Jacqueline F McGinty
Jacqueline F McGinty
Cocaine self-administration disturbs intracellular signaling in multiple reward circuitry neurons that underlie relapse to drug seeking. Cocaine-induced deficits in prelimbic (PL) prefrontal cortex change during abstinence, resulting in dif...
Fang Fang,Allan M Andersen,Robert Philibert et al.
Fang Fang et al.
Cigarette smoking has been associated with epigenetic alterations that may be reversible upon cessation. As the most-studied epigenetic modification, DNA methylation is strongly associated with smoking exposure, providing a potential mechan...
Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress [0.03%]
生命早期应激对鼠类成年后上瘾相关行为结果的性别差异的影响研究
Millie Rincón-Cortés
Millie Rincón-Cortés
In humans, exposure to early life stress (ELS) is an established risk factor for the development of substance use disorders (SUDs) during later life. Similarly, rodents exposed to ELS involving disrupted mother-infant interactions, such as ...
Maciej L Goniewicz
Maciej L Goniewicz
This perspective summarizes available evidence on biomarkers of exposure in electronic nicotine delivery system (ENDS) users to aid the overall assessment of the health consequences of using ENDS. Identification of novel biomarkers of expos...
Scott D Siegel,Hilary A Tindle,Andrew W Bergen et al.
Scott D Siegel et al.
This review summarizes the evidence to date on the development of biomarkers for personalizing the pharmacological treatment of combustible tobacco use. First, the latest evidence on FDA-approved medications is considered, demonstrating tha...
Francesco Versace,Jason D Robinson,Paul M Cinciripini
Francesco Versace
Vulnerability to compulsive drug use stems from dysregulated activity within the neural networks that underlie reward and executive functions. Empirical evidence suggests that a) attributing high motivational salience to drug-related stimul...
High-CBD Cannabis Vapor Attenuates Opioid Reward and Partially Modulates Nociception in Female Rats [0.03%]
高CBD大麻蒸气可降低雌性大鼠的阿片类药物奖赏并部分调节其痛觉感知
Maria T Rivera-Garcia,Rizelle Mae Rose,Adrianne R Wilson-Poe
Maria T Rivera-Garcia
Chronic pain patients report analgesic effects when using cannabidiol (CBD), a phytocannabinoid found in whole-plant cannabis extract (WPE). Several studies suggest that cannabis-derived products may serve as an analgesic adjunct or alterna...
HIV gp120 impairs nucleus accumbens neuroimmune function and dopamine D3 receptor-mediated inhibition of cocaine seeking in male rats [0.03%]
HIV gp120损害雄性大鼠伏核神经免疫功能及多巴胺D3受体介导的可卡因求取行为抑制作用
Mark D Namba,Megan N Phillips,Peng-Jen Chen et al.
Mark D Namba et al.
Cocaine Use Disorders (CUDs) are associated with an increased risk of human immunodeficiency virus (HIV) infection. Cocaine and the HIV envelope protein gp120 each induce distinct deficits to mesocorticolimbic circuit function and motivated...
Effects of buprenorphine, methadone, and cariprazine on economic choice between remifentanil and food in squirrel monkeys [0.03%]
布替佐辛、美沙酮和卡利拉嗪对松鼠猴瑞米芬太尼与食物之间的经济选择的影响
Alishan S Amirali,Jacquelin C Hecker,Hector M Figueroa et al.
Alishan S Amirali et al.
We recently reported an economic choice task in which squirrel monkeys chose between differing amounts of remifentanil, a fast-acting opioid, or a food reward to develop a preclinical screen for evaluating potential pharmacotherapies for op...
Kevin M Walton,Evan S Herrmann
Kevin M Walton
Adherence is a critical mediator of treatment outcome across health conditions and low rates of adherence undermine success in smoking cessation treatment. This narrative review provides an overview of different techniques that can be used ...