Establishing genetic manipulation for novel strains of human gut bacteria [0.03%]
建立新型人类肠道细菌菌株的基因工程技术
Paul O Sheridan,Ma&#x;en Al Odat,Karen P Scott
Paul O Sheridan
Recent years have seen the development of high-accuracy and high-throughput genetic manipulation techniques, which have greatly improved our understanding of genetically tractable microbes. However, challenges remain in establishing genetic...
Marco Ventura,Douwe van Sinderen,Francesca Turroni et al.
Marco Ventura et al.
Comparison of k-mer-based de novo comparative metagenomic tools and approaches [0.03%]
基于k-mer的从头比较元基因组工具和方法的比较
Alise Jany Ponsero,Matthew Miller,Bonnie Louise Hurwitz
Alise Jany Ponsero
Aim: Comparative metagenomic analysis requires measuring a pairwise similarity between metagenomes in the dataset. Reference-based methods that compute a beta-diversity distance between two metagenomes are highly dependent on the quality an...
Connect the dots: sketching out microbiome interactions through networking approaches [0.03%]
连接点：通过网络方法勾勒微生物组相互作用
Marco Fabbrini,Daniel Scicchitano,Marco Candela et al.
Marco Fabbrini et al.
Microbiome networking analysis has emerged as a powerful tool for studying the complex interactions among microorganisms in various ecological niches, including the human body and several environments. This analysis has been used extensivel...
MEGAnnotator2: a pipeline for the assembly and annotation of microbial genomes [0.03%]
MEGAnnotator2：微生物基因组组装和注释的流水线方法
Gabriele Andrea Lugli,Federico Fontana,Chiara Tarracchini et al.
Gabriele Andrea Lugli et al.
The reconstruction of microbial genome sequences by bioinformatic pipelines and the consequent functional annotation of their genes' repertoire are fundamental activities aiming at unveiling their biological mechanisms, such as metabolism, ...
The importance of the timing of microbial signals for perinatal immune system development [0.03%]
微生物信号发生时间对于围产期免疫系统发育的重要性
Dale Archer,Maria Elisa Perez-Muñoz,Stephanie Tollenaar et al.
Dale Archer et al.
Background: Development and maturation of the immune system begin in utero and continue throughout the neonatal period. Both the maternal and neonatal gut microbiome influence immune development, but the relative importance of the prenatal ...
Exploring Bifidobacterium species community and functional variations with human gut microbiome structure and health beyond infancy [0.03%]
双歧杆菌物种的群落和功能变化与人类肠道微生物组结构及1岁以后的健康状况之间的关系探究
Ruben Ladeira,Julien Tap,Muriel Derrien
Ruben Ladeira
Aim: The human gut Bifidobacterium community has been studied in detail in infants and following dietary interventions in adults. However, the variability of the distribution of Bifidobacterium species and intra-species functions have been ...
Profiling of the intestinal community of Clostridia: taxonomy and evolutionary analysis [0.03%]
肠促菌生长的分类和进化分析
Francesco Candeliere,Eliana Musmeci,Alberto Amaretti et al.
Francesco Candeliere et al.
Aim: Clostridia are relevant commensals of the human gut due to their major presence and correlations to the host. In this study, we investigated intestinal Clostridia of 51 healthy subjects and reconstructed their taxonomy and phylogeny. T...
The role of human milk fats in shaping neonatal development and the early life gut microbiota [0.03%]
母乳脂肪在塑造新生儿发育和生命早期肠道微生物群方面的作用
David Seki,Theresa Errerd,Lindsay J Hall
David Seki
Human breast milk (HBM) is the main source of nutrition for neonates across the critical early-life developmental period. The highest demand for energy is due to rapid neurophysiological expansion post-delivery, which is largely met by huma...
A tool to assess the mock community samples in 16S rRNA gene-based microbiota profiling studies [0.03%]
一种基于16S rDNA的微生物组研究中评估模拟菌群样本的方法
Sudarshan A Shetty,Jolanda Kool,Susana Fuentes
Sudarshan A Shetty
Inclusion and investigation of technical controls in microbiome sequencing studies is important for understanding technical biases and errors. Here, we present chkMocks, a general R-based tool that allows researchers to compare the composit...