ingrid Gonzalez et al.
Jermaine D Jones et al.
This study sought to assess the association between illicit opioid use and accelerated epigenetic aging (A.K.A. DNAm Age) among people of African ancestry who use heroin. DNA was obtained from participants with opioid use disorder (OUD) who...
Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration [0.03%]
与海洛因使用增加和纳络酮诱导的海洛因自我给药增加相关的扣带回环路
M J Scarlata,R J Keeley,S A Carmack et al.
M J Scarlata et al.
Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of control over intake and the development of a negative emotional state when access to opioids is denied. Using functional magnetic resonance imaging (fMRI...
Electronic Vaporization of Nicotine Salt or Freebase produces differential effects on metabolism, neuronal activity and behavior in male and female C57BL/6J mice [0.03%]
尼古丁盐或基础电子蒸发对雄性和雌性C57BL/6J小鼠的代谢，神经元活性和行为产生不同的影响
Maria Echeveste Sanchez,ManHua Zhu,Sarah Magee et al.
Maria Echeveste Sanchez et al.
The use of Electronic Nicotine Delivery Systems (ENDS) is increasing in prevalence and popularity. ENDS are a rapidly evolving technology as devices and e-liquid formulations adapt to policy restrictions and market demand To identify the im...
Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards [0.03%]
与摄食有关的肽对中缝多巴胺系统的的作用在自然奖赏和药物奖赏的调节中的作用
Anna I Dunigan,Aaron G Roseberry
Anna I Dunigan
The mesolimbic dopamine system is the primary neural circuit mediating motivation, reinforcement, and reward-related behavior. The activity of this system and multiple behaviors controlled by it are affected by changes in feeding and body w...
Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking [0.03%]
岛叶和前扣带回灰质体积及其在吸烟行为中的作用机制研究
Yu Chen,Shefali Chaudhary,Wuyi Wang et al.
Yu Chen et al.
The salience network, including the insula and anterior cingulate cortex (ACC), has been implicated in nicotine addiction. Structural imaging studies have reported diminished insula and ACC gray matter volumes (GMVs) in smokers as compared ...
Predictors of smoking cessation outcomes identified by machine learning: A systematic review [0.03%]
机器学习识别的吸烟结局的影响因素:Systematic Review
Warren K Bickel,Devin C Tomlinson,William H Craft et al.
Warren K Bickel et al.
This systematic review aims to characterize the utility of machine learning to identify the predictors of smoking cessation outcomes and identify the machine learning methods applied in this area. In the current study, multiple searches occ...
Jacqueline F McGinty
Jacqueline F McGinty
Cocaine self-administration disturbs intracellular signaling in multiple reward circuitry neurons that underlie relapse to drug seeking. Cocaine-induced deficits in prelimbic (PL) prefrontal cortex change during abstinence, resulting in dif...