Electronic Vaporization of Nicotine Salt or Freebase produces differential effects on metabolism, neuronal activity and behavior in male and female C57BL/6J mice [0.03%]
尼古丁盐或基础电子蒸发对雄性和雌性C57BL/6J小鼠的代谢，神经元活性和行为产生不同的影响
Maria Echeveste Sanchez,ManHua Zhu,Sarah Magee et al.
Maria Echeveste Sanchez et al.
The use of Electronic Nicotine Delivery Systems (ENDS) is increasing in prevalence and popularity. ENDS are a rapidly evolving technology as devices and e-liquid formulations adapt to policy restrictions and market demand To identify the im...
Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards [0.03%]
与摄食有关的肽对中缝多巴胺系统的的作用在自然奖赏和药物奖赏的调节中的作用
Anna I Dunigan,Aaron G Roseberry
Anna I Dunigan
The mesolimbic dopamine system is the primary neural circuit mediating motivation, reinforcement, and reward-related behavior. The activity of this system and multiple behaviors controlled by it are affected by changes in feeding and body w...
Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking [0.03%]
岛叶和前扣带回灰质体积及其在吸烟行为中的作用机制研究
Yu Chen,Shefali Chaudhary,Wuyi Wang et al.
Yu Chen et al.
The salience network, including the insula and anterior cingulate cortex (ACC), has been implicated in nicotine addiction. Structural imaging studies have reported diminished insula and ACC gray matter volumes (GMVs) in smokers as compared ...
Predictors of smoking cessation outcomes identified by machine learning: A systematic review [0.03%]
机器学习识别的吸烟结局的影响因素:Systematic Review
Warren K Bickel,Devin C Tomlinson,William H Craft et al.
Warren K Bickel et al.
This systematic review aims to characterize the utility of machine learning to identify the predictors of smoking cessation outcomes and identify the machine learning methods applied in this area. In the current study, multiple searches occ...
Jacqueline F McGinty
Jacqueline F McGinty
Cocaine self-administration disturbs intracellular signaling in multiple reward circuitry neurons that underlie relapse to drug seeking. Cocaine-induced deficits in prelimbic (PL) prefrontal cortex change during abstinence, resulting in dif...
Fang Fang,Allan M Andersen,Robert Philibert et al.
Fang Fang et al.
Cigarette smoking has been associated with epigenetic alterations that may be reversible upon cessation. As the most-studied epigenetic modification, DNA methylation is strongly associated with smoking exposure, providing a potential mechan...
Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress [0.03%]
生命早期应激对鼠类成年后上瘾相关行为结果的性别差异的影响研究
Millie Rincón-Cortés
Millie Rincón-Cortés
In humans, exposure to early life stress (ELS) is an established risk factor for the development of substance use disorders (SUDs) during later life. Similarly, rodents exposed to ELS involving disrupted mother-infant interactions, such as ...
Maciej L Goniewicz
Maciej L Goniewicz
This perspective summarizes available evidence on biomarkers of exposure in electronic nicotine delivery system (ENDS) users to aid the overall assessment of the health consequences of using ENDS. Identification of novel biomarkers of expos...
Scott D Siegel,Hilary A Tindle,Andrew W Bergen et al.
Scott D Siegel et al.
This review summarizes the evidence to date on the development of biomarkers for personalizing the pharmacological treatment of combustible tobacco use. First, the latest evidence on FDA-approved medications is considered, demonstrating tha...
Francesco Versace,Jason D Robinson,Paul M Cinciripini
Francesco Versace
Vulnerability to compulsive drug use stems from dysregulated activity within the neural networks that underlie reward and executive functions. Empirical evidence suggests that a) attributing high motivational salience to drug-related stimul...