Neoantigen vaccine and neoantigen-specific cell adoptive transfer therapy in solid tumors: Challenges and future directions [0.03%]
肿瘤新抗原疫苗和新抗原特异性细胞过继转移治疗：挑战与未来方向
Yanwei Shen,Lu Yu,Xiaoli Xu et al.
Yanwei Shen et al.
The phenomenon of tumor hierarchy and genetic instability can be explained by the "two-hits theory" and results in the occurrence of many somatic mutations. The expression of nonsynonymous mutations results in the production of mutant prote...
Pooled analyses of randomized controlled trials on pyrotinib plus capecitabine and a rethink of the first-line options for HER2-positive relapsed or metastatic breast cancer [0.03%]
吡咯替尼联合卡培他滨治疗HER2阳性复发或转移性乳腺癌的随机对照试验汇总分析及对一线用药选择的新思考
Xiuwen Guan,Fei Ma,Binghe Xu
Xiuwen Guan
This pooled analysis explored the possibility and potential of pyrotinib plus capecitabine as a first-line regimen in relapsed or metastatic HER2-positive breast cancer patients who received prior adjuvant or neoadjuvant chemotherapy with t...
Opportunities and challenges of immune checkpoint inhibitors for extensive-stage small-cell lung cancer [0.03%]
免疫检查点抑制剂治疗广泛期小细胞肺癌的机遇与挑战
Jing Zhao,Xiaoli Zhuo,Lei Liu et al.
Jing Zhao et al.
Small-cell lung cancer (SCLC) accounts for 15%-20% of primary lung cancers, and it is characterized by low differentiation, rapid proliferation, and early metastasis. At least two-thirds of SCLC patients present with the extensive stage (ES...
Radiotherapy, photodynamic therapy, and cryoablation-induced abscopal effect: Challenges and future prospects [0.03%]
放射治疗、光动力学治疗和冷冻消融引发的远处效应：挑战与未来展望
Sadik Ali Mohammad,Arshadul Hak,Sunil V Pogu et al.
Sadik Ali Mohammad et al.
Local therapy modalities such as radiation therapy, photodynamic therapy, photothermal therapy, and cryoablation have been used to treat localized tumors for decades. The discovery of the abscopal effect causes a paradigm shift where local ...
Treatment-related adverse events of antibody-drug conjugates in clinical trials: A systematic review and meta-analysis [0.03%]
抗体药物偶联物临床试验中的治疗相关不良事件的系统评价和meta分析
Jinming Li,Guoshuang Shen,Zhen Liu et al.
Jinming Li et al.
Background: The wide use of antibody-drug conjugates (ADCs) is transforming the cancer-treatment landscape. Understanding the treatment-related adverse events (AEs) of ADCs is crucial for their clinical application. We co...
Machine-learning radiomics to predict bone marrow metastasis of neuroblastoma using magnetic resonance imaging [0.03%]
基于磁共振成像的机器学习影像组学预测神经母细胞瘤骨髓转移
Lin Lv,Zhengtao Zhang,Dongbo Zhang et al.
Lin Lv et al.
Background: Neuroblastoma is one common pediatric malignancy notorious for high temporal and spatial heterogeneities. More than half of its patients develop distant metastases involving vascularized organs, especially the...
Mónica Suárez Korsnes,Reinert Korsnes
Mónica Suárez Korsnes
Background: Video recording of cells offers a straightforward way to gain valuable information from their response to treatments. An indispensable step in obtaining such information involves tracking individual cells from...
A case report of multimodal ultrasound imaging in the diagnosis of giant retroperitoneal ganglioneuroma [0.03%]
多模态超声在巨大腹膜后神经节神经瘤诊断中的应用——一例报告
Li Feng,Yong Wang
Li Feng
Retroperitoneal ganglioneuroma is a rare benign tumor that is challenging in terms of clinical diagnosis. Computed tomography and magnetic resonance imaging are usually performed for diagnosis rather than convenient and inexpensive ultrason...
Case Reports
Cancer innovation. 2023 May 10;2(5):433-437. DOI:10.1002/cai2.73 2023
Bo Lan,Qiao Li,Fei Ma et al.
Bo Lan et al.
Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple-negative breast cancer [0.03%]
人果糖激酶代谢物差异的鉴定及与肺癌预后的相关性分析
Yue Song,Guiying Bai,Xiaoqing Li et al.
Yue Song et al.
Background: Metaplastic breast carcinoma (MBC) is a rare breast cancer subtype; most cases are triple-negative breast cancers (TNBCs) and are poorly responsive to conventional systemic therapy. Few potential diagnostic an...