Efficacy and safety of first-line regimens for advanced HER2-positive breast cancer: A Bayesian network meta-analysis [0.03%]
曲妥珠单抗为基础的一线疗法治疗HER2阳性晚期乳腺癌的疗效和安全性：贝叶斯网状Meta分析
Lixi Li,Yun Wu,Bo Lan et al.
Lixi Li et al.
Background: The current standard of care for advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer is pertuzumab plus trastuzumab and docetaxel as first-line therapy. However, with the developmen...
Novel progressive deep learning algorithm for uncovering multiple single nucleotide polymorphism interactions to predict paclitaxel clearance in patients with nonsmall cell lung cancer [0.03%]
一种新的渐进式深度学习算法 用于挖掘多个单核苷酸多态性相互作用 以预测非小细胞肺癌患者紫杉醇清除率
Wei Chen,Haiyan Zhou,Mingyu Zhang et al.
Wei Chen et al.
Background: The rate at which the anticancer drug paclitaxel is cleared from the body markedly impacts its dosage and chemotherapy effectiveness. Importantly, paclitaxel clearance varies among individuals, primarily becau...
Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes [0.03%]
肺肉瘤样癌的整合型基因组和转录组谱特征识别具有不同免疫表型和临床结果的分子亚型
Sahil Seth,Runzhe Chen,Yang Liu et al.
Sahil Seth et al.
Background: Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small cell lung cancer (NSCLC), characterized by the presence of epithelial and sarcoma-like components. The molecular and immune l...
Personalized surgical recommendations and quantitative therapeutic insights for patients with metastatic breast cancer: Insights from deep learning [0.03%]
基于深度学习的转移性乳腺癌患者个性化手术推荐及量化治疗效果研究
Enzhao Zhu,Linmei Zhang,Jiayi Wang et al.
Enzhao Zhu et al.
Background: The role of surgery in metastatic breast cancer (MBC) is currently controversial. Several novel statistical and deep learning (DL) methods promise to infer the suitability of surgery at the individual level. ...
Cardiovascular toxicity with CTLA-4 inhibitors in cancer patients: A meta-analysis [0.03%]
细胞毒性T淋巴细胞相关蛋白4抑制剂治疗癌症患者的心血管毒性的 meta 分析
Huiyi Liu,Lu Fu,Shuyu Jin et al.
Huiyi Liu et al.
Background: With the emergence of cytotoxic T lymphocyte-associated protein-4 (CTLA-4) inhibitors, the outcomes of patients with malignant tumors have improved significantly. However, the incidence of cardiovascular adver...
Histone deacetylase 6 as a novel promising target to treat cardiovascular disease [0.03%]
组蛋白去乙酰酶6作为心血管疾病治疗的新靶点
Ya-Xi Wu,Bing-Qian Li,Xiao-Qian Yu et al.
Ya-Xi Wu et al.
Histone deacetylase 6 (HDAC6) belongs to a class of epigenetic targets that have been found to be a key protein in the association between tumors and cardiovascular disease. Recent studies have focused on the crucial role of HDAC6 in regula...
Prognostic value of cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis: A systematic review and meta-analysis [0.03%]
免疫检查点抑制剂相关心肌炎的心血管磁共振影像的预后价值：系统回顾和meta分析
Wenhua Song,Nan Zhang,Tonglian Lv et al.
Wenhua Song et al.
Background: Immune checkpoint inhibitors (ICI) are increasingly used in the first-line treatment of malignant tumors. There is increasing recognition of their cardiotoxicity and, in particular, their potential to lead to ...
Establishment of a humanized mouse model using steady-state peripheral blood-derived hematopoietic stem and progenitor cells facilitates screening of cancer-targeted T-cell repertoires [0.03%]
基于稳态外周血造血干细胞和祖细胞的人源化小鼠模型的建立，促进了癌症靶向T细胞谱系筛选
Yulin Xu,Wei Shan,Qian Luo et al.
Yulin Xu et al.
Background: Cancer-targeted T-cell receptor T (TCR-T) cells hold promise in treating cancers such as hematological malignancies and breast cancers. However, approaches to obtain cancer-reactive TCR-T cells have been unsuc...
MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer [0.03%]
MAPK4通过抑制ERK途径促进非小细胞肺癌的血管生成
Jing Chen,Jing Yang,Yufang Liu et al.
Jing Chen et al.
Background: Angiogenesis plays an important role in the occurrence and development of non-small cell lung cancer (NSCLC). The atypical mitogen-activated protein kinase 4 (MAPK4) has been shown to be involved in the pathog...
Identification of a disulfidptosis-related prognostic signature for prediction of the effect of treatment in patients with endometrial carcinoma [0.03%]
识别与子宫癌患者治疗反应相关的二硫化物缺乏症相关预后标志物
Lu Peng,Yuan Gao,Zifeng Cao et al.
Lu Peng et al.
Background: Disulfide, an essential compounds family, has diverse biological activity and can affect the dynamic balance between physiological and pathological states. A recently published study found that aberrant accumu...