Progress in phase III clinical trials of molecular targeted therapy and immunotherapy for glioblastoma [0.03%]
胶质母细胞瘤分子靶向治疗和免疫治疗Ⅲ期临床研究进展
Yuekun Wang,Shenglan Li,Yichen Peng et al.
Yuekun Wang et al.
Glioblastoma (GBM) is the most common primary central nervous system tumor, whose prognosis remains poor under the sequential standard of care, such as neurosurgery followed by concurrent temozolomide radiochemotherapy and adjuvant temozolo...
Oleg Gaidai,Yihan Xing,Rajiv Balakrishna et al.
Oleg Gaidai et al.
Background: To estimate cardiovascular and cancer death rates by regions and time periods. Design: Novel statistical methods were used ...
Advances and prospects of drug clinical research in colorectal cancer in 2022 [0.03%]
2022年结直肠癌药物临床研究进展与展望
Dan Su,Chao Liu,Jie Cui et al.
Dan Su et al.
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer death worldwide. Clinical research results have provided more treatment opportunities for CRC patients, showing that an optimal combination of ex...
Jing Tian,Jiayu Wang,Sidan Li
Jing Tian
Tumor is one of the leading causes of death in children (0 to 14-year-old) and adolescents (15 to 19-year-old) worldwide. Unlike adult tumors, childhood and adolescent tumors are unique in their type, molecular characteristics, and pathogen...
Large cell neuroendocrine carcinoma transformation: A novel acquired drug resistance mechanism in colorectal adenocarcinoma [0.03%]
大细胞神经内分泌癌转化：结肠腺癌中一种新颖的获得性耐药机制
Feng Du,Ying Han,Xiao Hu et al.
Feng Du et al.
Acquired resistance is a major problem limiting the clinical efficacy of treatments for metastatic colorectal cancer (mCRC). Histological transformation is an important mechanism underlying the acquired resistance of non-small cell lung can...
Case Reports
Cancer innovation. 2023 Mar 20;2(2):159-164. DOI:10.1002/cai2.57 2023
An integrated analysis of C5AR2 related to malignant properties and immune infiltration of gliomas [0.03%]
C5AR2在胶质瘤恶性表型及相关免疫浸润中的整合分析
Chengying Huang,Ouwen Qiu,Chaofu Mao et al.
Chengying Huang et al.
Background: C5AR2 is recognized as a proinflammatory molecule and activates the inflammatory response in multiple disorders. However, little has been reported on C5AR2 in glioma. This study sought to explore its expressio...
Jingyi Cui,Meng Chen,Lanxin Zhang et al.
Jingyi Cui et al.
Circular RNAs (circRNAs) are a class of single-stranded closed RNAs that are produced by the back splicing of precursor mRNAs. The formation of circRNAs mainly involves intron-pairing-driven circularization, RNA-binding protein (RBP)-driven...
Research progress in the establishment of pancreatic cancer models and preclinical applications [0.03%]
胰腺癌模型的建立及临床前应用研究进展
Weizheng Wu,Kunming Wen,Yuxin Zhong
Weizheng Wu
Pancreatic cancer (PC) is a highly malignant tumor in the digestive system. The transformation of tissue from normal to pancreatic intraepithelial neoplasm is driven by certain oncogenes, among which the mutation rate of the KRAS gene is as...
Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer [0.03%]
乳腺癌中LIM家盒转录因子的预后指标、诊断标志物和潜在治疗靶点的识别
Pingping Gao,Na Sun,Tingting Zhao et al.
Pingping Gao et al.
Background: Breast cancer (BRCA) is the most common malignant tumor among women worldwide. Despite advances in treatment, many patients still die from a lack of effective diagnostic and prognostic markers and powerful the...