AI and Big Data in Oncology: A Physician-Centered Perspective on Emerging Clinical and Research Applications [0.03%]
肿瘤学中的人工智能和大数据：新兴临床和研究应用的医师视角
Binliang Liu,Qingyao Shang,Jun Li et al.
Binliang Liu et al.
The convergence of artificial intelligence (AI) and big data is reshaping contemporary oncology by enabling the integration of multimodal information across imaging, pathology, genomics, and clinical records. From a physician-centered persp...
Global, Population and Genetic Evidence on the Relationships Between Immune-Mediated Inflammatory Disease and Cancer Risk [0.03%]
基于全球、人口和遗传证据探讨免疫介导的炎症性疾病与癌症风险之间的关系
Xuesi Dong,Jiaxin Xie,Zilin Luo et al.
Xuesi Dong et al.
Background: Immune-mediated inflammatory disease (IMID) and cancer share underlying mechanisms. We aimed to comprehensively evaluate the associations between IMIDs and cancers from global, population and genetic perspecti...
Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer [0.03%]
放射核素治疗乳腺癌的潜在靶点和生物标志物
Yujing Tan,Cheng Zeng,Jiani Wang et al.
Yujing Tan et al.
In recent years, multidisciplinary treatment strategies have profoundly improved drug responses and survival outcomes of breast cancer (BC) patients. However, there is an urgent need for novel therapies for BC patients who are heavily treat...
Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence [0.03%]
他汀类药物在乳腺癌治疗中的机制见解和新兴证据
Rohina Alim,H M Kasuni Akalanka
Rohina Alim
Breast cancer (BC) remains the most frequently diagnosed malignancy worldwide, with an estimated 2.3 million new cases and approximately 685,000 deaths reported in 2020. Forecasts suggest a substantial rise in global incidence, with new ann...
Artificial Intelligence-Enabled Electrocardiogram for the Detection and Management of Cancer Therapy-Related Cardiotoxicity [0.03%]
人工智能心电图在癌症治疗相关心脏毒性检测和管理中的应用
Wenhua Song,Runze Gao,Tong Liu
Wenhua Song
Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies [0.03%]
筛选Eclipta prostrata的活性植物化学成分并揭示其分子作用机制以对抗人类恶性肿瘤
Md Sakhawat Hossain,Sanjida Khatun,Md Mojnu Mia et al.
Md Sakhawat Hossain et al.
Current drugs against multiple human malignancies are limited, and developing new treatment strategies is improbable within a short time. So, considering the current situation, phytochemicals could be a viable option for developing chemothe...
Wei Dong,Shengbin Pei,Dacheng Zhu et al.
Wei Dong et al.
DNA methylation is a crucial epigenetic regulatory mechanism that can modify chromatin structure, DNA conformation, DNA stability, and the interactions between DNA and proteins, thereby controlling gene expression. It has been shown to play...
Bidirectional Causal Effect Between Gut Microbiota and Glioma Risk: A Systematic Review-Based Mendelian Randomization and Immune-Mediated Effect Analysis [0.03%]
基于系统综述的孟德尔随机化和免疫介导效应分析下的肠道微生物与胶质瘤风险间的双向因果关系
Jiachen Wang,Yilin Zhang,Zhuang Kang et al.
Jiachen Wang et al.
Background: Glioma is the most common malignant tumor in the central nervous system, with unclear pathogenesis and poor treatment outcomes. Recent research reveals that the brain-gut axis-involving gut microbiota and immu...
mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics [0.03%]
基于 mRNA 的癌症疫苗：从大流行病范式到个性化肿瘤治疗
Bo Yang,Juan Liu,Yang Li et al.
Bo Yang et al.
The groundbreaking success of messenger RNA (mRNA) vaccines during the COVID-19 pandemic has significantly accelerated their application in oncology. This review comprehensively synthesizes the recent advancements in mRNA cancer vaccine dev...
Zhehao Cui,Dandan Wang,Ye Zhang et al.
Zhehao Cui et al.
Tryptophan (Trp) is an essential amino acid that serves as a precursor for the synthesis of several important bioactive compounds. Trp is involved in a variety of pathophysiological processes, including neuronal function, metabolism, inflam...