Therapeutic potential of Lachnospiraceae strains in irritable bowel syndrome via differential gut-brain pathways [0.03%]
通过不同的肠-脑途径在肠易激综合征中利用Lachnospiraceae菌株的治疗潜力
Wanyu Yang,Shuigen Bian,Huizi Tan
Wanyu Yang
Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder that significantly impairs quality of life, yet effective treatments remain limited. While prior work from our laboratory linked the Lachnospiraceae family to IBS sev...
Immunoglobulin Y protects intestinal epithelium and modulates gut microbiota [0.03%]
免疫球蛋白Y保护肠上皮并调节肠道微生物群
Shahna Fathima,Tina Sarkar,Navneet Sharma et al.
Shahna Fathima et al.
Aim: This study investigated the effects of Muno-IgY®, a multi-pathogen-specific immunoglobulin Y (IgY), on microbial growth, adhesion, fermentation activity, and immune signaling using a multi-tiered in vitro approach. Methods: IgY activi...
Intestinal mucus acts as a nutrient source and signal for Klebsiella pneumoniae [0.03%]
肠道黏液作为肺炎克雷伯氏菌的营养来源和信号分子
Taylor D Ticer,Pramita Suresh,Subhomitra Ghoshal et al.
Taylor D Ticer et al.
Background: Klebsiella pneumoniae can colonize the gastrointestinal tract, yet its interactions with intestinal mucus remain poorly defined. In this study, we examined the capacity of Klebsiella pneumoniae (K. pneumoniae) to adhere and use ...
Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults [0.03%]
菊糖半乳聚糖-I调节健康成年人肠道微生物群和免疫反应
Evangelia N Kerezoudi,Sue McKay,Seta Kurt et al.
Evangelia N Kerezoudi et al.
Background: Pectic rhamnogalacturonan-I (RG-I) is a dietary fiber that modulates the gut-immune axis. This study evaluates a novel variant of RG-I from chicory root (chRG-I). Methods: In a randomized, double-blind, placebo-controlled trial,...
Bacterial clusters are associated with the risk of severe disease progression in inflammatory bowel disease irrespective of conventional disease categories [0.03%]
菌群聚集与炎症性肠病严重疾病进展风险相关，不受传统疾病分类的影响
Simen Hyll Hansen,Niharika Bhattacharjee,Chang Hu et al.
Simen Hyll Hansen et al.
Background: Inflammatory bowel diseases (IBDs) are complex conditions marked by chronic inflammation in the gastrointestinal tract. Traditional classification separates IBD into Crohn's disease and ulcerative colitis, but this division may ...
Development of a multi-targeted metabolomics platform for semi-quantification of faecal metabolites: a proof-of-concept analysis in human faeces [0.03%]
一种多目标代谢组学平台的开发用于粪便代谢物的半定量分析：人类粪便中的概念验证分析
Kayo Ikuta,Akihiro Kunisawa,Itaru Dekio et al.
Kayo Ikuta et al.
Objectives: Targeted metabolomic analysis of faecal samples has been limited by narrow chemical coverage. Here, we established a multiplexed, triple quadrupole mass spectrometry (TQMS)-based targeted metabolomics workflow. This workflow all...
Unveiling the genetic landscape and motility-associated functions of Type IV pili in the Bifidobacterium genus [0.03%]
双歧杆菌属中第四型菌毛的基因景观和与运动相关功能的揭示
Gabriele Andrea Lugli,Emanuele Selleri,Chiara Tarracchini et al.
Gabriele Andrea Lugli et al.
Background: Bifidobacteria are recognized as one of the most influential bacterial groups inhabiting the human gut, capable of modulating the host's health. To understand how these bacteria interact with their hosts, it is essential to inve...
MUC2 shifts the metabolic profiles of commensal bacteria in defined microbial communities [0.03%]
MUC2改变定义的微生物群落中共生细菌的代谢谱
Erin Chard,Adelaide E Horvath,Makenna Grozis et al.
Erin Chard et al.
Background: The intestinal mucus layer is comprised of heavily glycosylated mucins, including mucin 2 (MUC2), that serve as a nutrient source for certain bacterial members of the gut microbiota. Only a subset of gut commensals encode the gl...
Quantification of the absolute abundance of the jejunal mucosa-associated microbiota of pigs using spike-in control [0.03%]
采用内标控制法对猪空肠黏膜相关微生物菌群绝对丰度的定量研究
Jung Yeol Sung,Hyunjun Choi,Alexa R Gormley et al.
Jung Yeol Sung et al.
The objective was to quantify the absolute abundance of the jejunal mucosa-associated microbiota in pigs and develop a standardized spike-in control protocol. The spike-in control, containing bacteria that are Gram-negative (Imtechella halo...