Influence of sex, anxiety, and risk-taking behavior on opioid and alcohol polysubstance consumption patterns [0.03%]
性别、焦虑和冒险行为对阿片类药物和酒精多物质消费模式的影响
Makenzie Patarino,Ziheng Christina Wang,Andrew Byungwook Kim et al.
Makenzie Patarino et al.
Polysubstance use is prevalent in the population but remains understudied in preclinical models. Alcohol and opioid polysubstance use is associated with negative outcomes, worse treatment prognosis, and higher overdose risk; but underlying ...
Adolescent social isolation promotes oxycodone consumption and augments mu opioid receptor responsiveness in the ventral pallidum [0.03%]
青春期的社会孤立可促进羟考酮的消耗并增强脑伏核中μ型阿片受体的反应性
Gavin J Vaughan,Hetvi Trivedi,Skylee M Eiffert et al.
Gavin J Vaughan et al.
Exposure to adversity during adolescence augments vulnerability to opioid use disorders in adulthood, yet the neurobiological mechanisms underlying this risk remain incompletely understood. The ventral pallidum (VP) is a region highly impli...
Corticotrophin-releasing hormone binding protein in the basolateral amygdala: divergent roles in cocaine and opioid addiction like behaviors [0.03%]
下丘脑-垂体-肾上腺轴应激相关分子CRH结合蛋白在基底外侧杏仁核中的成瘾作用研究：以可卡因和鸦片类毒品为例
Courtney P Wood,Arnav Gurha,Caitlin Crook et al.
Courtney P Wood et al.
Cocaine and oxycodone use disorders represent urgent public health burdens, with limited treatment options for opioid dependence and no approved pharmacotherapies for cocaine-related disorders, highlighting the critical need to uncover nove...
Corticostriatal cocaine-seeking ensembles are defined by differing gene expression from sucrose-seeking ensembles using a within-subject dual self-administration and seeking mouse model [0.03%]
利用双自我管理与寻求小鼠模型界定皮层纹状体可卡因寻求联盟，而不是糖寻求联盟，并通过不同的基因表达加以区分
Carl G Litif,Levi T Flom,Kathryn L Sandum et al.
Carl G Litif et al.
Recurrent cocaine seeking is a hallmark of cocaine use disorder. To develop therapeutic targets, it is critical to understand the neurobiological changes specific to cocaine-seeking in context with the seeking of non-drug rewards, e.g., suc...
Effects of prenatal methadone and buprenorphine exposure on motivated responding for sucrose and gene expression in adult male and female rats [0.03%]
产前接触美沙酮和丁丙诺啡对成年雄性和雌性大鼠蔗糖趋避反应及基因表达的影响
Kelsea R Gildawie,Kerri E Budge,Fair M Vassoler et al.
Kelsea R Gildawie et al.
The opioid crisis has resulted in escalating rates of opioid use disorder in women of reproductive age and increased prevalence of fetal drug exposure. While medication for opioid use disorder (MOUD) - e.g., buprenorphine or methadone - imp...
The central amygdala corticotropin releasing factor system regulates anxiety-like behavior in an age- and sex- dependent manner in rats [0.03%]
下丘脑视前区催乳素释放肽系统以年龄和性别依赖方式调节大鼠类似焦虑的行为
Kelcie C Schatz,Margaret Agajanov,Elena I Varlinskaya et al.
Kelcie C Schatz et al.
The corticotropin releasing factor (CRF) system is a key regulator of anxiety-like behavior and a major contributor to addiction. The canonical anxiogenic role of CRF has been largely based on CRF manipulations in adult male rodents, partic...
Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose [0.03%]
阿片类药物使用障碍中的海马体积和脑tau病理与非致死性阿片类药物中毒的关系
Delaney McKinstry,Zhenhao Shi,Astrid P Ramos-Rolón et al.
Delaney McKinstry et al.
Opioid use disorder (OUD) is associated with high rates of overdose (OD)-related morbidity and mortality. OD can cause hypoxic-ischemic injury to oxygen-sensitive brain regions such as the hippocampus. Post-mortem studies show Alzheimer's d...
Dysregulation of inhibitory control in young adult binge drinkers: Neuroimaging evidence of gender differences associated with misusing alcohol to cope with negative affect [0.03%]
青年期酗酒者抑制控制失调：利用神经影像学证据揭示情绪应对型酒精滥用的性别差异
Austin B Alderson Myers,David R White,Ksenija Marinkovic
Austin B Alderson Myers
Impaired inhibitory control contributes to compulsive drinking and increased risk of alcohol misuse. While the neural underpinnings of inhibitory control have been well documented, imaging evidence in binge drinkers (BDs) is scarce. Notably...
Multiple memory object-drug association task (MODAT) for the study of polydrug associations [0.03%]
用于研究多药关联的多个记忆对象-药物关联任务(MODAT)
Madalyn Hafenbreidel,Thomas Vaissiere,Erica J Young et al.
Madalyn Hafenbreidel et al.
Polysubstance use is common among individuals with substance use disorder (SUD). However, the underlying neurobiology of the complex interactions between different drug classes is understudied. Further, drug associations can serve as relaps...
Concurrent consumption of ethanol and corticosterone during adolescence alters neuroimmune sensitivity in Sprague Dawley rats [0.03%]
青春期同时摄入乙醇和皮质酮会改变Sprague-Dawley大鼠的神经免疫敏感性
Ashley Lutzke,Ariana L Velazquez,Sarah Trapp et al.
Ashley Lutzke et al.
Chronic stress and alcohol consumption influence various features of neuroimmune reactivity, including neurobehavioral outcomes, induction of neuroimmune genes, blood-brain barrier (BBB) permeability, and core body temperature regulation. T...