A responder-informed gut microbial consortium enhances anti-PD-1 efficacy in a mouse cancer model [0.03%]
一种受应答者信息影响的肠道微生物群联盟可增强小鼠癌症模型中抗PD-1疗效
Uk Jin Jeong,Mohammed Ali,Yun Jee Park et al.
Uk Jin Jeong et al.
Aim: Immune checkpoint inhibitors (ICIs), particularly anti-programmed cell death protein 1 (PD-1) therapy, have improved cancer treatment outcomes, yet durable benefit is achieved in only a subset of patients. Growing evidence implicates t...
An overview of the role of the gut microbiota in rheumatoid arthritis [0.03%]
肠道菌群在类风湿性关节炎发病机制中的作用概述
Anastasia V Poznyak,Aleksey A Vatlin,Vsevolod V Pavshintsev et al.
Anastasia V Poznyak et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease preceded by a prolonged preclinical phase marked by the emergence of autoantibodies and mucosal immune dysregulation. Evidence from human studies and animal models consistently demon...
Taxonomic and mechanistic insights into gut microbiota bioaccumulation of entacapone using bioorthogonal drug labelling [0.03%]
用于肠道微生物药物生物累积的生物正交药物标记的分类和机理见解
Linda M Guantai,Clementine E Bavinton,Juwairiyah B Shazzad et al.
Linda M Guantai et al.
Aim: The gut microbiota plays a key role in shaping individual responses to drugs, but current tools have limited potential to probe drug-microbe interactions within the complex, individualised gut environment. This study employed bioorthog...
Approaches to dissect the vitamin biosynthetic network of the gut microbiota [0.03%]
解构肠道微生物组维生素生物合成网络的方法学研究进展
Chiara Tarracchini,Francesca Bottacini,Leonardo Mancabelli et al.
Chiara Tarracchini et al.
B-group vitamins and vitamin K are essential micronutrients required for numerous cellular processes in both microbial and human physiology. While traditionally considered to originate predominantly from dietary sources, the biosynthetic ca...
Immunomodulatory properties of dietary polyphenols: a role for combating infections at mucosal surfaces? [0.03%]
饮食多酚的免疫调节特性：是否有助于对抗黏膜表面的感染？
Mona Sharma,Yves Desjardins,Andrew R Williams
Mona Sharma
Polyphenols are food components with antioxidant and anti-inflammatory properties, and their health benefits are increasingly recognized in the context of noncommunicable diseases such as type 2 diabetes. However, their role in regulating i...
Leonardo Mancabelli,Christian Milani,Giulia Longhi et al.
Leonardo Mancabelli et al.
Aim: Plant-derived proteins have emerged as promising alternatives to animal-based proteins, offering not only environmental and nutritional benefits to the human host but also potential effects on the gut microbiota. Yellow pea (Pisum sati...
Mechanistic roles and therapeutic potential of bacteriophages in inflammatory gastrointestinal diseases [0.03%]
噬菌体在炎症性胃肠疾病中的作用及治疗潜力
Baiyun Ding,Mingze Fan,Yong-Peng Shi et al.
Baiyun Ding et al.
The gut virome, particularly its viral and phage components, is increasingly recognized as a key modulator of intestinal microbial dynamics in gastrointestinal inflammatory diseases. Beyond well-characterized bacterial dysbiosis, growing ev...
Gut bioengineered models to study host-microbiota-probiotics interactions [0.03%]
肠道生物工程模型用于研究宿主-微生物群-益生菌相互作用
Elise Delannoy,Alexandre Grassart,Catherine Daniel
Elise Delannoy
The gastrointestinal tract is the major ecological niche in which gut microbes interact with epithelial and immune cells to maintain homeostasis in mammals. Moreover, probiotics modulate the gut microbiota and exert various health benefits ...
Benchmarking and optimizing microbiome-based bioinformatics workflow for non-invasive detection of intestinal tumors [0.03%]
基于微生物组的非侵入性检测肠道肿瘤的生物信息学工作流的基准测试与优化
Yangyang Sun,Yongxiang Huang,Ruichen Li et al.
Yangyang Sun et al.
Background: The human gut microbiome is closely linked to disease states, offering substantial potential for novel disease detection tools based on machine learning (ML). However, variations in feature types, data preprocessing strategies, ...
Effect of a polyphenol-rich dietary pattern on subjects aged ≥ 60 years with higher levels of inflammatory markers: insights into microbiome and metabolome [0.03%]
富含多酚的饮食模式对老年人血炎症标记物水平较高的个体的影响：来自微生物组和代谢组的见解
Giorgio Gargari,Tomas Meroño,Gregorio Peron et al.
Giorgio Gargari et al.
Background: Aging may be associated with low-grade chronic inflammation ("inflammaging") and gut microbiome alterations. Dietary polyphenols have been proposed as modulators of these processes. This study aimed to explore the effects of a p...