Faecalibacterium prausnitzii A2-165 metabolizes host- and media-derived chemicals and induces transcriptional changes in colonic epithelium in GuMI human gut microphysiological system [0.03%]
粪便细菌富氏菌A2-165降解宿主和培养基来源的化合物并在人体肠道微流控芯片中诱导结肠上皮转录组变化
Yu-Ja Huang,Caroline A Lewis,Charles Wright et al.
Yu-Ja Huang et al.
Aim: Recently, a GuMI gut microphysiological system has been established to coculture oxygen-intolerant Faecalibacterium prausnitzii (F. prausnitzii) A2-165 with organoids-derived primary human colonic epithelium. This study aims to test if...
A pilot case-control study on the fecal microbiota of pediatric functional abdominal pain-not otherwise specified and the role of early life stress [0.03%]
儿童功能性腹痛不适和早年压力经历相关的粪便菌群的病例对照研究
Nize Otaru,Benoît Pugin,Serafina Plüss et al.
Nize Otaru et al.
Background: Gut microbial features and the role of early life stress in pediatric functional abdominal pain-not otherwise specified (FAP-NOS) have never been investigated before. Here, we hypothesize that early life stress is more prevalent...
Effect of protein modification in synbiotic infant formula on probiotic metabolic activity and bacterial composition in an infant gut-model [0.03%]
一种新型合生元婴儿配方奶粉中的蛋白质修饰对婴儿肠道模型中益生菌代谢活性及菌群组成的影响
Eline Suzanne Klaassens,Mirna Lilian Baak,Nienke Jacobine Mekkes et al.
Eline Suzanne Klaassens et al.
Aim: Microbial colonization of the neonatal gut is pivotal in priming the infant's immune system. Human milk (HM) is the best nutrition for infants and supports the development of the microbiota due to prebiotic compounds and probiotic micr...
Supplementation with a cranberry extract favors the establishment of butyrogenic guilds in the human fermentation SHIME system [0.03%]
越橘提取物补充有利于发酵型SHIME系统中丁酸产生菌群的建立
Valentina Cattero,Charlène Roussel,Jacob Lessard-Lord et al.
Valentina Cattero et al.
Background: Proanthocyanidins (PAC) and oligosaccharides from cranberry exhibit multiple bioactive health properties and persist intact in the colon post-ingestion. They display a complex bidirectional interaction with the microbiome, which...
Analysis of the fermentation kinetics and gut microbiota modulatory effect of dried chicory root reveals the impact of the plant-cell matrix rationalizing its conversion in the distal colon [0.03%]
发酵动力学及菊苣根对肠道微生物调节作用的分析表明，植物细胞基质对其在远端结肠中的转化有影响
Marie-Luise Puhlmann,Ember van de Rakt,Evangelia N Kerezoudi et al.
Marie-Luise Puhlmann et al.
Aim: The cell matrix of plant foods has received little attention in prebiotic fiber research. We aimed to understand the impact of the plant cell matrix in dried chicory root on its breakdown in the human gut to explain its reported benefi...
Pangenomic analysis identifies correlations between Akkermansia species and subspecies and human health outcomes [0.03%]
泛基因组分析发现了Akkermansia物种和亚种与人类健康结果之间的关联
Katherine D Mueller,M Emilia Panzetta,Lauren Davey et al.
Katherine D Mueller et al.
Aim: Akkermansia are common members of the human gastrointestinal microbiota. The prevalence of these mucophilic bacteria, especially Akkermansia muciniphila (A. muciniphila), correlates with immunological and metabolic health. The genus Ak...
Putative pseudolysogeny-dependent phage gene implicated in the superinfection resistance of Cutibacterium acnes [0.03%]
参与痤疮丙酸杆菌超感染抵抗的假潜伏依赖性噬菌体基因的鉴定
Stephanie Wottrich,Stacee Mendonca,Cameron Safarpour et al.
Stephanie Wottrich et al.
Objectives: Cutibacterium acnes, formerly Propionibacterium acnes, is a bacterial species characterized by tenacious acne-contributing pathogenic strains. Therefore, bacteriophage therapy has become an attractive treatment route to circumve...
Assessing fecal metaproteomics workflow and small protein recovery using DDA and DIA PASEF mass spectrometry [0.03%]
利用DDA和DIA PASEF质谱评估粪便元蛋白质组工作流程及小蛋白回收率
Angela Wang,Emily E F Fekete,Marybeth Creskey et al.
Angela Wang et al.
Aim: This study aims to evaluate the impact of experimental workflow on fecal metaproteomic observations, including the recovery of small and antimicrobial proteins often overlooked in metaproteomic studies. The overarching goal is to provi...
Probiotics, prebiotics, synbiotics and other microbiome-based innovative therapeutics to mitigate obesity and enhance longevity via the gut-brain axis [0.03%]
通过肠-脑轴减轻肥胖和增强长寿的益生元、益生菌、合生元及其他基于微生物组的创新疗法
Jacqueline L Boyajian,Paromita Islam,Ahmed Abosalha et al.
Jacqueline L Boyajian et al.
The global prevalence of obesity currently exceeds 1 billion people and is accompanied by an increase in the aging population. Obesity and aging share many hallmarks and are leading risk factors for cardiometabolic disease and premature dea...
An exploratory in silico analysis of bacteriocin gene clusters in the urobiome [0.03%]
尿生殖道微生物组中细菌素基因簇的探究式计算分析
Jennifer Jones,Craig P Murphy,Roy D Sleator et al.
Jennifer Jones et al.
Background: The role of the urobiome in health and disease remains an understudied area compared to the rest of the human microbiome. Enhanced culturing techniques and next-generation sequencing technologies have identified the urobiome as ...